- Bushrod Washington family papers, 1662/18351
- C. Harrison Mann, Jr. Map Collection, 1579/19611
- Chapin collection of Washington & Custis family documents, 1758/18291
- John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/18651
- Papers of the Randolph Family of Edgehill and Wilson Cary Nicholas, 1765/18691
- Papers of the Randolph Family of Edgehill, 1732/18601
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- The University of Virginia Collection on the History of Childhood, Parenting, and Family Building., 1700/20141
- The University of Virginia Jefferson Papers, 1751/18981
- University of Virginia Medical Illustrations collection, 1720/1969, bulk 01
- Watts family papers-addition, 1786/19501
- Wayne Rickert collection of founders' autographs, 1770/18311