- Clarence Edwin Smith (1885-1959) Papers, 1787/19572
- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Alexander Haight family collection, 1764/19761
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Andrew Jackson Dadisman (1881-1965), Agricultural Economics Professor, Papers, 1914/19631
- Association of Women Students, Minute Books, 1927/19661
- Bell Hospital Records, 1926/19701
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bozarth Family Papers, 1931/1985, bulk 1931/19621
- Chappelear Collection, 1788/19591
- Chesapeake Western Railway Company Records, 1916/19821
- David B. Reger, Geologist, Records, 1931/19571
- Davis and Bower City Meat Market (Charleston, Ill.) Account Book, 1875-1878, 1875/19781
- Davis, Kline, and Hutton Family papers, 1816/19771
- Diggs Family Papers, 1914/1960, bulk 1920/19401