Prince George County was named for Prince George of Denmark, husband of Queen Anne of England. It was formed from Charles City County by a statute adopted on 28 August 1702 to take effect on 23 April 1703. The county seat is Prince George.

In 1780 the Virginia General Assembly replaced the Anglican vestries and churchwardens of the colonial period with elected bodies called Overseers of the Poor. The Overseers provided food, clothing, shelter, and medical treatment for the persons who were too poor to support themselves or too ill to provide for their basic needs. They also bound out children whose parents could not support them or who failed to educate or instruct them, as well as orphans to become apprentices. The boys learned a trade and the girls learned domestic skills.

Most court records were destroyed in 1782 by British troops during the Revolutionary War and again in 1864 by Union troops during the Civil War. A few volumes that record deeds, court orders, and wills exist.