- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/18971
- Beebe collection of Washington family papers, 1818/1861, bulk 1840/18501
- C. Harrison Mann, Jr. Map Collection, 1579/19611
- Claude Moore Health Sciences Library records, 1848/2019, bulk 1942/20251
- Hugh Carr family papers and River View Farm, 1843/19781
- Jane Charlotte Blackburn Washington and John Augustine Washington III correspondence, 1837/18611
- John Augustine Washington III and Eleanor Love Selden correspondence, 1842/18603
- John Augustine Washington III and Mount Vernon Ladies' Association (MVLA) collection, 1834/19573
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18654
- Papers of the Massie Family of Virginia, 1850/19051
- Papers of the Randolph Family of Edgehill and Wilson Cary Nicholas, 1765/18691
- Papers of the Randolph Family of Edgehill, 1732/18607
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Record Book Listing of Enslaved People of the Massie Family, 1823/18631
- Sarah Tracy Collection, 1859/18687