- A. H. Hand Papers, 1835/20091
- A. K. Leake Papers, 1872/19401
- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661
- Abraham Lincoln Ephemera from England, 1909/19301
- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Adele Blow Chatfield-Taylor family papers, 1899/19771
- African American Family Photographs, 1880/19601
- Albert C. Swindler Papers, 1862/1929, bulk 1862/18641
- Alexander, Grand Duke of Russia, Letter to Jonathan Myers, 19251
- Allen-Kean-Laurence family letters, 1837/19601
- Alma Fontaine Papers, 1923/19261
- Alumni Association Records, 1833/2014, bulk 1950/20051
- Alvin D. Chandler Naval Record, 1925/19511
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/19601
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/19791