- Alamby Miller Scrapbook, 1864/18701
- Alexander Lockhart Nelson papers, 1848/19021
- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- American Civil War collection, 1860/18951
- Anderson Family papers, 1755/19581
- Ann Smith Academy Papers, 1807/19101
- Baer Family Papers, 1744/19291
- Brooks Family Papers, 1841/18841
- Campbell Family Papers, 1843/19501
- David Ballenger Correspondence, 1858/18881
- Davidson Family Papers, 1830/19151
- Dillon Family Papers, 1805/19441
- Dunlap Family Papers, 1830/18781
- Edmondson Family Papers, 1861/19041
- Edwin Luther Green Papers, 1865/19271