- Alfred Leyburn Papers, 1823/1899, bulk 1830/18391
- Anderson Family papers, 1755/19581
- Ann Smith Academy Papers, 1807/19101
- Baer Family Papers, 1744/19291
- Brooks Family Papers, 1841/18841
- Campbell Family Papers, 1843/19501
- Davidson Family Papers, 1830/19151
- Dillon Family Papers, 1805/19441
- Dunlap Family Papers, 1830/18781
- Edson J. Harkness Papers, 1827/18651
- Ellinor Porcher Gadsden Papers, 1839/19751
- Francis McFarland Papers, 1815/18711
- Francis P. Gaines Papers, 1803/19791
- Francis Wilkinson Pickens collection, 1826/18651
- Franklin Society records, 1801/18911