Northampton County (Va.) Commonwealth Causes, 1722-1816 are criminal court cases and consist primarily of warrants, summons, indictments, and verdicts handed down by grand juries and other legal authorities in order to prosecute individuals who violated the penal code. These offenses ranged in severity from murder, rape, assault and battery, and larceny to tax evasion and slander. Criminal offenders and victims who appear in cases prior to the abolition of slavery in Virginia in 1865 included both free and enslaved persons. Commonwealth causes specifically involving enslaved or freed persons prior to the abolition of slavery are in Box 1. Presentments and other types of documents referencing enslaved or freed people are among general Commonwealth Causes. Causes relating to alleged plots of insurrections of enslaved people in 1750, 1792, and 1812 are also present.

Warrants were issued by grand juries, judges, and justices of the peace directing law enforcement officials to either arrest and imprison a person suspected of having committed a crime or to cause an individual to appear in court to answer accusations made against them. Peace warrants directing an offender to "keep the peace of the Commonwealth" or to restrain from any violent acts are commonly found in assault and battery cases.

Summonses were used to call a suspected person to appear in court. A summons could also be issued to direct witnesses or victims to come before the court in order to provide evidence or information deemed pertinent to a case.

An indictment is the official, written description of the crime that an accused individual is suspected of committing, which is approved by a grand jury and presented to a court in order to begin legal proceedings. Due to this process, indictments are often referred to as "presentments."

Verdicts are the formal pronouncements made by juries on issues submitted to them by a judge or other law enforcement official. In the case of a guilty verdict, a judge will sentence the offender. Sentences may include a fine, corporal punishment, and/or imprisonment. Coroners also submitted verdicts such as "death by suicide," "death by natural causes," etc. when determining the cause of a suspicious or sudden death.