- Rice Hotinger ledger and papers, 1931/19711
- Robb-Bernard Papers, 1665/1980, bulk 1850/19501
- Rose, Redd, and Claiborne family papers, 1771/20091
- Rupp Family papers, 1831/19731
- Rush Dew Holt Family Papers, 1820/20131
- S. George Company Records, 1900/19751
- Saint Andrew's Society collection, 1861/19951
- Salvation Army Combined Corps Roll and Ledger, 1926/1980, bulk 1928/19691
- Stratford Players Records, 1920/19831
- Tazewell Family Papers, 1838/1978, bulk 1860/18701
- Thoney Pietro, Contractor, Papers, 1867/19821
- United Glass and Ceramic Workers of America Local Union No. 2 (Clarksburg, WV) Papers, 1934/19741
- United Toy Workers Union, Local 149, Archives, 1941/19661
- Vaiden Family Papers, 1799/19821
- Vinyard Family Papers, 1781/1999, bulk 1915/19551