Lancaster County was probably named for the English county. It was formed from Northumberland and York Counties in 1651

The Timothy Division No. 152 of the Sons of Temperance was constituted at Lancaster Court House 1848 July 27. The Sons of Temperance, a total abstinence society, was founded in New York in 1842. The fraternal order provided assistance for its members, both in remaining temperate, and as a mutual aid society. More broadly, they promoted the societal benefit of abstinence and temperance. In contrast to its immediate predecessor, the Washington Movement, the Sons recruited members from among those already well affected to their cause. Though they refrained from taking public stances on religious and political matters, they did advocate ending the temptation by stopping the production and sale of alcohol. As a mutual aid society, the Sons of Temperance doled out sickness and disability benefits and allotted money to assist with the burial of fellow brothers and their wives. The attractiveness of its benefits led the organization to operate as a secret society, with stringent rules and a highly restricted membership. Allegations of intemperance and other transgressions were routinely investigated and often led to expulsion from the organization.