- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18655
- The University of Virginia Jefferson Papers, 1751/18983
- Hugh Carr family papers and River View Farm, 1843/19782
- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/18971
- C. Harrison Mann, Jr. Map Collection, 1579/19611
- Claude Moore Health Sciences Library records, 1848/2019, bulk 1942/20251
- John Augustine Washington III and Mount Vernon Ladies' Association (MVLA) collection, 1834/19571
- Papers of the Massie Family of Virginia, 1850/19051
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Sarah Tracy Collection, 1859/18681
- The University of Virginia Collection on the History of Childhood, Parenting, and Family Building., 1700/20141
- University of Virginia Medical Center records, 1857/20241
- University of Virginia Medical Illustrations collection, 1760/1969, bulk 01
- University of Virginia School of Medicine records, 1825/20201
- Watts family papers-addition, 1786/19501