- Anna Maria Hickman Otis Mead Chalmers family papers, 1821/18971
- Beebe collection of Washington family papers, 1818/1861, bulk 1840/18501
- Bushrod Washington family papers, 1662/18352
- C. Harrison Mann, Jr. Map Collection, 1579/19611
- Chapin collection of Washington & Custis family documents, 1758/18292
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18653
- Papers of the Randolph Family of Edgehill and Wilson Cary Nicholas, 1765/186913
- Papers of the Randolph Family of Edgehill, 1732/186039
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Record Book Listing of Enslaved People of the Massie Family, 1823/18632
- The University of Virginia Collection on the History of Childhood, Parenting, and Family Building., 1700/20141
- The University of Virginia Jefferson Papers, 1751/18983
- University of Virginia Medical Illustrations collection, 1720/1969, bulk 02
- University of Virginia School of Medicine records, 1825/20201
- Watts family papers-addition, 1786/19501