- Mary and Hannah Gibbons Papers, 1743/18901
- Maupin-Washington Papers, 1732/19321
- Michael La Vean French documents collection, 1751/18511
- Mills E. Godwin, Jr. Papers, 1712/1989, bulk 1947/19891
- Myron Schmall Collection, 1711/18151
- Overton family papers, 1727/1961, bulk 1781/18751
- Richard Billups Papers, 1705/1857, bulk 1774/18221
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Robert Morton Hughes Papers, 1715/1940, bulk 1871/19331
- Robertson Family Papers, 1730/19501
- Robinson Family Papers, 1725/1940, bulk 1793/18481
- Short Papers, 1675/17891
- Ted and Mary Wendell early American collection, 1721/18261
- Thomas G. and Louise Rowe Pullen Collection, 1655/17911
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071