M'Ledge Moffett was born in 1892, the only child of William Ledgerwood Moffett and Mary Stoops Moffett. The name M'Ledge was formed from shortened versions of her parents names, Mary and Ledgerwood. She was hired at what is now Radford University in 1913 by President J.P McConnell as the youngest faculty member and the only member of the Household Arts Department. For the first several years after the college opened, Moffett taught all of the Household Arts courses (Elementary Sewing, Elementary Cooking and Household Management) which met five times a week.

In 1920, the Radford Normal School was reorganized and McConnell appointed Moffett as the new Dean of Women, a year before she received her Master of Arts degree. She was the first person to hold that post at any of the Virginia institutions of higher education. During the World War II years (1941-45) she was active in community and college defense planning and preparation. She was a leader in the community Civilian Mobilization program and was active in planning and educating the community about Victory Gardens. This collection contains official publications, correspondence, memoranda, and documents related to Victory Gardens, the Red Cross, Civilian Mobilization, Child Care, Nutrition, and other topics related to the domestic front at Radford College and the city of Radford during World War II. She held the Dean's post until her retirement in 1962. She died in 1969.