- Blacksville Store and Gristmill Business Records, 1850/19081
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bowman Collection Papers, 1885/19061
- Bozarth and Warburton Ledger, 1898/19101
- Brooke County (W. Va.) Court Records and Miscellaneous Papers, 1780/19181
- Butcher Memorandum Book, 1850/18991
- Byers Family Papers, 1806/19291
- C. B. Anderson Records, 1884/19101
- C. L. Leake and Company Account Books, 1882/19001
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1847/19011
- Carleton Custer Pierce (1877-1958) Papers, 1840/19551
- Chappelear Collection, 1788/19591
- Charles Brinkman, Collector, Papers, 1852/19521