The Artemis Sisters Collective was a feminist collective formed in September 1982 after an informal network of women had worked together to produce the Holly Near concert which was part of a Women and Health conference in Morgantown. Due to the enthusiasm generated by the concert, the Artemis Sisters decided to continue creating events featuring women's music in the Morgantown area. By combining creative, political, and social engagements the Artemis Sisters sought to promote women's empowerment.

The early years of the collective were focused on sponsoring events featuring musicians, comedians, poets, and story tellers. Some musical acts and entertainers included Holly Near, Robin Flowers and Company, Robin Tyler, Sweet Honey and the Rock, ALIVE!, Hazel Dickens, and Deidre McCalla.

Almost immediately upon the group's formation, efforts were made to engage with the community politically and socially. Besides their interest in promoting creative and social pursuits, the Artemis Sisters became involved with political issues through committees and projects, including the Lorraine Momen Defense Committee, Stop Abuse of Womyn Project, Committee for Individual Rights, Justice in the House, People for Justice, Elizabeth Strickland Defense Committee, and the Linda Conway Defense Committee.

Members of the Artemis Sisters began their foray into activism with the Lorraine Momen Defense Committee in 1983, which sought to defend Lorraine Momen against the charge of murder of her husband, Wayman Momen, based upon the evidence of domestic abuse and self-defense. The Defense Committee engaged in community education activities to increase public awareness of family violence through leafletting, public meetings, media work, outreach, and event sponsoring. This committee developed into the Stop Abuse of Womyn Project (SAW) to support women facing violence more generally and educate the public on issues such as sexual assault, pornography, and domestic violence.

Artemis members ran a radio show, , focused on curating playlists of women's music, interviewing women from West Virginia, and reporting current events pertaining to women's lives. Something About the Women was aired on the West Virginia University student radio station and was instrumental in spreading news about Artemis activities among the University community.

Additionally, a gathering space and lending library called SisterSpace Collective was opened on December 3rd, 1983, to focus on creating spaces where women could learn and engage with other women in the community regardless of race, age, class, or sexual preference. The Sisterspace Collective was housed at 235 High Street in Morgantown and promoted and engaged with a wide variety of activities including hosting the Gay Alcoholics Anonymous and Gay and Lesbian Alliance (GALA) student group, Lesbian Incest & Rape Survivors Group and Gay Alanon. Although created by members of the Artemis Sisters, SisterSpace eventually became its own independent organization while maintaining close connections with Artemis due to the substantial number of women who were involved in both operations. The SisterSpace Collective worked with the National Organization for Women, Retired School Employees Association, Womens' Studies Program, West Virginia University School of Social Work, some members of the West Virginia Education Association, Womens' Information Center, and the Citizens' Action Group. They also collaborated with the local Morgantown Woman to Woman, Inc. group to host a Women's Help Line.

The Committee for Individual Rights was formed by the Artemis Sisters in response to the 1983 Opinion by West Virginia Attorney General, Chauncey Browning, that rumor and reputation may be used as criteria in determining fitness of schoolteachers. In 1986, the Artemis Sisters worked with GALA of West Virginia University in its hosting of the first West Virginia Gay and Lesbian Conference in West Virginia. The People for Justice Committee sought to support Betty Justice in her candidacy for the West Virginia House of Delegates.

In 1987, after almost four years of operation, the SisterSpace Collective chose to close its doors due to a lack of volunteers, library users, and meeting attendance. Despite the shuttering of the Artemis Collective upon the closing of SisterSpace, the members of the intertwined committees and collectives remained in contact and held reunions in 1990, 1993, and 2016.