- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Archibald Woods Papers, 1777/1846, bulk 1783/18461
- Armistead-Cocke Papers, 1680/19171
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/18921
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20231
- Borland Family Papers, 1771/19401
- Catesby Jones Account Book, 1767/18451
- Commencement Exercises collection, 1831/20241
- Dew Family papers, 1794/18951
- Faculty Assembly Records, 1729/20081
- Ferdinand Stewart Campbell Papers, 1825/18341
- George Frederick Holmes Papers, 1790/1898, bulk 1842/18871
- Gregory Family papers, 1829/1920, bulk 1880/19001
- Grigsby-Galt Papers, 1736/1982, bulk 1840/19301