- Administration records collection, 1776/19761
- Armistead Boothe Papers (MS164), 1803/19901
- Baer Family Papers, 1744/19291
- Cazenove Family Papers (MS212), 1786/19701
- Charles Edward Gary, Jr. Papers, 1870/2000, bulk 1940/19801
- Charlottesville Woolen Mills records, 1868/19561
- Daniel O'Sullivan Collection (MS141), 1850/19123
- Esther Holliday Green Collection (MS073), 1859/19821
- Goss family papers, 1820/2014, bulk 1820/19301
- Hugh Starke Morrison Account Book, 1871/18761
- Jefferson Society records, 1825/20181
- McHone Brothers (LLC) Collection of Houck Tannery Records, 1870/19131
- Molly Elliot Seawell Papers, 1859/2001, bulk 1889/19161
- Mt. Vernon Cotton Factory Collection (MS097), 1866/18751
- Robert H. and Lorraine Strickler Collection of John Zigler Daybooks, 1816/19031