- Alexander Haight family collection, 1764/19761
- Andrew Reid Account Book, 1787/18371
- Archibald Stuart Ledgers, 1757/18521
- Armistead-Cocke Papers, 1680/19171
- Austin-Twyman Papers, 1765/19391
- B. J. Spruell Account Book, 1782/18361
- Baer Family Papers, 1744/19291
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Brooke County (W. Va.) Court Records and Miscellaneous Papers, 1780/19181
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Catesby Jones Account Book, 1767/18451
- Charles Campbell Papers, 1743/18961
- Christopher Tompkins Papers, 1778/18381