- Anderson Family papers, 1755/19581
- Ann Smith Academy Papers, 1807/19101
- Baer Family Papers, 1744/19291
- Dillon Family Papers, 1805/19441
- Duncan Green Campbell Papers, 1789/18251
- Francis McFarland Papers, 1815/18711
- Francis P. Gaines Papers, 1803/19791
- Franklin Society records, 1801/18911
- George A. Baxter Family papers, 1797/19181
- George Washington collection, 1775/19491
- Lee-Jackson Foundation collection, 1775/19131
- Pickens Family Papers, 1812/18691
- Reid Family papers, 1760/18961
- Reverend Samuel Houston correspondence, 1821/18361
- Robert E. Lee Family papers, 1792/1935, bulk 1833/18701