- Papers of the Randolph Family of Edgehill, 1732/186014
- Papers of the Randolph Family of Edgehill and Wilson Cary Nicholas, 1765/18697
- John Augustine Washington III and Mount Vernon Ladies' Association (MVLA) collection, 1834/19573
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18653
- The University of Virginia Jefferson Papers, 1751/18983
- Record Book Listing of Enslaved People of the Massie Family, 1823/18632
- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/18971
- Beebe collection of Washington family papers, 1818/1861, bulk 1840/18501
- C. Harrison Mann, Jr. Map Collection, 1579/19611
- Jane Charlotte Blackburn Washington and John Augustine Washington III correspondence, 1837/18611
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- The University of Virginia Collection on the History of Childhood, Parenting, and Family Building., 1700/20141
- University of Virginia Medical Illustrations collection, 1720/1969, bulk 01
- University of Virginia School of Medicine records, 1825/20201
- Watts family papers-addition, 1786/19501