The Lucy Lee Lancaster Papers are divided into five series.

Series I: Biographical Materials is divided into general groupings of information about Lancaster and her family. Materials are not organized at a folder level. Information includes personal items such as class notes from grade school through graduate school, ephemera such as membership cards and poetry, photographs, and materials belonging to other family members. There are several family bibles and photographs. [These were formerly boxes 1-13 of the Personal Biographical Materials grouping.]

Series II: Correspondence contains personal correspondence as well as work-related materials regarding administration, reference questions, and bibliographies. Correspondence is arranged chronologically. There are also many postcards. Postcards sent to Lancaster are arranged by date, while those she collected as souvenirs are arranged alphabetically by place. [These were formerly boxes 1-14 of the Correspondence grouping.]

Series III: Genealogy Materials is listed in two subseries but stored alphabetically. While the focus is mostly research about various family members and branches, there is also material about family reunions and general genealogy research and workshops. [These were formerly boxes 1-5 of the Genealogy grouping.]

Series IV: Membership Organization Materials is arranged alphabetically by name of organization. It include papers from many groups in Blacksburg as well as VPI associations. Lancaster often served as secretary in the groups, so minutes and correspondence are present. [These were formerly boxes 1-7 of the Memberships grouping.]

Series V: Travel Materials includes notes and diaries from extensive travel that are arranged chronologically. These include initial correspondence sent to inquire about a place, itineraries, journals, receipts for purchases, and photographs. [These were formerly boxes 1-4 of the Travel grouping.]