{"links":{"self":"https://search.arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1906\u0026f%5Blevel%5D%5B%5D=Item\u0026page=223","prev":"https://search.arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1906\u0026f%5Blevel%5D%5B%5D=Item\u0026page=222","next":"https://search.arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1906\u0026f%5Blevel%5D%5B%5D=Item\u0026page=224","last":"https://search.arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1906\u0026f%5Blevel%5D%5B%5D=Item\u0026page=244"},"meta":{"pages":{"current_page":223,"next_page":224,"prev_page":222,"total_pages":244,"limit_value":10,"offset_value":2220,"total_count":2439,"first_page?":false,"last_page?":false}},"data":[{"id":"vilxw_repositories_5_resources_762_c01","type":"Item","attributes":{"title":"\"The Beautiful Caverns of Luray\", Luray, Virginia, 1906","breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/vilxw_repositories_5_resources_762_c01#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"vilxw_repositories_5_resources_762_c01","ref_ssm":["vilxw_repositories_5_resources_762_c01"],"id":"vilxw_repositories_5_resources_762_c01","ead_ssi":"vilxw_repositories_5_resources_762","_root_":"vilxw_repositories_5_resources_762","_nest_parent_":"vilxw_repositories_5_resources_762","parent_ssi":"vilxw_repositories_5_resources_762","parent_ssim":["Virginia Tourism Collection, 1906/2000"],"parent_ids_ssim":["vilxw_repositories_5_resources_762"],"title_filing_ssi":"\"The Beautiful Caverns of Luray\", Luray, Virginia","title_ssm":["\"The Beautiful Caverns of Luray\", Luray, Virginia"],"title_tesim":["\"The Beautiful Caverns of Luray\", Luray, Virginia"],"normalized_title_ssm":["\"The Beautiful Caverns of Luray\", Luray, Virginia, 1906"],"text":["\"The Beautiful Caverns of Luray\", Luray, Virginia, 1906","Virginia Tourism Collection, 1906/2000","English"],"parent_unittitles_ssm":["Virginia Tourism Collection, 1906/2000"],"parent_unittitles_tesim":["Virginia Tourism Collection, 1906/2000"],"normalized_date_ssm":["1906"],"unitdate_other_ssim":["1906"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[1],"sort_isi":1,"repository_ssim":["Washington and Lee University, Leyburn Library"],"collection_ssim":["Virginia Tourism Collection, 1906/2000"],"extent_ssm":["1 Volumes"],"extent_tesim":["1 Volumes"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_terms_tesm":["The materials from Washington and Lee University Special Collections are made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. 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Leyburn Library, Washington and Lee University, Lexington, VA\u003cp\u003eIn some cases the citation format may vary. Please contact Special Collections' staff to verify the appropriate format.\u003c/p\u003e\u003c/p\u003e "],"prefercite_tesim":["[Identification of item], Virginia Tourism Collection, WLU Coll. 0614, Special Collections and Archives, James G. Leyburn Library, Washington and Lee University, Lexington, VA In some cases the citation format may vary. 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The user assumes full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used should be fully credited with the source. Permission for publication of this material, in part or in full, must be secured with the Head of Special Collections.\u003c/p\u003e "],"userestrict_heading_ssm":["Conditions Governing Use"],"userestrict_tesim":["The materials from Washington and Lee University Special Collections are made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. The user assumes full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used should be fully credited with the source. Permission for publication of this material, in part or in full, must be secured with the Head of Special Collections."],"physloc_html_tesm":["\u003cphysloc id=\"aspace_95b48b0bb54e7882bcea98ecef0ca651\"\u003eWLU Coll. 0580-0614 are housed in a box together.\u003c/physloc\u003e\n "],"physloc_tesim":["WLU Coll. 0580-0614 are housed in a box together."],"corpname_ssim":["Washington and Lee University, University Library Special Collections and Archives","United States. National Park Service"],"names_ssim":["Washington and Lee University, University Library Special Collections and Archives","United States. National Park Service"],"language_ssim":["English"],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":9,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:38:39.199Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/vilxw_repositories_5_resources_762_c01"}},{"id":"viu_viu00186_c01_c04","type":"Item","attributes":{"title":"The Book of Elizabethan Verse: Letters and related items, 1906/1935","breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/viu_viu00186_c01_c04#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_viu00186_c01_c04","ref_ssm":["viu_viu00186_c01_c04"],"id":"viu_viu00186_c01_c04","ead_ssi":"viu_viu00186","_root_":"viu_viu00186","_nest_parent_":"viu_viu00186_c01","parent_ssi":"viu_viu00186_c01","parent_ssim":["William Stanley Braithwaite Papers \n 1882-1970","SERIES I: MANUSCRIPTS OF \n WILLIAM STANLEY\n BRAITHWAITE"],"parent_ids_ssim":["viu_viu00186","viu_viu00186_c01"],"title_filing_ssi":"The Book of Elizabethan Verse: Letters and related items","title_ssm":["The Book of Elizabethan Verse: Letters and related items"],"title_tesim":["The Book of Elizabethan Verse: Letters and related items"],"normalized_title_ssm":["The Book of Elizabethan Verse: Letters and related items, 1906/1935"],"text":["The Book of Elizabethan Verse: Letters and related items, 1906/1935","William Stanley Braithwaite Papers \n 1882-1970","SERIES I: MANUSCRIPTS OF \n WILLIAM STANLEY\n BRAITHWAITE","Box Box 1"],"parent_unittitles_ssm":["William Stanley Braithwaite Papers \n 1882-1970","SERIES I: MANUSCRIPTS OF \n WILLIAM STANLEY\n BRAITHWAITE"],"parent_unittitles_tesim":["William Stanley Braithwaite Papers \n 1882-1970","SERIES I: MANUSCRIPTS OF \n WILLIAM STANLEY\n BRAITHWAITE"],"normalized_date_ssm":["1906/1935"],"unitdate_other_ssim":["1906-1907, 1910 \u0026 1935"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[2],"sort_isi":5,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["William Stanley Braithwaite Papers \n 1882-1970"],"containers_ssim":["Box Box 1"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["Collection is open to research."],"parent_access_terms_tesm":["See the \n \n University of Virginia Library’s use policy."],"date_range_isim":[1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935],"_nest_path_":"/components#0/components#3","timestamp":"2026-08-14T22:55:49.050Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_viu00186","ead_ssi":"viu_viu00186","_root_":"viu_viu00186","_nest_parent_":"viu_viu00186","ead_source_url_ssi":"data/uva-sc/viu00186.xml","title_ssm":["William Stanley Braithwaite Papers \n 1882-1970"],"title_tesim":["William Stanley Braithwaite Papers \n 1882-1970"],"normalized_title_ssm":["William Stanley Braithwaite Papers \n 1882-1970"],"text":["William Stanley Braithwaite Papers \n 1882-1970","8990-b","7 ft.","Collection is open to research.","BIOGRAPHICAL CHRONOLOGY OF WILLIAM STANLEY\n BRAITHWAITE\n \n 1875\n Marriage of \n William Stanley Braithwaite's\n parents \n Emma DeWolfe (1860-1928)and \n William Smith Braithwaite\n (1853-1886)\n \n \n 1876\n Birth of \n William Stanley Braithwaite's\n sister, \n Eva Braithwaite\n \n \n 1878\n Birth of \n William Stanley Braithwaitein \n Boston, Massachusettson 6\n December\n \n \n 1885\n Birth of a sister; she dies in \n 1894\n \n \n 1886\n Death of \n William Stanley Braithwaite's\n father\n \n \n 1889\n Map of \n Europedrawn by \n William Stanley Braithwaiteis\n exhibited at the \n Parisfair\n \n \n 1890\n William Stanley Braithwaite, age\n 12, obtains first job (selling newspapers in \n Boston)\n \n \n 1898\n William Stanley Braithwaitemanages\n a \n Newport, Rhode\n Islandbookstore\n \n \n 1901\n Publishes first novel, \n The Canadian, A Novel\n \n \n 1903\n Marries \n Emma Kellyon 30 June; seven\n children: \n Fiona Lydia Rossetti\n Braithwaite(Mrs. \n Merrill Carter), \n Katherine Keats Braithwaite(Mrs. \n William J. Arnold), \n William Stanley Braithwaite, Jr., \n Edith Carman Braithwaite(Mrs.\n Agard), \n Paul Ledoux Braithwaite, \n Arnold DeWolfe Braithwaite, \n Francis Robinson\n Braithwaite\n \n \n 1904\n Publishes \n Lyrics of Life and Love\n \n \n 1906\n Edits \n The Book of Elizabethan Verse; elected to the \n Boston Author's Clubwith the\n support of \n Thomas Wentworth Higginsonand \n Julia Ward Howe; begins writing for\n the \n Boston Evening Transcripton 14 February; he reviews American poetry and\n poets and writes essays\n \n \n 1907\n William Stanley Braithwaitepoem\n \"White Magic\", honoring \n John Greenleaf Whittier, is read by\n Braithwaite at Faneuil Hall, \n Boston, Massachusettson 17\n December\n \n \n 1908\n Publishes \n The House of Falling Leaves; writes an essay introduction for \n The Wounded Eros: Sonnetsby Charles Gibson\n \n \n 1909\n Publishes poem \"Sandy Star\" in the July issue of \n Atlantic Monthly; also edits \n The Book of Georgian Verse\n \n \n 1909-1910\n Plans \n \"The Book of Victorian Verse\"but it is never published\n \n \n 1910\n Edits \n The Book of Restoration Verse\n \n \n 1912-1914\n Sporadically publishes and edits \n Poetry Journaluntil it is taken over by others\n \n \n 1913-1929\n Edits \n Anthology of Magazine Verse and Yearbook of\n American Poetry For The Year . . .until 1929\n \n \n 1915\n William Stanley Braithwaitepoem\n \"The Mystery\" is published in the October issue of \n Scribners; literary criticism by Braithwaite is\n published in \n The Poetry Journal, \n \"Poetry of The Public\"; he organizes the \n New England Poetry Clubwith \n Edward J. O'Brien\n \n \n 1916\n Edits \n Representative American Poetrywith \n Henry Thomas Schittkind; also edits\n The Poetic Year For 1916and \n The Poets of The Future: A College Anthology\n of 1915/16\n \n \n 1916-1917\n Edits \n The Stratford Monthlywith \n Henry Thomas Schnittkind\n \n \n 1917\n Plans a book, \n \"The Seven Wisdoms of Grainne\"but does not complete it; accepts honorary\n membership in \n Alpha Phi Alpha fraternity\n \n \n 1918\n Awarded the Spingarn Medal, \n First Baptist Church, \n Providence, Rhode Island, during a\n meeting of the \n National Association For The Advancement of\n Colored People(NAACP) on 3 May for\n \"distinguished achievement in literature\"; edits \n The Golden Treasury of Magazine Verse; awarded an honorary A. M. (Masters) degree\n from \n Atlanta Universityfor his poetry\n and a Litt.D. from \n Talladega College; writes\n introduction to \n The Heart of A Woman And Other Poemsby \n Georgia D. Johnson\n \n \n 1919\n Publishes \n The Story of The Great War; edits \n Victory! Celebrated By Thirty-eight American\n Poets; literary criticism published in \n The Crisis, \"Some Contemporary Poets of The Negro Race\";\n edits \n The Book of Modern British Verse\n \n \n 1920\n Publishes \n Our Essayists And Critics Today\n \n \n 1921\n Writes introduction to \n The Beggars' Visionby \n Brookes More; publishes poetry\n volume, \n A Tale Of A Walled Town And Other\n Verses\n \n \n 1921-1927\n Founds and becomes editor-in-chief of \n B. J. Brimmer Publishing\n Companywith \n Winifred Jacksonas a partner and\n company treasurer; she buys the company in 1925, the\n same year of its bankruptcy(?) (Several documents in the\n collection indicate the company may have remained\n solvent until 1929.)\n \n \n 1922\n William Stanley Braithwaiteedits \n Anthology of Massachusetts Poets; \n B. J. Brimmerpublishes \n Bronze: A Book of Verseby \n Georgia Douglas Johnson\n \n \n 1924\n B. J. Brimmerpublishes \n Confusionby \n James Gould Cozzens; \n William Stanley\n Braithwaitepublishes \"The New Negro In\n Literature\" in \n The Crisis, and, \n Going Over Tindal, A Novel\n \n \n 1928\n Death of \n William Stanley Braithwaite's\n mother; he publishes a book of stories, \n Frost On The Green Leaf\n \n \n 1931\n Edits \n Our Lady's Choir: A Contemporary Anthology of\n Verses By Catholic Sisters\n \n \n 1934\n Literary criticism, \"The Novels of Jessie Faust,\"\n published in \n Opportunity\n \n \n 1934-1935\n Appointed Professor of Creative Literature at \n Atlanta University; retires in\n 1945\n \n \n 1935\n Alan F. Peterof the \n Poetry Digest Associationplans a\n 1935 issue of \n Anthology of Magazine Verseand offers \n William Stanley Braithwaitethe\n opportunity of providing editorial assistance\n \n \n 1936\n William Stanley Braithwaitewrites\n introduction to \n We Lift Our Voices And Other Poemsby \n Mae V. Cowdery\n \n \n 1937\n Sterling Brown, in \n Negro Poetry \u0026 Drama, praises \n William Stanley Braithwaiteas a\n poetry critic\n \n \n 1938\n William Stanley Braithwaiteserves\n on a program committee for the \n Association of Teachers of English in Negro\n Colleges(later \n The College Language\n Association)\n \n \n 1939\n Death of \n William Stanley Braithwaite's\n paternal uncle, \n Edward John Braithwaite, age 85, in\n September\n \n \n 1940\n William Stanley\n Braithwaitepublishes \n The Years Between 1918-39and \n Poems, New and Selected\n \n \n 1941-1942\n William Stanley Braithwaite's\n autobiography, \n \"The House Under Acturus\"is serialized in five installments in \n Phylonduring 1942; it tells the story of his life up\n to the publication of his first book of poems in\n 1904\n \n \n 1942\n An M. A. thesis by \n Alma Westine Stoneof \n Atlanta Universityexamines \n William Stanley Braithwaite's\n career\n \n \n 1945\n Retires from \n Atlanta Universityand moves to \n Harlem, New York City\n \n \n 1947\n Publishes an article in \n Negro Digest, \"Negro America's First Magazine\"\n \n \n 1948\n Publishes \n Selected Poems\n \n \n 1950\n Publishes \n The Bewitched Parsonage: The Story of The\n Brontes\n \n \n 1956\n Interviewed by \n Columbia University's Oral History Research\n Officefrom May to June: \n \"The Reminiscences of William S.\n Braithwaite\"\n \n \n 1957\n Literary criticism published in \n Phylon, \"Alain Locke's Relationship To The Negro In\n American Literature\"; death of \n William Stanley Braithwaite's\n brother Arthur on 24 September\n \n \n 1958\n Co-edits 1958 \n Anthology of Magazine Versewith \n Margaret Carpenter, a \n Norfolk, Virginia, poet and\n admirer; it includes a selection of poetry from the\n previous anthologies; \n William Stanley Braithwaite's\n efforts are hampered by his failing eyesight\n \n \n 1959\n An \n American Poetry Societydinner is\n held in \n William Stanley Braithwaite's honor\n in \n New York City; he writes the\n preface to \n A Voice In Ramah: Poemsby \n Marion Buchman\n \n \n 1962\n Death of \n William Stanley Braithwaite, age\n 83, on 8 June in \n New York City; funeral held on 12\n June","Funded in part by a grant from the National Endowment\n for the Humanities","See the \n \n University of Virginia Library’s use policy.","University of Virginia. Library. Special\n Collections Dept.","Boston Author's Club","New England Poetry Club","Alpha Phi Alpha fraternity","First Baptist Church","National Association For The Advancement of\n Colored People","Atlanta University","Talladega College","B. J. Brimmer Publishing\n Company","B. J. Brimmer","Poetry Digest Association","Association of Teachers of English in Negro\n Colleges","The College Language\n Association","Columbia University's Oral History Research\n Office","American Poetry Society","Columbia University, Oral History Research\n Office","B. J. BRIMMER COMPANY","B. J. Brimmer Co.","Poetry Society","Author's League of America","New England Poetry\n Club","Brentano's","Order of Bookfellows","Peabody Master Printers","Poetry Society of America","Small, Maynard \u0026\n Company","Delta Phi Delta","Brimmer Books","Hampton Institute","Braithwaite Family","Braithwaite\n Family","William Stanley Braithwaite","Emma DeWolfe (1860-1928)","William Smith Braithwaite\n (1853-1886)","Eva Braithwaite","Emma Kelly","Fiona Lydia Rossetti\n Braithwaite","Merrill Carter","Katherine Keats Braithwaite","William J. Arnold","William Stanley Braithwaite, Jr.","Edith Carman Braithwaite","Paul Ledoux Braithwaite","Arnold DeWolfe Braithwaite","Francis Robinson\n Braithwaite","Thomas Wentworth Higginson","Julia Ward Howe","John Greenleaf Whittier","Edward J. O'Brien","Henry Thomas Schittkind","Henry Thomas Schnittkind","Georgia D. Johnson","Brookes More","Winifred Jackson","Georgia Douglas Johnson","James Gould Cozzens","William Stanley\n Braithwaite","Alan F. Peter","Mae V. Cowdery","Sterling Brown","Edward John Braithwaite","Alma Westine Stone","Margaret Carpenter","Marion Buchman","WILLIAM STANLEY\n BRAITHWAITE","William Stanley\n Braithwaite","Walt Whitman","Emma E. Colley","Winifred Davidson","Elizabeth Weston Timlow","Lewis Carroll","Evelyn H. Watson","Bella Flaccus","George H. P. Gannaway","William Stanley\n Braithwaite","Edmund Clarence Stedman","Leonora Speyer","Mark Van Doren","Vachel Lindsay","Arnold\n Braithwaite","Arnold DeWolfe\n Braithwaite","Edith Carman\n Braithwaite","Edward John\n Braithwaite","Emma DeWolfe\n Braithwaite","Emma Kelly\n Braithwaite","W. E. B. Du Bois","Stanley Braithwaite","Fiona Lydia\n Braithwaite","Francis Robinson\n Braithwaite","Katherine Keats\n Braithwaite","Paul Ledoux\n Braithwaite","William Stanley Braithwaite,\n Jr.","William Stanley Braithwaite,\n Jr.","Lillian K. Coleman","Lillian\n Valentine","Sadie De Wolfe\n (Braithwaite)","Sally Kelly","Lucy Williams","Richard G. Badger","Maurine Boie","Witter Bynner","Bliss Carman","Margaret\n Carpenter","Joy Gerbaulet Clairmonte","Ruby Rose Drake","Sophie Hagemann Duckworth","George Elliston","Eva Knox Evans","Ernst B. Filsinger","Elizabeth Hollister Frost","Marion P. Gale","Iva L. Handy","Henry E. Harman","John Hughes","Mitchell Kennerly","Helen Kent","Frederic Lawrence Knowles","Mary Sinton Leitch","Francis Mason","Edith Mirick","Winifred V.\n Jackson","Edwin Arlington Robinson","Edna Davis Romig","Lew Sarett","Sara Teasdale","Eunice Tietjens","Mary Pollard Tynes","Louis Untermeyer","Arthur Upson","Henry Van Dyke","Harold Vinal","Ovid","Clinton Scollard","Caroline Giltinan","Clive Bell","William Thackeray","William Dean Howells","Louis Hubert Guyol","English"],"collection_title_tesim":["William Stanley Braithwaite Papers \n 1882-1970"],"collection_ssim":["William Stanley Braithwaite Papers \n 1882-1970"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["8990-b"],"unitid_tesim":["8990-b"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_persname_ssim":["William Stanley Braithwaite","Emma DeWolfe (1860-1928)","William Smith Braithwaite\n (1853-1886)","Eva Braithwaite","Emma Kelly","Fiona Lydia Rossetti\n Braithwaite","Merrill Carter","Katherine Keats Braithwaite","William J. 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Brimmer Co.","Poetry Society","Author's League of America","New England Poetry\n Club","Brentano's","Order of Bookfellows","Peabody Master Printers","Poetry Society of America","Small, Maynard \u0026\n Company","Delta Phi Delta","Brimmer Books","Hampton Institute","Braithwaite Family","Braithwaite\n Family"],"access_terms_ssm":["See the \n \n University of Virginia Library’s use policy."],"acqinfo_ssim":["Gift, 1985 Jul 3"],"has_online_content_ssim":["false"],"physdesc_tesim":["7 ft."],"accessrestrict_html_tesm":["\u003cp\u003eCollection is open to research.\u003c/p\u003e\n "],"accessrestrict_heading_ssm":["Access Restrictions"],"accessrestrict_tesim":["Collection is open to research."],"bioghist_heading_ssm":["Biography"],"bioghist_tesim":["BIOGRAPHICAL CHRONOLOGY OF WILLIAM STANLEY\n BRAITHWAITE\n \n 1875\n Marriage of \n William Stanley Braithwaite's\n parents \n Emma DeWolfe (1860-1928)and \n William Smith Braithwaite\n (1853-1886)\n \n \n 1876\n Birth of \n William Stanley Braithwaite's\n sister, \n Eva Braithwaite\n \n \n 1878\n Birth of \n William Stanley Braithwaitein \n Boston, Massachusettson 6\n December\n \n \n 1885\n Birth of a sister; she dies in \n 1894\n \n \n 1886\n Death of \n William Stanley Braithwaite's\n father\n \n \n 1889\n Map of \n Europedrawn by \n William Stanley Braithwaiteis\n exhibited at the \n Parisfair\n \n \n 1890\n William Stanley Braithwaite, age\n 12, obtains first job (selling newspapers in \n Boston)\n \n \n 1898\n William Stanley Braithwaitemanages\n a \n Newport, Rhode\n Islandbookstore\n \n \n 1901\n Publishes first novel, \n The Canadian, A Novel\n \n \n 1903\n Marries \n Emma Kellyon 30 June; seven\n children: \n Fiona Lydia Rossetti\n Braithwaite(Mrs. \n Merrill Carter), \n Katherine Keats Braithwaite(Mrs. \n William J. Arnold), \n William Stanley Braithwaite, Jr., \n Edith Carman Braithwaite(Mrs.\n Agard), \n Paul Ledoux Braithwaite, \n Arnold DeWolfe Braithwaite, \n Francis Robinson\n Braithwaite\n \n \n 1904\n Publishes \n Lyrics of Life and Love\n \n \n 1906\n Edits \n The Book of Elizabethan Verse; elected to the \n Boston Author's Clubwith the\n support of \n Thomas Wentworth Higginsonand \n Julia Ward Howe; begins writing for\n the \n Boston Evening Transcripton 14 February; he reviews American poetry and\n poets and writes essays\n \n \n 1907\n William Stanley Braithwaitepoem\n \"White Magic\", honoring \n John Greenleaf Whittier, is read by\n Braithwaite at Faneuil Hall, \n Boston, Massachusettson 17\n December\n \n \n 1908\n Publishes \n The House of Falling Leaves; writes an essay introduction for \n The Wounded Eros: Sonnetsby Charles Gibson\n \n \n 1909\n Publishes poem \"Sandy Star\" in the July issue of \n Atlantic Monthly; also edits \n The Book of Georgian Verse\n \n \n 1909-1910\n Plans \n \"The Book of Victorian Verse\"but it is never published\n \n \n 1910\n Edits \n The Book of Restoration Verse\n \n \n 1912-1914\n Sporadically publishes and edits \n Poetry Journaluntil it is taken over by others\n \n \n 1913-1929\n Edits \n Anthology of Magazine Verse and Yearbook of\n American Poetry For The Year . . .until 1929\n \n \n 1915\n William Stanley Braithwaitepoem\n \"The Mystery\" is published in the October issue of \n Scribners; literary criticism by Braithwaite is\n published in \n The Poetry Journal, \n \"Poetry of The Public\"; he organizes the \n New England Poetry Clubwith \n Edward J. O'Brien\n \n \n 1916\n Edits \n Representative American Poetrywith \n Henry Thomas Schittkind; also edits\n The Poetic Year For 1916and \n The Poets of The Future: A College Anthology\n of 1915/16\n \n \n 1916-1917\n Edits \n The Stratford Monthlywith \n Henry Thomas Schnittkind\n \n \n 1917\n Plans a book, \n \"The Seven Wisdoms of Grainne\"but does not complete it; accepts honorary\n membership in \n Alpha Phi Alpha fraternity\n \n \n 1918\n Awarded the Spingarn Medal, \n First Baptist Church, \n Providence, Rhode Island, during a\n meeting of the \n National Association For The Advancement of\n Colored People(NAACP) on 3 May for\n \"distinguished achievement in literature\"; edits \n The Golden Treasury of Magazine Verse; awarded an honorary A. M. (Masters) degree\n from \n Atlanta Universityfor his poetry\n and a Litt.D. from \n Talladega College; writes\n introduction to \n The Heart of A Woman And Other Poemsby \n Georgia D. Johnson\n \n \n 1919\n Publishes \n The Story of The Great War; edits \n Victory! Celebrated By Thirty-eight American\n Poets; literary criticism published in \n The Crisis, \"Some Contemporary Poets of The Negro Race\";\n edits \n The Book of Modern British Verse\n \n \n 1920\n Publishes \n Our Essayists And Critics Today\n \n \n 1921\n Writes introduction to \n The Beggars' Visionby \n Brookes More; publishes poetry\n volume, \n A Tale Of A Walled Town And Other\n Verses\n \n \n 1921-1927\n Founds and becomes editor-in-chief of \n B. J. Brimmer Publishing\n Companywith \n Winifred Jacksonas a partner and\n company treasurer; she buys the company in 1925, the\n same year of its bankruptcy(?) (Several documents in the\n collection indicate the company may have remained\n solvent until 1929.)\n \n \n 1922\n William Stanley Braithwaiteedits \n Anthology of Massachusetts Poets; \n B. J. Brimmerpublishes \n Bronze: A Book of Verseby \n Georgia Douglas Johnson\n \n \n 1924\n B. J. Brimmerpublishes \n Confusionby \n James Gould Cozzens; \n William Stanley\n Braithwaitepublishes \"The New Negro In\n Literature\" in \n The Crisis, and, \n Going Over Tindal, A Novel\n \n \n 1928\n Death of \n William Stanley Braithwaite's\n mother; he publishes a book of stories, \n Frost On The Green Leaf\n \n \n 1931\n Edits \n Our Lady's Choir: A Contemporary Anthology of\n Verses By Catholic Sisters\n \n \n 1934\n Literary criticism, \"The Novels of Jessie Faust,\"\n published in \n Opportunity\n \n \n 1934-1935\n Appointed Professor of Creative Literature at \n Atlanta University; retires in\n 1945\n \n \n 1935\n Alan F. Peterof the \n Poetry Digest Associationplans a\n 1935 issue of \n Anthology of Magazine Verseand offers \n William Stanley Braithwaitethe\n opportunity of providing editorial assistance\n \n \n 1936\n William Stanley Braithwaitewrites\n introduction to \n We Lift Our Voices And Other Poemsby \n Mae V. Cowdery\n \n \n 1937\n Sterling Brown, in \n Negro Poetry \u0026 Drama, praises \n William Stanley Braithwaiteas a\n poetry critic\n \n \n 1938\n William Stanley Braithwaiteserves\n on a program committee for the \n Association of Teachers of English in Negro\n Colleges(later \n The College Language\n Association)\n \n \n 1939\n Death of \n William Stanley Braithwaite's\n paternal uncle, \n Edward John Braithwaite, age 85, in\n September\n \n \n 1940\n William Stanley\n Braithwaitepublishes \n The Years Between 1918-39and \n Poems, New and Selected\n \n \n 1941-1942\n William Stanley Braithwaite's\n autobiography, \n \"The House Under Acturus\"is serialized in five installments in \n Phylonduring 1942; it tells the story of his life up\n to the publication of his first book of poems in\n 1904\n \n \n 1942\n An M. A. thesis by \n Alma Westine Stoneof \n Atlanta Universityexamines \n William Stanley Braithwaite's\n career\n \n \n 1945\n Retires from \n Atlanta Universityand moves to \n Harlem, New York City\n \n \n 1947\n Publishes an article in \n Negro Digest, \"Negro America's First Magazine\"\n \n \n 1948\n Publishes \n Selected Poems\n \n \n 1950\n Publishes \n The Bewitched Parsonage: The Story of The\n Brontes\n \n \n 1956\n Interviewed by \n Columbia University's Oral History Research\n Officefrom May to June: \n \"The Reminiscences of William S.\n Braithwaite\"\n \n \n 1957\n Literary criticism published in \n Phylon, \"Alain Locke's Relationship To The Negro In\n American Literature\"; death of \n William Stanley Braithwaite's\n brother Arthur on 24 September\n \n \n 1958\n Co-edits 1958 \n Anthology of Magazine Versewith \n Margaret Carpenter, a \n Norfolk, Virginia, poet and\n admirer; it includes a selection of poetry from the\n previous anthologies; \n William Stanley Braithwaite's\n efforts are hampered by his failing eyesight\n \n \n 1959\n An \n American Poetry Societydinner is\n held in \n William Stanley Braithwaite's honor\n in \n New York City; he writes the\n preface to \n A Voice In Ramah: Poemsby \n Marion Buchman\n \n \n 1962\n Death of \n William Stanley Braithwaite, age\n 83, on 8 June in \n New York City; funeral held on 12\n June"],"prefercite_html_tesm":["\u003cp\u003eWilliam Stanley Braithwaite\n Papers, Accession 8990-b, Special Collections Department, University of\n Virginia Library\u003c/p\u003e\n "],"prefercite_tesim":["William Stanley Braithwaite\n Papers, Accession 8990-b, Special Collections Department, University of\n Virginia Library"],"processinfo_html_tesm":["\u003cp\u003eFunded in part by a grant from the National Endowment\n for the Humanities\u003c/p\u003e\n "],"processinfo_heading_ssm":["Funding Note"],"processinfo_tesim":["Funded in part by a grant from the National Endowment\n for the Humanities"],"userestrict_html_tesm":["\u003cp\u003eSee the \n \u003cextref type=\"simple\" href=\"https://www.library.virginia.edu/policies/use-of-materials\"\u003e\n University of Virginia Library’s use policy.\u003c/extref\u003e\u003c/p\u003e\n "],"userestrict_heading_ssm":["Use Restrictions"],"userestrict_tesim":["See the \n \n University of Virginia Library’s use policy."],"physloc_html_tesm":["\u003cphysloc\u003e\u003c/physloc\u003e\n "],"corpname_ssim":["University of Virginia. 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Cowdery","Sterling Brown","Edward John Braithwaite","Alma Westine Stone","Margaret Carpenter","Marion Buchman","WILLIAM STANLEY\n BRAITHWAITE","William Stanley\n Braithwaite","Walt Whitman","Emma E. Colley","Winifred Davidson","Elizabeth Weston Timlow","Lewis Carroll","Evelyn H. Watson","Bella Flaccus","George H. P. Gannaway","William Stanley\n Braithwaite","Edmund Clarence Stedman","Leonora Speyer","Mark Van Doren","Vachel Lindsay","Arnold\n Braithwaite","Arnold DeWolfe\n Braithwaite","Edith Carman\n Braithwaite","Edward John\n Braithwaite","Emma DeWolfe\n Braithwaite","Emma Kelly\n Braithwaite","W. E. B. Du Bois","Stanley Braithwaite","Fiona Lydia\n Braithwaite","Francis Robinson\n Braithwaite","Katherine Keats\n Braithwaite","Paul Ledoux\n Braithwaite","William Stanley Braithwaite,\n Jr.","William Stanley Braithwaite,\n Jr.","Lillian K. Coleman","Lillian\n Valentine","Sadie De Wolfe\n (Braithwaite)","Sally Kelly","Lucy Williams","Richard G. Badger","Maurine Boie","Witter Bynner","Bliss Carman","Margaret\n Carpenter","Joy Gerbaulet Clairmonte","Ruby Rose Drake","Sophie Hagemann Duckworth","George Elliston","Eva Knox Evans","Ernst B. Filsinger","Elizabeth Hollister Frost","Marion P. Gale","Iva L. Handy","Henry E. Harman","John Hughes","Mitchell Kennerly","Helen Kent","Frederic Lawrence Knowles","Mary Sinton Leitch","Francis Mason","Edith Mirick","Winifred V.\n Jackson","Edwin Arlington Robinson","Edna Davis Romig","Lew Sarett","Sara Teasdale","Eunice Tietjens","Mary Pollard Tynes","Louis Untermeyer","Arthur Upson","Henry Van Dyke","Harold Vinal","Ovid","Clinton Scollard","Caroline Giltinan","Clive Bell","William Thackeray","William Dean Howells","Louis Hubert Guyol"],"language_ssim":["English"],"total_component_count_is":214,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:55:49.050Z","bioghist_html_tesm":["\u003cchronlist\u003e\n \u003chead\u003eBIOGRAPHICAL CHRONOLOGY OF WILLIAM STANLEY\n BRAITHWAITE\u003c/head\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1875\u003c/date\u003e\n \u003cevent\u003eMarriage of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n parents \n \u003cpersname\u003eEmma DeWolfe (1860-1928)\u003c/persname\u003eand \n \u003cpersname\u003eWilliam Smith Braithwaite\n (1853-1886)\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1876\u003c/date\u003e\n \u003cevent\u003eBirth of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n sister, \n \u003cpersname\u003eEva Braithwaite\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1878\u003c/date\u003e\n \u003cevent\u003eBirth of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003ein \n \u003cgeogname\u003eBoston, Massachusetts\u003c/geogname\u003eon 6\n December\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1885\u003c/date\u003e\n \u003cevent\u003eBirth of a sister; she dies in \n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1894\u003c/date\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1886\u003c/date\u003e\n \u003cevent\u003eDeath of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n father\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1889\u003c/date\u003e\n \u003cevent\u003eMap of \n \u003cgeogname\u003eEurope\u003c/geogname\u003edrawn by \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003eis\n exhibited at the \n \u003cgeogname\u003eParis\u003c/geogname\u003efair\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1890\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e, age\n 12, obtains first job (selling newspapers in \n \u003cgeogname\u003eBoston\u003c/geogname\u003e)\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1898\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003emanages\n a \n \u003cgeogname\u003eNewport, Rhode\n Island\u003c/geogname\u003ebookstore\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1901\u003c/date\u003e\n \u003cevent\u003ePublishes first novel, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Canadian, A Novel\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1903\u003c/date\u003e\n \u003cevent\u003eMarries \n \u003cpersname\u003eEmma Kelly\u003c/persname\u003eon 30 June; seven\n children: \n \u003cpersname\u003eFiona Lydia Rossetti\n Braithwaite\u003c/persname\u003e(Mrs. \n \u003cpersname\u003eMerrill Carter\u003c/persname\u003e), \n \u003cpersname\u003eKatherine Keats Braithwaite\u003c/persname\u003e(Mrs. \n \u003cpersname\u003eWilliam J. Arnold\u003c/persname\u003e), \n \u003cpersname\u003eWilliam Stanley Braithwaite, Jr.\u003c/persname\u003e, \n \u003cpersname\u003eEdith Carman Braithwaite\u003c/persname\u003e(Mrs.\n Agard), \n \u003cpersname\u003ePaul Ledoux Braithwaite\u003c/persname\u003e, \n \u003cpersname\u003eArnold DeWolfe Braithwaite\u003c/persname\u003e, \n \u003cpersname\u003eFrancis Robinson\n Braithwaite\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1904\u003c/date\u003e\n \u003cevent\u003ePublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eLyrics of Life and Love\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1906\u003c/date\u003e\n \u003cevent\u003eEdits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Book of Elizabethan Verse\u003c/title\u003e\u003c/bibref\u003e; elected to the \n \u003ccorpname\u003eBoston Author's Club\u003c/corpname\u003ewith the\n support of \n \u003cpersname\u003eThomas Wentworth Higginson\u003c/persname\u003eand \n \u003cpersname\u003eJulia Ward Howe\u003c/persname\u003e; begins writing for\n the \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eBoston Evening Transcript\u003c/title\u003e\u003c/bibref\u003eon 14 February; he reviews American poetry and\n poets and writes essays\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1907\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003epoem\n \"White Magic\", honoring \n \u003cpersname\u003eJohn Greenleaf Whittier\u003c/persname\u003e, is read by\n Braithwaite at Faneuil Hall, \n \u003cgeogname\u003eBoston, Massachusetts\u003c/geogname\u003eon 17\n December\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1908\u003c/date\u003e\n \u003cevent\u003ePublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe House of Falling Leaves\u003c/title\u003e\u003c/bibref\u003e; writes an essay introduction for \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Wounded Eros: Sonnets\u003c/title\u003e\u003c/bibref\u003eby Charles Gibson\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1909\u003c/date\u003e\n \u003cevent\u003ePublishes poem \"Sandy Star\" in the July issue of \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eAtlantic Monthly\u003c/title\u003e\u003c/bibref\u003e; also edits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Book of Georgian Verse\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1909-1910\u003c/date\u003e\n \u003cevent\u003ePlans \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003e\"The Book of Victorian Verse\"\u003c/title\u003e\u003c/bibref\u003ebut it is never published\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1910\u003c/date\u003e\n \u003cevent\u003eEdits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Book of Restoration Verse\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1912-1914\u003c/date\u003e\n \u003cevent\u003eSporadically publishes and edits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003ePoetry Journal\u003c/title\u003e\u003c/bibref\u003euntil it is taken over by others\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1913-1929\u003c/date\u003e\n \u003cevent\u003eEdits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eAnthology of Magazine Verse and Yearbook of\n American Poetry For The Year . . .\u003c/title\u003e\u003c/bibref\u003euntil 1929\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1915\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003epoem\n \"The Mystery\" is published in the October issue of \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eScribners\u003c/title\u003e\u003c/bibref\u003e; literary criticism by Braithwaite is\n published in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Poetry Journal\u003c/title\u003e\u003c/bibref\u003e, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003e\"Poetry of The Public\"\u003c/title\u003e\u003c/bibref\u003e; he organizes the \n \u003ccorpname\u003eNew England Poetry Club\u003c/corpname\u003ewith \n \u003cpersname\u003eEdward J. O'Brien\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1916\u003c/date\u003e\n \u003cevent\u003eEdits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eRepresentative American Poetry\u003c/title\u003e\u003c/bibref\u003ewith \n \u003cpersname\u003eHenry Thomas Schittkind\u003c/persname\u003e; also edits\n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Poetic Year For 1916\u003c/title\u003e\u003c/bibref\u003eand \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Poets of The Future: A College Anthology\n of 1915/16\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1916-1917\u003c/date\u003e\n \u003cevent\u003eEdits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Stratford Monthly\u003c/title\u003e\u003c/bibref\u003ewith \n \u003cpersname\u003eHenry Thomas Schnittkind\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1917\u003c/date\u003e\n \u003cevent\u003ePlans a book, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003e\"The Seven Wisdoms of Grainne\"\u003c/title\u003e\u003c/bibref\u003ebut does not complete it; accepts honorary\n membership in \n \u003ccorpname\u003eAlpha Phi Alpha fraternity\u003c/corpname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1918\u003c/date\u003e\n \u003cevent\u003eAwarded the Spingarn Medal, \n \u003ccorpname\u003eFirst Baptist Church\u003c/corpname\u003e, \n \u003cgeogname\u003eProvidence, Rhode Island\u003c/geogname\u003e, during a\n meeting of the \n \u003ccorpname\u003eNational Association For The Advancement of\n Colored People\u003c/corpname\u003e(NAACP) on 3 May for\n \"distinguished achievement in literature\"; edits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Golden Treasury of Magazine Verse\u003c/title\u003e\u003c/bibref\u003e; awarded an honorary A. M. (Masters) degree\n from \n \u003ccorpname\u003eAtlanta University\u003c/corpname\u003efor his poetry\n and a Litt.D. from \n \u003ccorpname\u003eTalladega College\u003c/corpname\u003e; writes\n introduction to \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Heart of A Woman And Other Poems\u003c/title\u003e\u003c/bibref\u003eby \n \u003cpersname\u003eGeorgia D. Johnson\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1919\u003c/date\u003e\n \u003cevent\u003ePublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Story of The Great War\u003c/title\u003e\u003c/bibref\u003e; edits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eVictory! Celebrated By Thirty-eight American\n Poets\u003c/title\u003e\u003c/bibref\u003e; literary criticism published in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Crisis\u003c/title\u003e\u003c/bibref\u003e, \"Some Contemporary Poets of The Negro Race\";\n edits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Book of Modern British Verse\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1920\u003c/date\u003e\n \u003cevent\u003ePublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eOur Essayists And Critics Today\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1921\u003c/date\u003e\n \u003cevent\u003eWrites introduction to \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Beggars' Vision\u003c/title\u003e\u003c/bibref\u003eby \n \u003cpersname\u003eBrookes More\u003c/persname\u003e; publishes poetry\n volume, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eA Tale Of A Walled Town And Other\n Verses\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1921-1927\u003c/date\u003e\n \u003cevent\u003eFounds and becomes editor-in-chief of \n \u003ccorpname\u003eB. J. Brimmer Publishing\n Company\u003c/corpname\u003ewith \n \u003cpersname\u003eWinifred Jackson\u003c/persname\u003eas a partner and\n company treasurer; she buys the company in 1925, the\n same year of its bankruptcy(?) (Several documents in the\n collection indicate the company may have remained\n solvent until 1929.)\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1922\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003eedits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eAnthology of Massachusetts Poets\u003c/title\u003e\u003c/bibref\u003e; \n \u003ccorpname\u003eB. J. Brimmer\u003c/corpname\u003epublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eBronze: A Book of Verse\u003c/title\u003e\u003c/bibref\u003eby \n \u003cpersname\u003eGeorgia Douglas Johnson\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1924\u003c/date\u003e\n \u003cevent\u003e\u003ccorpname\u003eB. J. Brimmer\u003c/corpname\u003epublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eConfusion\u003c/title\u003e\u003c/bibref\u003eby \n \u003cpersname\u003eJames Gould Cozzens\u003c/persname\u003e; \n \u003cpersname\u003eWilliam Stanley\n Braithwaite\u003c/persname\u003epublishes \"The New Negro In\n Literature\" in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Crisis\u003c/title\u003e\u003c/bibref\u003e, and, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eGoing Over Tindal, A Novel\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1928\u003c/date\u003e\n \u003cevent\u003eDeath of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n mother; he publishes a book of stories, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eFrost On The Green Leaf\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1931\u003c/date\u003e\n \u003cevent\u003eEdits \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eOur Lady's Choir: A Contemporary Anthology of\n Verses By Catholic Sisters\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1934\u003c/date\u003e\n \u003cevent\u003eLiterary criticism, \"The Novels of Jessie Faust,\"\n published in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eOpportunity\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1934-1935\u003c/date\u003e\n \u003cevent\u003eAppointed Professor of Creative Literature at \n \u003ccorpname\u003eAtlanta University\u003c/corpname\u003e; retires in\n 1945\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1935\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eAlan F. Peter\u003c/persname\u003eof the \n \u003ccorpname\u003ePoetry Digest Association\u003c/corpname\u003eplans a\n 1935 issue of \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eAnthology of Magazine Verse\u003c/title\u003e\u003c/bibref\u003eand offers \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003ethe\n opportunity of providing editorial assistance\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1936\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003ewrites\n introduction to \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eWe Lift Our Voices And Other Poems\u003c/title\u003e\u003c/bibref\u003eby \n \u003cpersname\u003eMae V. Cowdery\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1937\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eSterling Brown\u003c/persname\u003e, in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eNegro Poetry \u0026amp; Drama\u003c/title\u003e\u003c/bibref\u003e, praises \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003eas a\n poetry critic\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1938\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003eserves\n on a program committee for the \n \u003ccorpname\u003eAssociation of Teachers of English in Negro\n Colleges\u003c/corpname\u003e(later \n \u003ccorpname\u003eThe College Language\n Association\u003c/corpname\u003e)\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1939\u003c/date\u003e\n \u003cevent\u003eDeath of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n paternal uncle, \n \u003cpersname\u003eEdward John Braithwaite\u003c/persname\u003e, age 85, in\n September\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1940\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley\n Braithwaite\u003c/persname\u003epublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Years Between 1918-39\u003c/title\u003e\u003c/bibref\u003eand \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003ePoems, New and Selected\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1941-1942\u003c/date\u003e\n \u003cevent\u003e\u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n autobiography, \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003e\"The House Under Acturus\"\u003c/title\u003e\u003c/bibref\u003eis serialized in five installments in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003ePhylon\u003c/title\u003e\u003c/bibref\u003eduring 1942; it tells the story of his life up\n to the publication of his first book of poems in\n 1904\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1942\u003c/date\u003e\n \u003cevent\u003eAn M. A. thesis by \n \u003cpersname\u003eAlma Westine Stone\u003c/persname\u003eof \n \u003ccorpname\u003eAtlanta University\u003c/corpname\u003eexamines \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n career\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1945\u003c/date\u003e\n \u003cevent\u003eRetires from \n \u003ccorpname\u003eAtlanta University\u003c/corpname\u003eand moves to \n \u003cgeogname\u003eHarlem, New York City\u003c/geogname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1947\u003c/date\u003e\n \u003cevent\u003ePublishes an article in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eNegro Digest\u003c/title\u003e\u003c/bibref\u003e, \"Negro America's First Magazine\"\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1948\u003c/date\u003e\n \u003cevent\u003ePublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eSelected Poems\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1950\u003c/date\u003e\n \u003cevent\u003ePublishes \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Bewitched Parsonage: The Story of The\n Brontes\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1956\u003c/date\u003e\n \u003cevent\u003eInterviewed by \n \u003ccorpname\u003eColumbia University's Oral History Research\n Office\u003c/corpname\u003efrom May to June: \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003e\"The Reminiscences of William S.\n Braithwaite\"\u003c/title\u003e\u003c/bibref\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1957\u003c/date\u003e\n \u003cevent\u003eLiterary criticism published in \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003ePhylon\u003c/title\u003e\u003c/bibref\u003e, \"Alain Locke's Relationship To The Negro In\n American Literature\"; death of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n brother Arthur on 24 September\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1958\u003c/date\u003e\n \u003cevent\u003eCo-edits 1958 \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eAnthology of Magazine Verse\u003c/title\u003e\u003c/bibref\u003ewith \n \u003cpersname\u003eMargaret Carpenter\u003c/persname\u003e, a \n \u003cgeogname\u003eNorfolk, Virginia\u003c/geogname\u003e, poet and\n admirer; it includes a selection of poetry from the\n previous anthologies; \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's\n efforts are hampered by his failing eyesight\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1959\u003c/date\u003e\n \u003cevent\u003eAn \n \u003ccorpname\u003eAmerican Poetry Society\u003c/corpname\u003edinner is\n held in \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e's honor\n in \n \u003cgeogname\u003eNew York City\u003c/geogname\u003e; he writes the\n preface to \n \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eA Voice In Ramah: Poems\u003c/title\u003e\u003c/bibref\u003eby \n \u003cpersname\u003eMarion Buchman\u003c/persname\u003e\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003cchronitem\u003e\n \u003cdate era=\"ce\" calendar=\"gregorian\"\u003e1962\u003c/date\u003e\n \u003cevent\u003eDeath of \n \u003cpersname\u003eWilliam Stanley Braithwaite\u003c/persname\u003e, age\n 83, on 8 June in \n \u003cgeogname\u003eNew York City\u003c/geogname\u003e; funeral held on 12\n June\u003c/event\u003e\n \u003c/chronitem\u003e\n \u003c/chronlist\u003e\n "]}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/viu_viu00186_c01_c04"}},{"id":"wvmturhc_repositories_2_resources_5_c06_c11","type":"Item","attributes":{"title":"The C \u0026 W route by Dry River, Franklin, Big Run and Greenbrier to Marlinton, 1881/1907","breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/wvmturhc_repositories_2_resources_5_c06_c11#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"wvmturhc_repositories_2_resources_5_c06_c11","ref_ssm":["wvmturhc_repositories_2_resources_5_c06_c11"],"id":"wvmturhc_repositories_2_resources_5_c06_c11","ead_ssi":"wvmturhc_repositories_2_resources_5","_root_":"wvmturhc_repositories_2_resources_5","_nest_parent_":"wvmturhc_repositories_2_resources_5_c06","parent_ssi":"wvmturhc_repositories_2_resources_5_c06","parent_ssim":["Stephen B. Elkins Papers, 1841/1955","Maps, Plats and Plans, 1891/1907"],"parent_ids_ssim":["wvmturhc_repositories_2_resources_5","wvmturhc_repositories_2_resources_5_c06"],"title_filing_ssi":"The C \u0026 W route by Dry River, Franklin, Big Run and Greenbrier to Marlinton","title_ssm":["The C \u0026 W route by Dry River, Franklin, Big Run and Greenbrier to Marlinton"],"title_tesim":["The C \u0026 W route by Dry River, Franklin, Big Run and Greenbrier to Marlinton"],"normalized_title_ssm":["The C \u0026 W route by Dry River, Franklin, Big Run and Greenbrier to Marlinton, 1881/1907"],"text":["The C \u0026 W route by Dry River, Franklin, Big Run and Greenbrier to Marlinton, 1881/1907","Stephen B. Elkins Papers, 1841/1955","Maps, Plats and Plans, 1891/1907","Case Map case","English."],"parent_unittitles_ssm":["Stephen B. Elkins Papers, 1841/1955","Maps, Plats and Plans, 1891/1907"],"parent_unittitles_tesim":["Stephen B. Elkins Papers, 1841/1955","Maps, Plats and Plans, 1891/1907"],"normalized_date_ssm":["1881/1907"],"unitdate_inclusive_ssm":["undated"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[2],"sort_isi":160,"repository_ssim":["West Virginia and Regional History Center"],"collection_ssim":["Stephen B. Elkins Papers, 1841/1955"],"containers_ssim":["Case Map case"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["No special access restriction applies."],"parent_access_terms_tesm":["Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website."],"language_ssim":["English."],"date_range_isim":[1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907],"_nest_path_":"/components#5/components#10","timestamp":"2026-08-14T23:10:21.954Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"wvmturhc_repositories_2_resources_5","ead_ssi":"wvmturhc_repositories_2_resources_5","_root_":"wvmturhc_repositories_2_resources_5","_nest_parent_":"wvmturhc_repositories_2_resources_5","ead_source_url_ssi":"data/oai/WVU/repositories_2_resources_5.xml","aspace_url_ssi":"https://archives.lib.wvu.edu/ark:/99999/212429","title_ssm":["Stephen B. Elkins Papers"],"title_tesim":["Stephen B. Elkins Papers"],"unitdate_ssm":["1841-1955"],"unitdate_inclusive_ssm":["1841-1955"],"normalized_date_ssm":["1841/1955"],"normalized_title_ssm":["Stephen B. Elkins Papers, 1841/1955"],"text":["Stephen B. Elkins Papers, 1841/1955","A\u0026M 0053","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/2/resources/5","United States -- Politics and government","Elkins (W. Va.)","West Virginia - politics.","West Virginia - Politics and government.","United States Congressmen - West Virginia.","Civil War - veterans - Union.","Politicians -- United States","Politicians","No special access restriction applies.","Stephen Benton Elkins represented West Virginia in the U.S. Senate from 1895 to 1911. He served in the Union Army during the American Civil War, practiced law in the Territory of New Mexico in 1864, and was a member of the Territorial House of Representatives from 1864 to 1865. From 1866 to 1870, Elkins was first the district attorney, then attorney general, and then U.S. district attorney for the Territory. Around 1890, he moved to the town that he founded, Elkins, WV. President Benjamin Harrison appointed him Secretary of War from 1891 to 1893. Elkins died in Washington, D.C., during his third term in the U.S. Senate.","Born in Perry County, Ohio, in 1841, Elkins attended public schools in Westport, Missouri, and graduated in 1860 from the University of Missouri-Columbia, where he studied law. He then became a school teacher in Harrisonville, Missouri. Among his pupils there was Cole Younger—future Confederate guerrilla and outlaw in the James-Younger Gang. According to accounts provided by both men, Younger later rescued Elkins from execution by Confederate guerrillas during the Civil War. More than 30 years later, Elkins was instrumental in securing parole for Younger, who received a life sentence when convicted of bank robbery.","After enlisting in the Union Army, Elkins served as a captain in the Kansas Militia until 1863. In 1864, he began to practice law in Mesilla, New Mexico, after being admitted to the bar in the Territory of New Mexico. He then served in the Territorial House of Representatives from 1864 to 1865. Elkins also was the district attorney (1866–1867), attorney general (1867), and then U.S. district attorney (1867–1870) for the Territory. In 1872, Elkins was elected to Congress as a Republican representative for the Territory of New Mexico, and served in the Forty-third and Forty-fourth Congresses (March 4, 1873–March 3, 1877); he was not a candidate for re-nomination in 1876.","In 1866, Elkins married Sarah Simms Jacobs. She died prior to Elkins' election to Congress, and was survived by two daughters, Elizabeth and Sallie. In 1875, Elkins married Hallie Davis, daughter of Senator Henry Gassaway Davis of West Virginia. Elkins partnered with Davis in developing natural resources industries in West Virginia, and in 1878, Elkins became a West Virginia citizen. Around 1890, Elkins and his family moved to the town that he founded, Elkins, WV. Together with Davis, Elkins formed the West Virginia Central and Pittsburg Railway, which had main lines emanating from Elkins, WV, and he was associated with the Davis Coal and Coke Company, one of the largest coal companies in existence.","After being elected executive chairman of the National Republican Committee in 1884, Elkins gave his first political speech in West Virginia on February 29, 1888, in Wheeling. President Benjamin Harrison appointed Elkins Secretary of War, and he served from December 17, 1891 to March 5, 1893. Elected as a Republican to the U.S. Senate, Elkins served from March 4, 1895, until his death on January 4, 1911. He was chairman of the Committee on the Geological Survey (Fifty-sixth and Fifty-ninth Congresses) and member of the Committee on Interstate Commerce (Fifty-seventh through Sixty-first Congresses). Elkins was interred in Maplewood Cemetery, Elkins, WV.","Sources:","Clarke, Alan R. The West Virginia Central and Pittsburg Railway: a Western Maryland Predecessor. Lynchburg: TLC Publishing, 2003.","\"Elkins, Stephen Benton, (1841 - 1911).\" Biographical Directory of the United States Congress, 1774-present.","Lambert, Oscar Doane. Stephen Benton Elkins: American Foursquare. Pittsburgh: University of Pittsburgh Press, 1955.","Spears, Jae. \"Stephen B. Elkins.\" The West Virginia Encyclopedia.","Reprocessed by Danielle Emerling and Leo Gmeindl, 2016, and Erica Uszak, 2023","The Stephen B. Elkins papers consists of correspondence; scrapbooks and newspaper clippings; financial, legal, and land records; speeches; photographs, maps; personal papers; and research files related to Elkins' political and business careers. Some materials also relate to the development of the New Mexico Territory and its admission as a state.","The Correspondence series contains letters with political and business associates. Correspondents include several presidents, such as Abraham Lincoln, U.S. Grant, James A. Garfield, Grover Cleveland, Benjamin Harrison, William McKinley, Theodore Roosevelt, and William Howard Taft. Governors and other prominent correspondents include Andrew Carnegie, J.G. Blaine, J.N. Camden, H.G. Davis, M. Hanna, W.S. Herndon, C.C. Catron, R.C. Kerens, J.P. Morgan, and Chauncey Depew. Some selected correspondence is available on microfilm.","The Scrapbooks and Newspaper Clippings series consists of 26 volumes of scrapbooks and loose newspaper stories related to Elkins' political and business careers, personal life, and West Virginia politics and campaigns.","The Financial, Legal, and Land Records series contains papers mainly concerning railroads, mining (coal and silver) and lumbering in West Virginia, New Mexico, Texas, and California.","The Speeches series includes printed speeches made by Elkins throughout his life, and several speeches date to his time in the U.S. Senate.","The Photographs series consists of several images of Elkins, West Virginia, and Halliehurst Mansion. Photographs are available online at West Virginia History OnView","The Maps series includes plans for railroads in the eastern United States and property and mine plans in New Mexico.","The Personal Papers series contains some genealogical materials about the Elkins family.","The Senate Papers series contains bills, Congressional Records, and reports.","Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website.","Stephen Benton Elkins (b. 1841) represented West Virginia in the United States Senate as a Republican from 1895-1911. Prior to his Senate service, Elkins served in the Union Army during the Civil War as a captain in the Kansas Militia. He practiced law in the Territory of New Mexico in 1864 and served as a member of the Territorial House of Representatives, 1864-1865. He was the district attorney for the Territory from 1866-1867, and the United States district attorney for the Territory from 1867-1870. Around 1890, he founded and moved to the city of Elkins, WV. President Benjamin Harrison appointed him Secretary of War, 1891-1893. He died during his third Senate term in 1911 in Washington, DC. The Stephen B. Elkins collection includes speeches, maps, reports, photographs and other materials related to his political, business, and family affairs.","West Virginia and Regional History Center / West Virginia University / 1549 University Avenue / P.O. Box 6069 / Morgantown, WV 26506-6069 / Phone: 304-293-3536 / URL: West Virginia \u0026 Regional History Center","West Virginia and Regional History Center","Republican Party (U.S. : 1854- )","Elkins, Stephen B. (Stephen Benton), 1841-1911","Davis, Henry Gassaway, 1823-1916","Materials are mostly in English. Some materials are in Spanish."],"collection_title_tesim":["Stephen B. Elkins Papers, 1841/1955"],"collection_ssim":["Stephen B. Elkins Papers, 1841/1955"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["A\u0026M 0053","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/2/resources/5"],"unitid_tesim":["A\u0026M 0053","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/2/resources/5"],"repository_ssm":["West Virginia and Regional History Center"],"repository_ssim":["West Virginia and Regional History Center"],"geogname_ssm":["United States -- Politics and government","Elkins (W. Va.)"],"geogname_ssim":["United States -- Politics and government","Elkins (W. Va.)"],"places_ssim":["United States -- Politics and government","Elkins (W. Va.)"],"creator_ssm":["Elkins, Stephen B. (Stephen Benton), 1841-1911"],"creator_ssim":["Elkins, Stephen B. (Stephen Benton), 1841-1911"],"creator_persname_ssim":["Elkins, Stephen B. (Stephen Benton), 1841-1911","Davis, Henry Gassaway, 1823-1916"],"creator_corpname_ssim":["West Virginia and Regional History Center","Republican Party (U.S. : 1854- )"],"creators_ssim":["Elkins, Stephen B. (Stephen Benton), 1841-1911","Davis, Henry Gassaway, 1823-1916","West Virginia and Regional History Center","Republican Party (U.S. : 1854- )"],"access_terms_ssm":["Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website."],"acqinfo_ssim":["A\u0026M 53 - Gift of Davis Elkins, 1937. Eleven boxes (approximately 1,220 items) including correspondence, maps, speeches, newspaper clippings, congressional records, and scrapbooks dating from 1874-1912.","A\u0026M 53 - Purchase of Maury Bromsen Associates, 1977. Letter by Stephen B. Elkins to Col. William Lilley, 1868 April 3 (1 item, Box 1, Folder 1)."],"access_subjects_ssim":["West Virginia - politics.","West Virginia - Politics and government.","United States Congressmen - West Virginia.","Civil War - veterans - Union.","Politicians -- United States","Politicians"],"access_subjects_ssm":["West Virginia - politics.","West Virginia - Politics and government.","United States Congressmen - West Virginia.","Civil War - veterans - Union.","Politicians -- United States","Politicians"],"has_online_content_ssim":["false"],"extent_ssm":["9.52 Linear Feet 9 ft. 6 1/4 in. (15 document cases, 5 in.); (8 large flat box cases, 3.5 in.); (2 small flat storage boxes, 3.5 in); (1 large flat storage box, 1.5 in); (1 oversize folder, 1/4 in,); (1 reel of microfilm and 1 partial reel of microfilm shared with A\u0026M 0591, 1.75 in. each)\n\nThis collection shares a microfilm reel with another collection, A\u0026M 0591. The extent of that reel is record in this collection, not A\u0026M 0591."],"extent_tesim":["9.52 Linear Feet 9 ft. 6 1/4 in. (15 document cases, 5 in.); (8 large flat box cases, 3.5 in.); (2 small flat storage boxes, 3.5 in); (1 large flat storage box, 1.5 in); (1 oversize folder, 1/4 in,); (1 reel of microfilm and 1 partial reel of microfilm shared with A\u0026M 0591, 1.75 in. each)\n\nThis collection shares a microfilm reel with another collection, A\u0026M 0591. The extent of that reel is record in this collection, not A\u0026M 0591."],"date_range_isim":[1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955],"accessrestrict_html_tesm":["\u003cp\u003eNo special access restriction applies.\u003c/p\u003e "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["No special access restriction applies."],"bioghist_html_tesm":["\u003cp\u003eStephen Benton Elkins represented West Virginia in the U.S. Senate from 1895 to 1911. He served in the Union Army during the American Civil War, practiced law in the Territory of New Mexico in 1864, and was a member of the Territorial House of Representatives from 1864 to 1865. From 1866 to 1870, Elkins was first the district attorney, then attorney general, and then U.S. district attorney for the Territory. Around 1890, he moved to the town that he founded, Elkins, WV. President Benjamin Harrison appointed him Secretary of War from 1891 to 1893. Elkins died in Washington, D.C., during his third term in the U.S. Senate.\u003c/p\u003e","\u003cp\u003eBorn in Perry County, Ohio, in 1841, Elkins attended public schools in Westport, Missouri, and graduated in 1860 from the University of Missouri-Columbia, where he studied law. He then became a school teacher in Harrisonville, Missouri. Among his pupils there was Cole Younger—future Confederate guerrilla and outlaw in the James-Younger Gang. According to accounts provided by both men, Younger later rescued Elkins from execution by Confederate guerrillas during the Civil War. More than 30 years later, Elkins was instrumental in securing parole for Younger, who received a life sentence when convicted of bank robbery.\u003c/p\u003e","\u003cp\u003eAfter enlisting in the Union Army, Elkins served as a captain in the Kansas Militia until 1863. In 1864, he began to practice law in Mesilla, New Mexico, after being admitted to the bar in the Territory of New Mexico. He then served in the Territorial House of Representatives from 1864 to 1865. Elkins also was the district attorney (1866–1867), attorney general (1867), and then U.S. district attorney (1867–1870) for the Territory. In 1872, Elkins was elected to Congress as a Republican representative for the Territory of New Mexico, and served in the Forty-third and Forty-fourth Congresses (March 4, 1873–March 3, 1877); he was not a candidate for re-nomination in 1876.\u003c/p\u003e","\u003cp\u003eIn 1866, Elkins married Sarah Simms Jacobs. She died prior to Elkins' election to Congress, and was survived by two daughters, Elizabeth and Sallie. In 1875, Elkins married Hallie Davis, daughter of Senator Henry Gassaway Davis of West Virginia. Elkins partnered with Davis in developing natural resources industries in West Virginia, and in 1878, Elkins became a West Virginia citizen. Around 1890, Elkins and his family moved to the town that he founded, Elkins, WV. Together with Davis, Elkins formed the West Virginia Central and Pittsburg Railway, which had main lines emanating from Elkins, WV, and he was associated with the Davis Coal and Coke Company, one of the largest coal companies in existence.\u003c/p\u003e","\u003cp\u003eAfter being elected executive chairman of the National Republican Committee in 1884, Elkins gave his first political speech in West Virginia on February 29, 1888, in Wheeling. President Benjamin Harrison appointed Elkins Secretary of War, and he served from December 17, 1891 to March 5, 1893. Elected as a Republican to the U.S. Senate, Elkins served from March 4, 1895, until his death on January 4, 1911. He was chairman of the Committee on the Geological Survey (Fifty-sixth and Fifty-ninth Congresses) and member of the Committee on Interstate Commerce (Fifty-seventh through Sixty-first Congresses). Elkins was interred in Maplewood Cemetery, Elkins, WV.\u003c/p\u003e","\u003cp\u003eSources:\u003c/p\u003e","\u003cp\u003eClarke, Alan R. The West Virginia Central and Pittsburg Railway: a Western Maryland Predecessor. Lynchburg: TLC Publishing, 2003.\u003c/p\u003e","\u003cp\u003e\"\u003ca href=\"http://bioguide.congress.gov/scripts/biodisplay.pl?index=E000110\" target=\"_blank\"\u003eElkins, Stephen Benton, (1841 - 1911).\u003c/a\u003e\" Biographical Directory of the United States Congress, 1774-present. \u003c/p\u003e","\u003cp\u003eLambert, Oscar Doane. Stephen Benton Elkins: American Foursquare. Pittsburgh: University of Pittsburgh Press, 1955. \u003c/p\u003e","\u003cp\u003eSpears, Jae. \"\u003ca href=\"http://www.wvencyclopedia.org/articles/2199\" target=\"_blank\"\u003eStephen B. Elkins.\u003c/a\u003e\" The West Virginia Encyclopedia. \u003c/p\u003e "],"bioghist_heading_ssm":["Biographical Note"],"bioghist_tesim":["Stephen Benton Elkins represented West Virginia in the U.S. Senate from 1895 to 1911. He served in the Union Army during the American Civil War, practiced law in the Territory of New Mexico in 1864, and was a member of the Territorial House of Representatives from 1864 to 1865. From 1866 to 1870, Elkins was first the district attorney, then attorney general, and then U.S. district attorney for the Territory. Around 1890, he moved to the town that he founded, Elkins, WV. President Benjamin Harrison appointed him Secretary of War from 1891 to 1893. Elkins died in Washington, D.C., during his third term in the U.S. Senate.","Born in Perry County, Ohio, in 1841, Elkins attended public schools in Westport, Missouri, and graduated in 1860 from the University of Missouri-Columbia, where he studied law. He then became a school teacher in Harrisonville, Missouri. Among his pupils there was Cole Younger—future Confederate guerrilla and outlaw in the James-Younger Gang. According to accounts provided by both men, Younger later rescued Elkins from execution by Confederate guerrillas during the Civil War. More than 30 years later, Elkins was instrumental in securing parole for Younger, who received a life sentence when convicted of bank robbery.","After enlisting in the Union Army, Elkins served as a captain in the Kansas Militia until 1863. In 1864, he began to practice law in Mesilla, New Mexico, after being admitted to the bar in the Territory of New Mexico. He then served in the Territorial House of Representatives from 1864 to 1865. Elkins also was the district attorney (1866–1867), attorney general (1867), and then U.S. district attorney (1867–1870) for the Territory. In 1872, Elkins was elected to Congress as a Republican representative for the Territory of New Mexico, and served in the Forty-third and Forty-fourth Congresses (March 4, 1873–March 3, 1877); he was not a candidate for re-nomination in 1876.","In 1866, Elkins married Sarah Simms Jacobs. She died prior to Elkins' election to Congress, and was survived by two daughters, Elizabeth and Sallie. In 1875, Elkins married Hallie Davis, daughter of Senator Henry Gassaway Davis of West Virginia. Elkins partnered with Davis in developing natural resources industries in West Virginia, and in 1878, Elkins became a West Virginia citizen. Around 1890, Elkins and his family moved to the town that he founded, Elkins, WV. Together with Davis, Elkins formed the West Virginia Central and Pittsburg Railway, which had main lines emanating from Elkins, WV, and he was associated with the Davis Coal and Coke Company, one of the largest coal companies in existence.","After being elected executive chairman of the National Republican Committee in 1884, Elkins gave his first political speech in West Virginia on February 29, 1888, in Wheeling. President Benjamin Harrison appointed Elkins Secretary of War, and he served from December 17, 1891 to March 5, 1893. Elected as a Republican to the U.S. Senate, Elkins served from March 4, 1895, until his death on January 4, 1911. He was chairman of the Committee on the Geological Survey (Fifty-sixth and Fifty-ninth Congresses) and member of the Committee on Interstate Commerce (Fifty-seventh through Sixty-first Congresses). Elkins was interred in Maplewood Cemetery, Elkins, WV.","Sources:","Clarke, Alan R. The West Virginia Central and Pittsburg Railway: a Western Maryland Predecessor. Lynchburg: TLC Publishing, 2003.","\"Elkins, Stephen Benton, (1841 - 1911).\" Biographical Directory of the United States Congress, 1774-present.","Lambert, Oscar Doane. Stephen Benton Elkins: American Foursquare. Pittsburgh: University of Pittsburgh Press, 1955.","Spears, Jae. \"Stephen B. Elkins.\" The West Virginia Encyclopedia."],"prefercite_html_tesm":["\u003cp\u003e[Description and date of item], [Box/folder number], Stephen B. Elkins Papers, A\u0026amp;M 0053, West Virginia and Regional History Center, West Virginia University Libraries, Morgantown, West Virginia.\u003c/p\u003e "],"prefercite_tesim":["[Description and date of item], [Box/folder number], Stephen B. Elkins Papers, A\u0026M 0053, West Virginia and Regional History Center, West Virginia University Libraries, Morgantown, West Virginia."],"processinfo_html_tesm":["\u003cp\u003eReprocessed by Danielle Emerling and Leo Gmeindl, 2016, and Erica Uszak, 2023\u003c/p\u003e "],"processinfo_heading_ssm":["Processing Information"],"processinfo_tesim":["Reprocessed by Danielle Emerling and Leo Gmeindl, 2016, and Erica Uszak, 2023"],"scopecontent_html_tesm":["\u003cp\u003eThe Stephen B. Elkins papers consists of correspondence; scrapbooks and newspaper clippings; financial, legal, and land records; speeches; photographs, maps; personal papers; and research files related to Elkins' political and business careers. Some materials also relate to the development of the New Mexico Territory and its admission as a state. \u003c/p\u003e","\u003cp\u003eThe Correspondence series contains letters with political and business associates. Correspondents include several presidents, such as Abraham Lincoln, U.S. Grant, James A. Garfield, Grover Cleveland, Benjamin Harrison, William McKinley, Theodore Roosevelt, and William Howard Taft. Governors and other prominent correspondents include Andrew Carnegie, J.G. Blaine, J.N. Camden, H.G. Davis, M. Hanna, W.S. Herndon, C.C. Catron, R.C. Kerens, J.P. Morgan, and Chauncey Depew. Some selected correspondence is available on microfilm.\u003c/p\u003e","\u003cp\u003eThe Scrapbooks and Newspaper Clippings series consists of 26 volumes of scrapbooks and loose newspaper stories related to Elkins' political and business careers, personal life, and West Virginia politics and campaigns.\u003c/p\u003e","\u003cp\u003eThe Financial, Legal, and Land Records series contains papers mainly concerning railroads, mining (coal and silver) and lumbering in West Virginia, New Mexico, Texas, and California. \u003c/p\u003e","\u003cp\u003eThe Speeches series includes printed speeches made by Elkins throughout his life, and several speeches date to his time in the U.S. Senate. \u003c/p\u003e","\u003cp\u003eThe Photographs series consists of several images of Elkins, West Virginia, and Halliehurst Mansion. Photographs are available online at \u003ca href=\"https://wvhistoryonview.org/?utf8=%E2%9C%93\u0026amp;search_field=collection_number\u0026amp;q=%22A%26M+53%22\" target=\"_blank\"\u003eWest Virginia History OnView\u003c/a\u003e\u003c/p\u003e","\u003cp\u003e\nThe Maps series includes plans for railroads in the eastern United States and property and mine plans in New Mexico. \u003c/p\u003e","\u003cp\u003eThe Personal Papers series contains some genealogical materials about the Elkins family. \u003c/p\u003e","\u003cp\u003eThe Senate Papers series contains bills, Congressional Records, and reports. \u003c/p\u003e "],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["The Stephen B. Elkins papers consists of correspondence; scrapbooks and newspaper clippings; financial, legal, and land records; speeches; photographs, maps; personal papers; and research files related to Elkins' political and business careers. Some materials also relate to the development of the New Mexico Territory and its admission as a state.","The Correspondence series contains letters with political and business associates. Correspondents include several presidents, such as Abraham Lincoln, U.S. Grant, James A. Garfield, Grover Cleveland, Benjamin Harrison, William McKinley, Theodore Roosevelt, and William Howard Taft. Governors and other prominent correspondents include Andrew Carnegie, J.G. Blaine, J.N. Camden, H.G. Davis, M. Hanna, W.S. Herndon, C.C. Catron, R.C. Kerens, J.P. Morgan, and Chauncey Depew. Some selected correspondence is available on microfilm.","The Scrapbooks and Newspaper Clippings series consists of 26 volumes of scrapbooks and loose newspaper stories related to Elkins' political and business careers, personal life, and West Virginia politics and campaigns.","The Financial, Legal, and Land Records series contains papers mainly concerning railroads, mining (coal and silver) and lumbering in West Virginia, New Mexico, Texas, and California.","The Speeches series includes printed speeches made by Elkins throughout his life, and several speeches date to his time in the U.S. Senate.","The Photographs series consists of several images of Elkins, West Virginia, and Halliehurst Mansion. Photographs are available online at West Virginia History OnView","The Maps series includes plans for railroads in the eastern United States and property and mine plans in New Mexico.","The Personal Papers series contains some genealogical materials about the Elkins family.","The Senate Papers series contains bills, Congressional Records, and reports."],"userestrict_html_tesm":["\u003cp\u003ePermission to publish or reproduce is required from the copyright holder. For more information, please see the \u003ca href=\"https://wvrhc.lib.wvu.edu/visit/permissions-and-copyright\" target=\"_blank\"\u003ePermissions and Copyright page\u003c/a\u003e on the West Virginia and Regional History Center website.\u003c/p\u003e "],"userestrict_heading_ssm":["Conditions Governing Use"],"userestrict_tesim":["Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website."],"abstract_html_tesm":["\u003cabstract id=\"aspace_bf1c58490b879c32ab052dff8db58638\"\u003eStephen Benton Elkins (b. 1841) represented West Virginia in the United States Senate as a Republican from 1895-1911. Prior to his Senate service, Elkins served in the Union Army during the Civil War as a captain in the Kansas Militia. He practiced law in the Territory of New Mexico in 1864 and served as a member of the Territorial House of Representatives, 1864-1865. He was the district attorney for the Territory from 1866-1867, and the United States district attorney for the Territory from 1867-1870. Around 1890, he founded and moved to the city of Elkins, WV. President Benjamin Harrison appointed him Secretary of War, 1891-1893. He died during his third Senate term in 1911 in Washington, DC. The Stephen B. Elkins collection includes speeches, maps, reports, photographs and other materials related to his political, business, and family affairs.\u003c/abstract\u003e\n "],"abstract_tesim":["Stephen Benton Elkins (b. 1841) represented West Virginia in the United States Senate as a Republican from 1895-1911. Prior to his Senate service, Elkins served in the Union Army during the Civil War as a captain in the Kansas Militia. He practiced law in the Territory of New Mexico in 1864 and served as a member of the Territorial House of Representatives, 1864-1865. He was the district attorney for the Territory from 1866-1867, and the United States district attorney for the Territory from 1867-1870. Around 1890, he founded and moved to the city of Elkins, WV. President Benjamin Harrison appointed him Secretary of War, 1891-1893. He died during his third Senate term in 1911 in Washington, DC. The Stephen B. Elkins collection includes speeches, maps, reports, photographs and other materials related to his political, business, and family affairs."],"physloc_html_tesm":["\u003cphysloc id=\"aspace_f25c2e04db0ca7fc126b9f4b7f29236a\"\u003eWest Virginia and Regional History Center / West Virginia University / 1549 University Avenue / P.O. Box 6069 / Morgantown, WV 26506-6069 / Phone: 304-293-3536 / URL: \u003ca href=\"https://wvrhc.lib.wvu.edu/\"\u003eWest Virginia \u0026amp; Regional History Center\u003c/a\u003e\u003c/physloc\u003e\n "],"physloc_tesim":["West Virginia and Regional History Center / West Virginia University / 1549 University Avenue / P.O. Box 6069 / Morgantown, WV 26506-6069 / Phone: 304-293-3536 / URL: West Virginia \u0026 Regional History Center"],"corpname_ssim":["West Virginia and Regional History Center","Republican Party (U.S. : 1854- )"],"names_coll_ssim":["Republican Party (U.S. : 1854- )","Davis, Henry Gassaway, 1823-1916"],"persname_ssim":["Elkins, Stephen B. (Stephen Benton), 1841-1911","Davis, Henry Gassaway, 1823-1916"],"names_ssim":["West Virginia and Regional History Center","Republican Party (U.S. : 1854- )","Elkins, Stephen B. (Stephen Benton), 1841-1911","Davis, Henry Gassaway, 1823-1916"],"language_ssim":["Materials are mostly in English. Some materials are in Spanish."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":175,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T23:10:21.954Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/wvmturhc_repositories_2_resources_5_c06_c11"}},{"id":"wvmturhc_repositories_2_resources_3726_c02_c10","type":"Item","attributes":{"title":"\"The Double Embryo of the Florida Alligator\", 1906","breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/wvmturhc_repositories_2_resources_3726_c02_c10#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"wvmturhc_repositories_2_resources_3726_c02_c10","ref_ssm":["wvmturhc_repositories_2_resources_3726_c02_c10"],"id":"wvmturhc_repositories_2_resources_3726_c02_c10","ead_ssi":"wvmturhc_repositories_2_resources_3726","_root_":"wvmturhc_repositories_2_resources_3726","_nest_parent_":"wvmturhc_repositories_2_resources_3726_c02","parent_ssi":"wvmturhc_repositories_2_resources_3726_c02","parent_ssim":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970","Clippings -- Articles Authored by Reese (usually only a few paragraphs long; listed by order in folder), 1900/1937"],"parent_ids_ssim":["wvmturhc_repositories_2_resources_3726","wvmturhc_repositories_2_resources_3726_c02"],"title_filing_ssi":"\"The Double Embryo of the Florida Alligator\"","title_ssm":["\"The Double Embryo of the Florida Alligator\""],"title_tesim":["\"The Double Embryo of the Florida Alligator\""],"normalized_title_ssm":["\"The Double Embryo of the Florida Alligator\", 1906"],"text":["\"The Double Embryo of the Florida Alligator\", 1906","Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970","Clippings -- Articles Authored by Reese (usually only a few paragraphs long; listed by order in folder), 1900/1937","Box 1","Folder 2"],"parent_unittitles_ssm":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970","Clippings -- Articles Authored by Reese (usually only a few paragraphs long; listed by order in folder), 1900/1937"],"parent_unittitles_tesim":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970","Clippings -- Articles Authored by Reese (usually only a few paragraphs long; listed by order in folder), 1900/1937"],"normalized_date_ssm":["1906"],"unitdate_inclusive_ssm":["1906 January 8"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[2],"sort_isi":12,"repository_ssim":["West Virginia and Regional History Center"],"collection_ssim":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970"],"containers_ssim":["Box 1","Folder 2"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["No special access restriction applies."],"parent_access_terms_tesm":["Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website."],"date_range_isim":[1906],"_nest_path_":"/components#1/components#9","timestamp":"2026-08-14T23:09:24.326Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"wvmturhc_repositories_2_resources_3726","ead_ssi":"wvmturhc_repositories_2_resources_3726","_root_":"wvmturhc_repositories_2_resources_3726","_nest_parent_":"wvmturhc_repositories_2_resources_3726","ead_source_url_ssi":"data/oai/WVU/repositories_2_resources_3726.xml","aspace_url_ssi":"https://archives.lib.wvu.edu/ark:/99999/197557","title_ssm":["Albert Moore Reese, Zoology Professor, Miscellaneous Items"],"title_tesim":["Albert Moore Reese, Zoology Professor, Miscellaneous Items"],"unitdate_ssm":["1900-1970"],"unitdate_inclusive_ssm":["1900-1970"],"normalized_date_ssm":["1900/1970"],"normalized_title_ssm":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970"],"text":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970","A\u0026M 5024","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/2/resources/3726","No special access restriction applies.","Papers of Albert Moore Reese, Sr, longtime zoology professor at West Virginia University. This collection includes WVU memorabilia, books and reprints by Albert Moore Reese, and photos of Reese and Reese's spelunking trips, and clippings of articles by Reese and others.","Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website.","West Virginia and Regional History Center / West Virginia University / 1549 University Avenue / P.O. Box 6069 / Morgantown, WV 26506-6069 / Phone: 304-293-3536 / URL: West Virginia \u0026 Regional History Center","West Virginia and Regional History Center","Reese, A. M. (Albert Moore), 1872-1965","English"],"collection_title_tesim":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970"],"collection_ssim":["Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/1970"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["A\u0026M 5024","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/2/resources/3726"],"unitid_tesim":["A\u0026M 5024","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/2/resources/3726"],"repository_ssm":["West Virginia and Regional History Center"],"repository_ssim":["West Virginia and Regional History Center"],"creator_ssm":["Reese, A. M. (Albert Moore), 1872-1965"],"creator_ssim":["Reese, A. M. (Albert Moore), 1872-1965"],"creator_persname_ssim":["Reese, A. M. (Albert Moore), 1872-1965"],"creator_corpname_ssim":["West Virginia and Regional History Center"],"creators_ssim":["Reese, A. M. (Albert Moore), 1872-1965","West Virginia and Regional History Center"],"access_terms_ssm":["Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website."],"has_online_content_ssim":["false"],"extent_ssm":["0.4 Linear Feet Summary: 5 in. (1 document case)"],"extent_tesim":["0.4 Linear Feet Summary: 5 in. (1 document case)"],"date_range_isim":[1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970],"accessrestrict_html_tesm":["\u003cp\u003eNo special access restriction applies.\u003c/p\u003e "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["No special access restriction applies."],"prefercite_html_tesm":["\u003cp\u003e[Description and date of item], [Box/folder number], Albert Moore Reese, Zoology Professor, Miscellaneous Items, A\u0026amp;M 5024, West Virginia and Regional History Center, West Virginia University Libraries, Morgantown, West Virginia.\u003c/p\u003e "],"prefercite_tesim":["[Description and date of item], [Box/folder number], Albert Moore Reese, Zoology Professor, Miscellaneous Items, A\u0026M 5024, West Virginia and Regional History Center, West Virginia University Libraries, Morgantown, West Virginia."],"scopecontent_html_tesm":["\u003cp\u003ePapers of Albert Moore Reese, Sr, longtime zoology professor at West Virginia University. This collection includes WVU memorabilia, books and reprints by Albert Moore Reese, and photos of Reese and Reese's spelunking trips, and clippings of articles by Reese and others.\u003c/p\u003e "],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Papers of Albert Moore Reese, Sr, longtime zoology professor at West Virginia University. This collection includes WVU memorabilia, books and reprints by Albert Moore Reese, and photos of Reese and Reese's spelunking trips, and clippings of articles by Reese and others."],"userestrict_html_tesm":["\u003cp\u003ePermission to publish or reproduce is required from the copyright holder. For more information, please see the \u003ca href=\"https://wvrhc.lib.wvu.edu/visit/permissions-and-copyright\" target=\"_blank\"\u003ePermissions and Copyright page\u003c/a\u003e on the West Virginia and Regional History Center website.\u003c/p\u003e "],"userestrict_heading_ssm":["Conditions Governing Use"],"userestrict_tesim":["Permission to publish or reproduce is required from the copyright holder. For more information, please see the Permissions and Copyright page on the West Virginia and Regional History Center website."],"physloc_html_tesm":["\u003cphysloc id=\"aspace_475c6beddf907c59124a80c45246b5e1\"\u003eWest Virginia and Regional History Center / West Virginia University / 1549 University Avenue / P.O. Box 6069 / Morgantown, WV 26506-6069 / Phone: 304-293-3536 / URL: \u003ca href=\"https://wvrhc.lib.wvu.edu/\"\u003eWest Virginia \u0026amp; Regional History Center\u003c/a\u003e\u003c/physloc\u003e\n "],"physloc_tesim":["West Virginia and Regional History Center / West Virginia University / 1549 University Avenue / P.O. Box 6069 / Morgantown, WV 26506-6069 / Phone: 304-293-3536 / URL: West Virginia \u0026 Regional History Center"],"corpname_ssim":["West Virginia and Regional History Center"],"persname_ssim":["Reese, A. M. (Albert Moore), 1872-1965"],"names_coll_ssim":["Reese, A. M. (Albert Moore), 1872-1965"],"names_ssim":["West Virginia and Regional History Center","Reese, A. M. (Albert Moore), 1872-1965"],"language_ssim":["English"],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":64,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T23:09:24.326Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/wvmturhc_repositories_2_resources_3726_c02_c10"}},{"id":"viu_repositories_7_resources_1710_c02_c258_c02","type":"Item","attributes":{"title":"The Establishment of a Settlement for Lepers, 1900/1930","abstract_or_scope":{"id":"https://search.arvasarchive.org/catalog/viu_repositories_7_resources_1710_c02_c258_c02#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eThe unknown author describes the settlement for lepers that Carter established in Panama.\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/viu_repositories_7_resources_1710_c02_c258_c02#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_7_resources_1710_c02_c258_c02","ref_ssm":["viu_repositories_7_resources_1710_c02_c258_c02"],"id":"viu_repositories_7_resources_1710_c02_c258_c02","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710_c02_c258","parent_ssi":"viu_repositories_7_resources_1710_c02_c258","parent_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932","Miscellaneous notes and reports, 1880/1940"],"parent_ids_ssim":["viu_repositories_7_resources_1710","viu_repositories_7_resources_1710_c02","viu_repositories_7_resources_1710_c02_c258"],"title_filing_ssi":"The Establishment of a Settlement for Lepers","title_ssm":["The Establishment of a Settlement for Lepers"],"title_tesim":["The Establishment of a Settlement for Lepers"],"normalized_title_ssm":["The Establishment of a Settlement for Lepers, 1900/1930"],"text":["The Establishment of a Settlement for Lepers, 1900/1930","Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932","Miscellaneous notes and reports, 1880/1940","box 13","folder 25","Diseases","Public health","Social history","reports","English","The unknown author describes the settlement for lepers that Carter established in Panama."],"parent_unittitles_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932","Miscellaneous notes and reports, 1880/1940"],"parent_unittitles_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932","Miscellaneous notes and reports, 1880/1940"],"normalized_date_ssm":["1900/1930"],"unitdate_inclusive_ssm":["circa 1900-1930"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[3],"sort_isi":1877,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"extent_ssm":["3 pages"],"extent_tesim":["3 pages"],"containers_ssim":["box 13","folder 25"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"parent_access_terms_tesm":["Copyright restrictions may apply for some materials in the collection."],"access_subjects_ssim":["Diseases","Public health","Social history","reports"],"access_subjects_ssm":["Diseases","Public health","Social history","reports"],"language_ssim":["English"],"date_range_isim":[1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930],"scopecontent_html_tesm":["\u003cp\u003eThe unknown author describes the settlement for lepers that Carter established in Panama.\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["The unknown author describes the settlement for lepers that Carter established in Panama."],"_nest_path_":"/components#1/components#257/components#1","timestamp":"2026-08-14T22:54:59.526Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_7_resources_1710","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","ead_source_url_ssi":"data/oai/UVA/repositories_7_resources_1710.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/202324","title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection"],"title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection"],"unitdate_ssm":["circa 1800-circa 1998","bulk 1863-1974"],"unitdate_inclusive_ssm":["circa 1800-circa 1998"],"unitdate_bulk_ssim":["bulk 1863-1974"],"normalized_date_ssm":["1800/1998, bulk 1863/1974"],"normalized_title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"text":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","MS.1","Archival Resource Key","/repositories/7/resources/1710","Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever","There are no restrictions on user access to any of the materials in the collection except where noted in the container list.","The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n II. Henry Rose Carter\n III. Walter Reed\n IV. Philip Showalter Hench\n V. Maps\n VI. Alphabetical files\n VII. Truby-Kean-Hench\n VIII. Miscellany\n IX. Photographs\n X. Photographic negatives\n XI. Reprints\n XII. Houston Academy of Medicine/Texas Medical Center additions\n XIII. Reed family additions\n XIV. P. Kahler Hench additions\n XV. Laura Wood\n XVI. Edward Hook additions","The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n When does a mosquito develop the ability to transmit the disease?\n Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [16] Please see note [7].\n [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.","Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n Series II. Henry Rose Carter\n Series III. Walter Reed\n Series IV. Philip Showalter Hench\n Series V. Maps\n Series VI. Alphabetical files\n Series VII. Truby-Kean-Hench\n Series VIII. Miscellany\n Series IX. Photographs\n Series X. Negatives\n Series XI. Reprints\n Series XIII. Reed family additions\n Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.","Processed by:\n Historical Collections Staff","Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n correspondence of other Lazear family members (e.g. Jesse's parents);\n genealogical summaries and tables relating to the Lazear family;\n legal documents (e.g. wills, certificates, deeds);\n military records relating to Jesse;\n certificates, reports, and other materials documenting Jesse's educational background and achievements;\n obituaries;\n copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n newspaper articles;\n a microscope and sets of microscope slides owned by Jesse;\n and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n journal articles concerning the study and eradication of yellow fever and malaria;\n research notes written by Henry Rose Carter;\n and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n condolence letters for Henry Rose Carter's family after Henry's death;\n and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n articles announcing the death of Walter Reed;\n and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n scientific reports and publications related to the study and eradication of yellow fever and malaria;\n and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n autobiographical accounts of the experiment's participants and their families;\n notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n scripts for radio programs relating to the yellow fever experiments;\n notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n Cuba;\n sites associated with the yellow fever experiments;\n and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n other correspondence;\n newspaper and magazine clippings;\n unpublished manuscripts;\n biographical and autobiographical accounts;\n transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n articles and clippings related to the yellow fever experiments;\n a short biography of Lemuel S. Reed;\n and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n diplomas and certificates for Walter Reed and Jesse W. Lazear;\n copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n correspondence of Philip Showalter Hench from circa 1940 to 1966;\n articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n photographs relating to Cuba and the yellow fever experiments;\n notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n the U.S.S.Maineand the Spanish-American War;\n aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n scenes of daily life in Cuba generally from between 1898 and 1960;\n the 1952 dedication of the Camp Lazear National Monument in Cuba;\n the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n still scenes from the movies,Yellow JackandJezebel;\n other events and works of art commemorating the work of the participants in the yellow fever experiments;\n documents and maps that Philip Showalter Hench copied for his research;\n and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n biographical accounts of various people who had an association with the yellow fever experiments;\n the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n scientific and medical research related to yellow fever and malaria;\n and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n newspaper clippings and articles relating to the yellow fever experiments;\n a chemistry notebook that was owned by Walter Reed;\n correspondence of and works by Philip Showalter Hench;\n an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n correspondence between Philip Showalter Hench and the experiment participants;\n correspondence between Philip Showalter Hench and families of the experiment participants;\n press clippings relating to the experiments and the experiment participants;\n oral history interviews conducted by Philip Showalter Hench;\n scientific articles related to the study of yellow fever;\n photographs of Havana, Camp Columbia, and Camp Lazear;\n genealogical tables and summaries for the family of Jesse W. Lazear;\n autobiographical accounts written by experiment participants;\n unpublished manuscripts;\n artifacts (e.g. a wooden board) from Camp Lazear;\n Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n a journal article by George Sternberg;\n and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.","Copyright restrictions may apply for some materials in the collection.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.","Claude Moore Health Sciences Library","Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"collection_title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"unitid_tesim":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_corpname_ssim":["Claude Moore Health Sciences Library"],"creators_ssim":["Claude Moore Health Sciences Library"],"access_terms_ssm":["Copyright restrictions may apply for some materials in the collection."],"acqinfo_ssim":["Materials from the following series were donated to the University of Virginia's Alderman Library in the fall of 1966 and the summer of 1970 by Philip Showalter Hench's widow, Mary Kahler Hench, with the approval of his estate:","Series I. Jesse W. Lazear\n Series II. Henry Rose Carter\n Series III. Walter Reed\n Series IV. Philip Showalter Hench\n Series V. Maps\n Series VI. Alphabetical files\n Series VII. Truby-Kean-Hench\n Series VIII. Miscellany\n Series IX. Photographs\n Series X. Negatives\n Series XI. Reprints","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were donated to the HAM/TMC by Philip Showalter Hench as a small part of a larger collection of materials.","Materials from Series XIII. Reed family additions were donated by various individuals to Alderman Library between 1947 and 1972. Box 139, Folder 1 contains a list that describes each of these donations in detail.","Materials from Series XIV. P. Kahler Hench were donated to the Claude Moore Health Sciences Library by Philip Showalter Hench's son, P. Kahler Hench, in 1988 and 1989.","Materials from Series XV. Laura Wood were most likely donated to Alderman Library between 1972 and 1982.","Materials from Series XVI. Edward Hook additions were donated to the Claude Moore Health Sciences Library as a part of the Papers of Dr. Edward Watson Hook, Jr."],"access_subjects_ssim":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"access_subjects_ssm":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"has_online_content_ssim":["false"],"extent_ssm":["67 Linear Feet 154 boxes"],"extent_tesim":["67 Linear Feet 154 boxes"],"date_range_isim":[1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998],"accessrestrict_html_tesm":["\u003cp\u003eThere are no restrictions on user access to any of the materials in the collection except where noted in the container list.\u003c/p\u003e "],"accessrestrict_heading_ssm":["Access"],"accessrestrict_tesim":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"arrangement_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eI. Jesse W. Lazear\u003c/item\u003e\n \u003citem\u003eII. Henry Rose Carter\u003c/item\u003e\n \u003citem\u003eIII. Walter Reed\u003c/item\u003e\n \u003citem\u003eIV. Philip Showalter Hench\u003c/item\u003e\n \u003citem\u003eV. Maps\u003c/item\u003e\n \u003citem\u003eVI. Alphabetical files\u003c/item\u003e\n \u003citem\u003eVII. Truby-Kean-Hench\u003c/item\u003e\n \u003citem\u003eVIII. Miscellany\u003c/item\u003e\n \u003citem\u003eIX. Photographs\u003c/item\u003e\n \u003citem\u003eX. Photographic negatives\u003c/item\u003e\n \u003citem\u003eXI. Reprints\u003c/item\u003e\n \u003citem\u003eXII. Houston Academy of Medicine/Texas Medical Center additions\u003c/item\u003e\n \u003citem\u003eXIII. Reed family additions\u003c/item\u003e\n \u003citem\u003eXIV. P. Kahler Hench additions\u003c/item\u003e\n \u003citem\u003eXV. Laura Wood\u003c/item\u003e\n \u003citem\u003eXVI. Edward Hook additions\u003c/item\u003e\n \u003c/list\u003e\n "],"arrangement_heading_ssm":["Organization of the Collection"],"arrangement_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n II. Henry Rose Carter\n III. Walter Reed\n IV. Philip Showalter Hench\n V. Maps\n VI. Alphabetical files\n VII. Truby-Kean-Hench\n VIII. Miscellany\n IX. Photographs\n X. Photographic negatives\n XI. Reprints\n XII. Houston Academy of Medicine/Texas Medical Center additions\n XIII. Reed family additions\n XIV. P. Kahler Hench additions\n XV. Laura Wood\n XVI. Edward Hook additions"],"bioghist_heading_ssm":["Historical Information for the U.S. Army Yellow Fever Commission","Biographical Information for Walter Reed","Biographical Information for Jesse W. Lazear","Biographical Information for Henry Rose Carter","Biographical Information for Jefferson Randolph Kean","Biographical Information for Philip Showalter Hench"],"bioghist_tesim":["The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n When does a mosquito develop the ability to transmit the disease?\n Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [16] Please see note [7].\n [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001."],"custodhist_html_tesm":["\u003cp\u003eMaterials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eSeries I. Jesse W. Lazear\u003c/item\u003e\n \u003citem\u003eSeries II. Henry Rose Carter\u003c/item\u003e\n \u003citem\u003eSeries III. Walter Reed\u003c/item\u003e\n \u003citem\u003eSeries IV. Philip Showalter Hench\u003c/item\u003e\n \u003citem\u003eSeries V. Maps\u003c/item\u003e\n \u003citem\u003eSeries VI. Alphabetical files\u003c/item\u003e\n \u003citem\u003eSeries VII. Truby-Kean-Hench\u003c/item\u003e\n \u003citem\u003eSeries VIII. Miscellany\u003c/item\u003e\n \u003citem\u003eSeries IX. Photographs\u003c/item\u003e\n \u003citem\u003eSeries X. Negatives\u003c/item\u003e\n \u003citem\u003eSeries XI. Reprints\u003c/item\u003e\n \u003citem\u003eSeries XIII. Reed family additions\u003c/item\u003e\n \u003citem\u003eSeries XV. Laura Wood\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eMaterials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.\u003c/p\u003e","\u003cp\u003e Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.\u003c/p\u003e "],"custodhist_heading_ssm":["Custodial History"],"custodhist_tesim":["Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n Series II. Henry Rose Carter\n Series III. Walter Reed\n Series IV. Philip Showalter Hench\n Series V. Maps\n Series VI. Alphabetical files\n Series VII. Truby-Kean-Hench\n Series VIII. Miscellany\n Series IX. Photographs\n Series X. Negatives\n Series XI. Reprints\n Series XIII. Reed family additions\n Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s."],"odd_html_tesm":["\u003clist type=\"deflist\"\u003e\n \u003cdefitem\u003e\n \u003clabel\u003eProcessed by:\u003c/label\u003e\n \u003citem\u003eHistorical Collections Staff\u003c/item\u003e\n \u003c/defitem\u003e\n \u003c/list\u003e\n "],"odd_heading_ssm":["General"],"odd_tesim":["Processed by:\n Historical Collections Staff"],"prefercite_html_tesm":["\u003cp\u003ePhilip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia\u003c/p\u003e "],"prefercite_tesim":["Philip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia"],"processinfo_html_tesm":["\u003cp\u003eMary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.\u003c/p\u003e","\u003cp\u003e Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.\u003c/p\u003e","\u003cp\u003e In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.\u003c/p\u003e","\u003cp\u003e Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.\u003c/p\u003e","\u003cp\u003e Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.\u003c/p\u003e","\u003cp\u003e In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.\u003c/p\u003e","\u003cp\u003e In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.\u003c/p\u003e","\u003cp\u003e In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.\u003c/p\u003e "],"processinfo_heading_ssm":["Processing History"],"processinfo_tesim":["Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog."],"scopecontent_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","\u003cp\u003e In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ethe diaries documenting the travels of Jesse and Mabel's mothers in Europe;\u003c/item\u003e\n \u003citem\u003ecorrespondence of other Lazear family members (e.g. Jesse's parents);\u003c/item\u003e\n \u003citem\u003egenealogical summaries and tables relating to the Lazear family;\u003c/item\u003e\n \u003citem\u003elegal documents (e.g. wills, certificates, deeds);\u003c/item\u003e\n \u003citem\u003emilitary records relating to Jesse;\u003c/item\u003e\n \u003citem\u003ecertificates, reports, and other materials documenting Jesse's educational background and achievements;\u003c/item\u003e\n \u003citem\u003eobituaries;\u003c/item\u003e\n \u003citem\u003ecopies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\u003c/item\u003e\n \u003citem\u003enewspaper articles;\u003c/item\u003e\n \u003citem\u003ea microscope and sets of microscope slides owned by Jesse;\u003c/item\u003e\n \u003citem\u003eand a medical chart that shows the progression of the yellow fever infection that killed Jesse.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\u003c/item\u003e\n \u003citem\u003escientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\u003c/item\u003e\n \u003citem\u003ejournal articles concerning the study and eradication of yellow fever and malaria;\u003c/item\u003e\n \u003citem\u003eresearch notes written by Henry Rose Carter;\u003c/item\u003e\n \u003citem\u003eand photographs of Henry Rose Carter at work and with professional colleagues.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.\u003c/p\u003e","\u003cp\u003e In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecopies of obituaries for Henry Rose Carter;\u003c/item\u003e\n \u003citem\u003econdolence letters for Henry Rose Carter's family after Henry's death;\u003c/item\u003e\n \u003citem\u003eand the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\u003c/item\u003e\n \u003citem\u003emilitary records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\u003c/item\u003e\n \u003citem\u003eWalter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\u003c/item\u003e\n \u003citem\u003emedical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\u003c/item\u003e\n \u003citem\u003earticles announcing the death of Walter Reed;\u003c/item\u003e\n \u003citem\u003eand the shoulder boards from Walter Reed's U.S. Army uniform.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003earticles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\u003c/item\u003e\n \u003citem\u003ebiographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n \u003citem\u003erecords relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\u003c/item\u003e\n \u003citem\u003ecopies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n \u003citem\u003eand letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003e.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eFinally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eitems (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\u003c/item\u003e\n \u003citem\u003ematerials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\u003c/item\u003e\n \u003citem\u003escientific reports and publications related to the study and eradication of yellow fever and malaria;\u003c/item\u003e\n \u003citem\u003eand newspaper articles describing various outbreaks of yellow fever epidemics.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eHench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\u003c/item\u003e\n \u003citem\u003eautobiographical accounts of the experiment's participants and their families;\u003c/item\u003e\n \u003citem\u003enotes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\u003c/item\u003e\n \u003citem\u003ecorrespondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\u003c/item\u003e\n \u003citem\u003ecorrespondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\u003c/item\u003e\n \u003citem\u003enewspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\u003c/item\u003e\n \u003citem\u003edrafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\u003c/item\u003e\n \u003citem\u003emeeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\u003c/item\u003e\n \u003citem\u003escripts for radio programs relating to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003enotes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\u003c/item\u003e\n \u003citem\u003eand the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eHavana and its environs;\u003c/item\u003e\n \u003citem\u003eCuba;\u003c/item\u003e\n \u003citem\u003esites associated with the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003eand military installations in the United States.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.\u003c/p\u003e","\u003cp\u003e Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and the individuals;\u003c/item\u003e\n \u003citem\u003eother correspondence;\u003c/item\u003e\n \u003citem\u003enewspaper and magazine clippings;\u003c/item\u003e\n \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n \u003citem\u003ebiographical and autobiographical accounts;\u003c/item\u003e\n \u003citem\u003etranscripts of oral history interviews that were conducted by Philip Showalter Hench;\u003c/item\u003e\n \u003citem\u003eand copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.\u003c/p\u003e","\u003cp\u003e Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\u003c/item\u003e\n \u003citem\u003ePhilip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\u003c/item\u003e\n \u003citem\u003ea scrapbook and other materials that relate to Truby's book,\u003ctitle render=\"italic\"\u003eMemoir of Walter Reed: the Yellow Fever Episode\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003eand Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials relating to Kean and Truby, Series VII. also includes the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003enotes from Philip Showalter Hench's research of the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ethe recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\u003c/item\u003e\n \u003citem\u003earticles and clippings related to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ea short biography of Lemuel S. Reed;\u003c/item\u003e\n \u003citem\u003eand a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003einformed consent agreements for volunteers in the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ediplomas and certificates for Walter Reed and Jesse W. Lazear;\u003c/item\u003e\n \u003citem\u003ecopies and sketches of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003eartifacts, including a wooden board from Camp Lazear and a U.S. flag;\u003c/item\u003e\n \u003citem\u003ecopies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003emanuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ecorrespondence of Philip Showalter Hench from circa 1940 to 1966;\u003c/item\u003e\n \u003citem\u003earticles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n \u003citem\u003ecorrespondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n \u003citem\u003eitems that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n \u003citem\u003ephotographs relating to Cuba and the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003enotes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ephysicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\u003c/item\u003e\n \u003citem\u003efamily members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\u003c/item\u003e\n \u003citem\u003eCamp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\u003c/item\u003e\n \u003citem\u003ethe U.S.S.\u003cemph render=\"italic\"\u003eMaine\u003c/emph\u003eand the Spanish-American War;\u003c/item\u003e\n \u003citem\u003eaerial views of Havana, Cuba and its environs from the 1940s and 1950s;\u003c/item\u003e\n \u003citem\u003escenes of daily life in Cuba generally from between 1898 and 1960;\u003c/item\u003e\n \u003citem\u003ethe 1952 dedication of the Camp Lazear National Monument in Cuba;\u003c/item\u003e\n \u003citem\u003ethe creation and unveiling of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003estill scenes from the movies,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003eand\u003ctitle render=\"italic\"\u003eJezebel\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003eother events and works of art commemorating the work of the participants in the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003edocuments and maps that Philip Showalter Hench copied for his research;\u003c/item\u003e\n \u003citem\u003eand Philip Showalter Hench and his family.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries IX. also includes a watercolor that was painted by Emilie Lawrence Reed.\u003c/p\u003e","\u003cp\u003e Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.\u003c/p\u003e","\u003cp\u003e The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.\u003c/p\u003e","\u003cp\u003e Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ethe results of the U.S. Army Yellow Fever Commission's work in Cuba;\u003c/item\u003e\n \u003citem\u003ebiographical accounts of various people who had an association with the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ethe research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\u003c/item\u003e\n \u003citem\u003escientific and medical research related to yellow fever and malaria;\u003c/item\u003e\n \u003citem\u003eand events honoring the work of those involved with the yellow fever experiments.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\u003c/item\u003e\n \u003citem\u003enewspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ephotographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\u003c/item\u003e\n \u003citem\u003eand journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.\u003c/p\u003e","\u003cp\u003e In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ea flag that was flown over Camp Lazear;\u003c/item\u003e\n \u003citem\u003enewspaper clippings and articles relating to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ea chemistry notebook that was owned by Walter Reed;\u003c/item\u003e\n \u003citem\u003ecorrespondence of and works by Philip Showalter Hench;\u003c/item\u003e\n \u003citem\u003ean inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\u003c/item\u003e\n \u003citem\u003eand materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ethe correspondence of experiment participants;\u003c/item\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and the experiment participants;\u003c/item\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and families of the experiment participants;\u003c/item\u003e\n \u003citem\u003epress clippings relating to the experiments and the experiment participants;\u003c/item\u003e\n \u003citem\u003eoral history interviews conducted by Philip Showalter Hench;\u003c/item\u003e\n \u003citem\u003escientific articles related to the study of yellow fever;\u003c/item\u003e\n \u003citem\u003ephotographs of Havana, Camp Columbia, and Camp Lazear;\u003c/item\u003e\n \u003citem\u003egenealogical tables and summaries for the family of Jesse W. Lazear;\u003c/item\u003e\n \u003citem\u003eautobiographical accounts written by experiment participants;\u003c/item\u003e\n \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n \u003citem\u003eartifacts (e.g. a wooden board) from Camp Lazear;\u003c/item\u003e\n \u003citem\u003ePhilip Showalter Hench's research notes.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.\u003c/p\u003e","\u003cp\u003e Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ephotocopies of two letters written by Walter Reed;\u003c/item\u003e\n \u003citem\u003ea journal article by George Sternberg;\u003c/item\u003e\n \u003citem\u003eand a short work that Laura Wood wrote about Walter Reed entitled,\u003ctitle render=\"italic\"\u003eWalter Reed and yellow Fever\u003c/title\u003e.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eItems in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.\u003c/p\u003e","\u003cp\u003e Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ephotographs of Walter Reed and others related to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ecopies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\u003c/item\u003e\n \u003citem\u003eand exhibition materials.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eItems in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.\u003c/p\u003e "],"scopecontent_heading_ssm":["Scope and Content Information"],"scopecontent_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n correspondence of other Lazear family members (e.g. Jesse's parents);\n genealogical summaries and tables relating to the Lazear family;\n legal documents (e.g. wills, certificates, deeds);\n military records relating to Jesse;\n certificates, reports, and other materials documenting Jesse's educational background and achievements;\n obituaries;\n copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n newspaper articles;\n a microscope and sets of microscope slides owned by Jesse;\n and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n journal articles concerning the study and eradication of yellow fever and malaria;\n research notes written by Henry Rose Carter;\n and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n condolence letters for Henry Rose Carter's family after Henry's death;\n and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n articles announcing the death of Walter Reed;\n and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n scientific reports and publications related to the study and eradication of yellow fever and malaria;\n and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n autobiographical accounts of the experiment's participants and their families;\n notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n scripts for radio programs relating to the yellow fever experiments;\n notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n Cuba;\n sites associated with the yellow fever experiments;\n and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n other correspondence;\n newspaper and magazine clippings;\n unpublished manuscripts;\n biographical and autobiographical accounts;\n transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n articles and clippings related to the yellow fever experiments;\n a short biography of Lemuel S. Reed;\n and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n diplomas and certificates for Walter Reed and Jesse W. Lazear;\n copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n correspondence of Philip Showalter Hench from circa 1940 to 1966;\n articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n photographs relating to Cuba and the yellow fever experiments;\n notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n the U.S.S.Maineand the Spanish-American War;\n aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n scenes of daily life in Cuba generally from between 1898 and 1960;\n the 1952 dedication of the Camp Lazear National Monument in Cuba;\n the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n still scenes from the movies,Yellow JackandJezebel;\n other events and works of art commemorating the work of the participants in the yellow fever experiments;\n documents and maps that Philip Showalter Hench copied for his research;\n and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n biographical accounts of various people who had an association with the yellow fever experiments;\n the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n scientific and medical research related to yellow fever and malaria;\n and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n newspaper clippings and articles relating to the yellow fever experiments;\n a chemistry notebook that was owned by Walter Reed;\n correspondence of and works by Philip Showalter Hench;\n an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n correspondence between Philip Showalter Hench and the experiment participants;\n correspondence between Philip Showalter Hench and families of the experiment participants;\n press clippings relating to the experiments and the experiment participants;\n oral history interviews conducted by Philip Showalter Hench;\n scientific articles related to the study of yellow fever;\n photographs of Havana, Camp Columbia, and Camp Lazear;\n genealogical tables and summaries for the family of Jesse W. Lazear;\n autobiographical accounts written by experiment participants;\n unpublished manuscripts;\n artifacts (e.g. a wooden board) from Camp Lazear;\n Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n a journal article by George Sternberg;\n and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901."],"userestrict_html_tesm":["\u003cp\u003eCopyright restrictions may apply for some materials in the collection.\u003c/p\u003e "],"userestrict_heading_ssm":["Copyright Status"],"userestrict_tesim":["Copyright restrictions may apply for some materials in the collection."],"abstract_html_tesm":["\u003cabstract id=\"aspace_98fe81a152b4be0b7388b1814ffaf4bd\"\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.\u003c/abstract\u003e\n "],"abstract_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission."],"corpname_ssim":["Claude Moore Health Sciences Library"],"names_ssim":["Claude Moore Health Sciences Library"],"language_ssim":["Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":10452,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:54:59.526Z","bioghist_html_tesm":["\u003cp\u003eThe U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.\u003c/p\u003e","\u003cp\u003e When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.\u003c/p\u003e","\u003cp\u003e The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.\u003c/p\u003e","\u003cp\u003e In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.\u003c/p\u003e","\u003cp\u003e Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued that\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003ewas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.\u003c/p\u003e","\u003cp\u003e Despite Wasdin and Geddings' insistence, the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003etheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of the\u003cemph render=\"italic\"\u003eicteroides\u003c/emph\u003eproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003equestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.\u003c/p\u003e","\u003cp\u003e Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identified\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003ein tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.\u003c/p\u003e","\u003cp\u003e What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.\u003c/p\u003e","\u003cp\u003e \"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.\u003c/p\u003e","\u003cp\u003e Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.\u003c/p\u003e","\u003cp\u003e On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.\u003c/p\u003e","\u003cp\u003e These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.\u003c/p\u003e","\u003cp\u003e Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.\u003c/p\u003e","\u003cp\u003e Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.\u003c/p\u003e","\u003cp\u003e The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the variety\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003e(later called\u003cemph render=\"italic\"\u003eStegomyia fasciata\u003c/emph\u003e, and later still\u003cemph render=\"italic\"\u003eAedes aegypti\u003c/emph\u003e) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eHow could a building become infected?\u003c/item\u003e\n \u003citem\u003eWhen does a mosquito develop the ability to transmit the disease?\u003c/item\u003e\n \u003citem\u003eOver what length of time can a mosquito retain this capacity to infect?\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eThe second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.\u003c/p\u003e","\u003cp\u003e The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.\u003c/p\u003e","\u003cp\u003e The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.\u003c/p\u003e","\u003cp\u003e Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.\u003cemph render=\"italic\"\u003eCulex pungens\u003c/emph\u003efailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated that\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas the only species capable of transmitting yellow fever. [11]\u003c/p\u003e","\u003cp\u003e A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle the\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003equestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow any\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003e, conclusively invalidating Sanarelli's claim.\u003c/p\u003e","\u003cp\u003e Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.\u003c/p\u003e","\u003cp\u003e Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:\u003c/p\u003e","\u003cp\u003e \"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"\u003c/p\u003e","\u003cp\u003e \"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]\u003c/p\u003e","\u003cp\u003e The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.\u003c/p\u003e","\u003cp\u003e That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.\u003c/p\u003e","\u003cp\u003e The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.\u003c/p\u003e","\u003cp\u003e For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.\u003c/p\u003e","\u003cp\u003e Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper as\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e, published immediately in the\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e. [16]\u003c/p\u003e","\u003cp\u003e Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Walter Reed and James Carroll,\u003ctitle render=\"doublequote\"\u003eBacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical News\u003c/title\u003e(29 April 1899), reprinted in: United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever, A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 55.\u003c/item\u003e\n \u003citem\u003e[2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\u003c/item\u003e\n \u003citem\u003e[3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 94.\u003c/item\u003e\n \u003citem\u003e[4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\u003c/item\u003e\n \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association\u003c/title\u003eIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/item\u003e\n \u003citem\u003e[6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\u003c/item\u003e\n \u003citem\u003e[7] Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\u003c/item\u003e\n \u003citem\u003e[8] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n \u003citem\u003e[9] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n \u003citem\u003e[10] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 101.\u003c/item\u003e\n \u003citem\u003e[11]\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas reclassified shortly after the experiments as\u003cemph render=\"italic\"\u003eStegomyia\u003c/emph\u003eand later became\u003cemph render=\"italic\"\u003eAedes aegypti.\u003c/emph\u003e\u003c/item\u003e\n \u003citem\u003e[12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\u003c/item\u003e\n \u003citem\u003e[13] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 97.\u003c/item\u003e\n \u003citem\u003e[14] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 98.\u003c/item\u003e\n \u003citem\u003e[15] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n \u003citem\u003e[16] Please see note [7].\u003c/item\u003e\n \u003citem\u003e[17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eExperimental Yellow Fever\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eII (6 July 1901) 1: 15-23.\u003c/item\u003e\n \u003citem\u003e[18] Walter Reed, James Carroll,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever (A Supplemental Note)\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eIII (22 February 1902) 8: 301-305.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eWalter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.\u003c/p\u003e","\u003cp\u003e Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.\u003c/p\u003e","\u003cp\u003e At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.\u003c/p\u003e","\u003cp\u003e Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.\u003c/p\u003e","\u003cp\u003e Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.\u003c/p\u003e","\u003cp\u003e Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.\u003c/p\u003e","\u003cp\u003e Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in the\u003ctitle render=\"italic\"\u003eArmy Register\u003c/title\u003e, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\u003c/item\u003e\n \u003citem\u003e[2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,\u003ctitle render=\"italic\"\u003eWalter Reed and Yellow Fever\u003c/title\u003e(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eJesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.\u003c/p\u003e","\u003cp\u003e \"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.\u003c/p\u003e","\u003cp\u003e Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]\u003c/p\u003e","\u003cp\u003e These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on the\u003cemph render=\"italic\"\u003eAnopheles\u003c/emph\u003emosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.\u003c/p\u003e","\u003cp\u003e The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship of\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.\u003c/p\u003e","\u003cp\u003e The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.\u003c/p\u003e","\u003cp\u003e Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.\u003c/p\u003e","\u003cp\u003e [1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\u003c/item\u003e\n \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n \u003citem\u003e[4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\u003c/item\u003e\n \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note,\u003c/title\u003e \u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/title\u003e\u003c/item\u003e\n \u003citem\u003e[6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\u003c/item\u003e\n \u003citem\u003e[7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\u003c/item\u003e\n \u003citem\u003e[8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eHenry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.\u003c/p\u003e","\u003cp\u003e Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.\u003c/p\u003e","\u003cp\u003e Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]\u003c/p\u003e","\u003cp\u003e Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in the\u003ctitle render=\"italic\"\u003eNew Orleans Medical and Surgical Journal\u003c/title\u003e, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]\u003c/p\u003e","\u003cp\u003e Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003e[5]\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] T. H. D. Griffitts,\u003ctitle render=\"doublequote\"\u003eHenry Rose Carter: The Scientist and the Man\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eSouthern Medical Journal\u003c/title\u003e32 (August 1939) 8: 842.\u003c/item\u003e\n \u003citem\u003e[2] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n \u003citem\u003e[4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\u003c/item\u003e\n \u003citem\u003e[5] Carter, Henry Rose.\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003eBaltimore: The Williams and Wilkins Company, 1931.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eJefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.\u003c/p\u003e","\u003cp\u003e \"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.\u003c/p\u003e","\u003cp\u003e Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.\u003c/p\u003e","\u003cp\u003e In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,\u003ctitle render=\"italic\"\u003eThe Military Surgeon\u003c/title\u003e, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\u003c/item\u003e\n \u003citem\u003e[2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\u003c/item\u003e\n \u003citem\u003e[3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003ePhilip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.\u003c/p\u003e","\u003cp\u003e Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.\u003c/p\u003e","\u003cp\u003e The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.\u003c/p\u003e","\u003cp\u003e For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.\u003c/p\u003e","\u003cp\u003e In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\u003c/item\u003e\n \u003citem\u003e[2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.\u003c/item\u003e\n \u003c/list\u003e\n "]}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/viu_repositories_7_resources_1710_c02_c258_c02"}},{"id":"vircu_repositories_5_resources_96_c07_c17_c10","type":"Item","attributes":{"title":"The Housewife- Harper's Monthly-August, 1906","breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/vircu_repositories_5_resources_96_c07_c17_c10#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"vircu_repositories_5_resources_96_c07_c17_c10","ref_ssm":["vircu_repositories_5_resources_96_c07_c17_c10"],"id":"vircu_repositories_5_resources_96_c07_c17_c10","ead_ssi":"vircu_repositories_5_resources_96","_root_":"vircu_repositories_5_resources_96","_nest_parent_":"vircu_repositories_5_resources_96_c07_c17","parent_ssi":"vircu_repositories_5_resources_96_c07_c17","parent_ssim":["James Branch Cabell collection, 1860/1971","Series VII--Periodicals (essays, reviews and fiction by Cabell)","Bound Periodicals"],"parent_ids_ssim":["vircu_repositories_5_resources_96","vircu_repositories_5_resources_96_c07","vircu_repositories_5_resources_96_c07_c17"],"title_filing_ssi":"The Housewife- Harper's Monthly-August","title_ssm":["The Housewife- Harper's Monthly-August"],"title_tesim":["The Housewife- Harper's Monthly-August"],"normalized_title_ssm":["The Housewife- Harper's Monthly-August, 1906"],"text":["The Housewife- Harper's Monthly-August, 1906","James Branch Cabell collection, 1860/1971","Series VII--Periodicals (essays, reviews and fiction by Cabell)","Bound Periodicals"],"parent_unittitles_ssm":["James Branch Cabell collection, 1860/1971","Series VII--Periodicals (essays, reviews and fiction by Cabell)","Bound Periodicals"],"parent_unittitles_tesim":["James Branch Cabell collection, 1860/1971","Series VII--Periodicals (essays, reviews and fiction by Cabell)","Bound Periodicals"],"normalized_date_ssm":["1906"],"unitdate_inclusive_ssm":["1906"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[3],"sort_isi":383,"repository_ssim":["Virginia Commonwealth University, Cabell Library"],"collection_ssim":["James Branch Cabell collection, 1860/1971"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["The collection is open to research."],"parent_access_terms_tesm":["There are no restrictions."],"date_range_isim":[1906],"_nest_path_":"/components#6/components#16/components#9","timestamp":"2026-08-14T22:40:16.668Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"vircu_repositories_5_resources_96","ead_ssi":"vircu_repositories_5_resources_96","_root_":"vircu_repositories_5_resources_96","_nest_parent_":"vircu_repositories_5_resources_96","ead_source_url_ssi":"data/oai/VCU/repositories_5_resources_96.xml","aspace_url_ssi":"http://ead.lib.virginia.edu/vivaxtf/view?docId=vcu-cab/vircu00065.xml","title_filing_ssi":"Cabell, James Branch, collection","title_ssm":["James Branch Cabell collection"],"title_tesim":["James Branch Cabell collection"],"unitdate_ssm":["1860-1971"],"unitdate_inclusive_ssm":["1860-1971"],"normalized_date_ssm":["1860/1971"],"normalized_title_ssm":["James Branch Cabell collection, 1860/1971"],"text":["James Branch Cabell collection, 1860/1971","M 214","/repositories/5/resources/96","Authors, American -- Virginia -- Richmond","Authors, American -- Manuscripts -- Virginia -- Richmond","The collection is open to research.","Collection is arranged alphabetically. Series I -- Correspondence (1860s-1960s); Series II -- Manuscripts; Series III -- Ephemera, printed material, illustrations, newspaper clippings, etc.; Series IV -- Cabell Society (1963- 1971); Series V -- Between Friends; Series VI -- Criticisms of Cabell's work; Series VII -- Periodicals (essays, reviews and fiction by Cabell); Series VIII -- Dramatic and musical interpretations of Cabell's work; Series IX -- Scrapbooks, notebooks and oversized items.","The collection includes materials removed from books in Cabell's personal library. When Jean Maurice Duke cataloged the book collection he assigned a number (written in pencil) to each item indicating what volume the materials was taken from. Please see James Branch Cabell's Library: A Catalogue by Duke, for reference.","Richmond author James Branch Cabell (1879-1958) is best known for his controversial book, Jurgen (1919), a fantasy set in Cabell's mythical medieval world of Poictesme (pronounced Pwa-tem). The New York Society for the Suppression of Vice contended the book was obscene. A trial over its content brought the reclusive writer national fame. Throughout the 1920s, Cabell's literary peers, including H.L. Mencken and Sinclair Lewis, praised his works.","Cabell was born April 14, 1879, at 101 E. Franklin St., the present site of the Richmond Public Library. His father was Robert Gamble Cabell, II (1847-1922), a physician; his mother Anne Harris (1859-1915), daughter of Col. and Mrs. James R. Branch. Cabell's great grandfather was William H. Cabell, governor of Virginia from 1805-1808. Cabell had two brothers, Robert Gamble Cabell, III (1881-1968) and John Lottier Cabell (1883-1946). His parents divorced in 1907.","After attending the College of William and Mary (1893-1898), where he taught courses in French and Greek while an undergraduate, Cabell worked briefly at the Richmond Times as a copyholder. In 1899 he moved to New York City and worked for the New York Herald as a social reporter. He returned to Richmond in 1901 and worked several months on the staff of the Richmond News. During the next ten years, he performed genealogical research and wrote numerous short stories and articles, which he contributed to national magazines such as Harper's Monthly Magazine and the Saturday Evening Post.","In 1911, Cabell worked as a bookkeeper for his uncle James R. Branch's coal mine in West Virginia. Returning to Richmond in 1913, he married Rebecca Priscilla Bradley Shepherd (1874-1949), a widow with five children by her previous marriage. They had one son, Ballard Hartwell Cabell (1915-1980).","Although he had written for newspapers, Cabell's first published nonfiction work was \"The Comedies of William Congreve,\" which appeared in the April 1901 edition of International. He published his first book, The Eagle's Shadow, in the autumn of 1904 after it appeared serially in the Saturday Evening Post during that summer. His work was slow to draw critical attention. However, by 1918 he had published ten major works and began attracting critical admirers. In an article for the New York Evening Mail, H.L. Mencken described Cabell as \"the only first-rate literary craftsman that the whole South can show.\" Cabell's stature and fame as an author increased with the 1919 publication of Jurgen.","On January 14, 1920, the New York State Society for the Prevention of Vice charged Cabell's publishing editor, Guy Holt, with violating the anti-obscenity provisions of the New York State Penal Code by publishing Jurgen. The controversy over the charges and the attempt at censorship brought Cabell much notoriety. Writers defended the artistry of Jurgen and Cabell's right to publish it.","The obscenity trial over Jurgen began October 16, 1922, and ended three days later with an acquittal of all charges. The presiding judge, Charles C. Nott, stated in his decision \"...the most that can be said against the book is that certain passages therein may be considered suggestive in a veiled and subtle way of immorality, but such suggestions are delicately conveyed\" and that because of Cabell's writing style \"...it is doubtful if the book could be read or understood at all by more than a very limited number of readers.\"","Throughout the 1920s, he continued to publish in the style of Jurgen, a combination of satire, symbolism, and fantasy, set in a mythical medieval French province of Poictesme. The name was a compound of two provinces located in the South of France, Poitiers and Angouleme. Cabell blended an assortment of myths and legends laced with puns, anagrams, and allegories in these books. These works eventually became part of an eighteen-volume collection entitled The Biography of the Life of Manuel; the last volume was published in 1930.","Cabell had become well regarded by prominent writers of the period and maintained an extensive correspondence with a wide circle of literary artists and friends, including Mencken, Joseph Hergesheimer, Burton Rascoe, Theodore Dreiser, Sinclair Lewis, F. Scott Fitzgerald, Carl Van Vechten, and fellow Richmonder and close friend Ellen Glasgow (1873-1945). He had known Glasgow since his days at William and Mary. He served as editor of the Virginia War History Commission (1919-1926) and later joined Dreiser, Eugene O'Neil, and others on the editorial board of the American Spectator (1932-1935). In 1937, Cabell was elected to the American Academy of Arts and Sciences.","While the controversy over Jurgen ensured Cabell an audience throughout most of the 1920s, interest in his books dropped sharply in the New Deal era of the 1930s and continued to decline. In 1932, in an attempt to break away from his past, he began publishing under the name Branch Cabell. During the next three decades, he wrote and published nearly twenty more books. They were grouped in a series of trilogies. He returned as James Branch Cabell in 1947 with the publication of Let Me Lie. It was the first installment of his fifth and last trilogy, consisting mainly of semi-autobiographical essays filled with remembrances of Virginia.","Cabell continued to live and work in Richmond, residing at 3201 Monument Avenue. By 1935 he and his family began spending most of their winter months in St. Augustine, Florida, due to Cabell's reoccurring bouts of pneumonia. During their stay in Florida in 1949, his wife died of heart failure. In 1950, he married Margaret Waller Freeman (1893-1983), whom he had known for many years. Cabell suffered a cerebral hemorrhage in 1958, and on May 5, he died at his home in Richmond.","Cabell's writings, published in various magazines, newspapers, and anthologies, included numerous short stories, poetry, essays, book reviews, and one play. He authored more than 52 volumes of work, including three devoted to genealogy. Cabell is recognized as one of the first contemporary writers from the South. Like his friend, Ellen Glasgow, Cabell was not afraid to satirize what he saw as the South's contradictions. Others, noting Cabell's unique blending of classic myths and legends with his imagination, consider him a pioneer of fantasy writing.","Soon after the establishment of Virginia Commonwealth University (VCU) in 1968, created by the merger of the Medical College of Virginia (MCV) and Richmond Professional Institute (RPI), the University began construction for a new library on the Monroe Park Campus. RPI had already planned for a new library and approached Margaret Cabell about naming it for her husband. VCU approved the name, and in 1970, the James Branch Cabell Library opened its doors.","The collection contains James Branch Cabell's personal papers along with materials by other creators related to Cabell. Cabell corresponded with a number of American and British authors such as H.L. Mencken, Ellen Glasgow, Sinclair Lewis, and Theodore Dreiser, as well as with family, friends, editors and publishers. Other materials of note include his manuscripts with Cabells handwritten edits, his notebooks containing information about his published works along with poems and other writings, and the materials found inside the books of his personal library. The materials provide insight into Cabell's writings and personal interests based upon the content he placed within the books of his collection.","Series I contains correspondence between Cabell and his contemporaries in the literary world, family and friends.","Series II includes various Cabell manuscripts as story ideas, notes, early drafts, school work, essays and poems.","Series III is composed primarily of materials found placed inside Cabell's books and includes ephemera, pamphlets, newspaper clippings, etc.","Series IV are materials from the Cabell Society and contain correspondence between its founders and correspondence between Cabell and Nelson Bond and Cabell and Frederick Eddy.","Series V has materials related to the book Between Friends: Letters of James Branch Cabell and Others, edited by Padraic Colum and Margaret Freeman Cabell.","Series VI consists of various criticisms of Cabell's writings, most of which were collected by Jean Maurice Duke while writing James Branch Cabell: A Reference Guide.","Series VII includes works by Cabell printed in various periodicals. He often published essays, short stories, and other fiction in periodicals before later revising them into book form. The majority of this series is made up of bound volumes. Each volume is named for a published Cabell book and contains the full periodical where the content originally appeared before he developed it into a book.","Series VIII contains plays, poems, and other works inspired by Cabell's work.","Series IX includes scrapbooks and notebooks containing clippings, letters, notes, poems, and other writings by Cabell.","There are no restrictions.","VCU James Branch Cabell Library","Cabell, James Branch, 1879-1958","Flora, Joseph M.","English"],"collection_title_tesim":["James Branch Cabell collection, 1860/1971"],"collection_ssim":["James Branch Cabell collection, 1860/1971"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["M 214","/repositories/5/resources/96"],"unitid_tesim":["M 214","/repositories/5/resources/96"],"repository_ssm":["Virginia Commonwealth University, Cabell Library"],"repository_ssim":["Virginia Commonwealth University, Cabell Library"],"creator_ssm":["Cabell, James Branch, 1879-1958","Flora, Joseph M."],"creator_ssim":["Cabell, James Branch, 1879-1958","Flora, Joseph M."],"creator_persname_ssim":["Cabell, James Branch, 1879-1958","Flora, Joseph M."],"creator_corpname_ssim":["VCU James Branch Cabell Library"],"creators_ssim":["Cabell, James Branch, 1879-1958","Flora, Joseph M.","VCU James Branch Cabell Library"],"access_terms_ssm":["There are no restrictions."],"acqinfo_ssim":["Donated by Margaret Freeman Cabell in 1976."],"access_subjects_ssim":["Authors, American -- Virginia -- Richmond","Authors, American -- Manuscripts -- Virginia -- Richmond"],"access_subjects_ssm":["Authors, American -- Virginia -- Richmond","Authors, American -- Manuscripts -- Virginia -- Richmond"],"has_online_content_ssim":["false"],"extent_ssm":["10 Linear Feet Also includes 3000 volume library"],"extent_tesim":["10 Linear Feet Also includes 3000 volume library"],"date_range_isim":[1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971],"accessrestrict_html_tesm":["\u003cp\u003eThe collection is open to research.\u003c/p\u003e "],"accessrestrict_heading_ssm":["Access Restrictions"],"accessrestrict_tesim":["The collection is open to research."],"arrangement_html_tesm":["\u003cp\u003eCollection is arranged alphabetically. Series I -- Correspondence (1860s-1960s); Series II -- Manuscripts; Series III -- Ephemera, printed material, illustrations, newspaper clippings, etc.; Series IV -- Cabell Society (1963- 1971); Series V -- Between Friends; Series VI -- Criticisms of Cabell's work; Series VII -- Periodicals (essays, reviews and fiction by Cabell); Series VIII -- Dramatic and musical interpretations of Cabell's work; Series IX -- Scrapbooks, notebooks and oversized items.\u003c/p\u003e","\u003cp\u003eThe collection includes materials removed from books in Cabell's personal library. When Jean Maurice Duke cataloged the book collection he assigned a number (written in pencil) to each item indicating what volume the materials was taken from. Please see James Branch Cabell's Library: A Catalogue by Duke, for reference.\u003c/p\u003e "],"arrangement_heading_ssm":["Arrangement"],"arrangement_tesim":["Collection is arranged alphabetically. Series I -- Correspondence (1860s-1960s); Series II -- Manuscripts; Series III -- Ephemera, printed material, illustrations, newspaper clippings, etc.; Series IV -- Cabell Society (1963- 1971); Series V -- Between Friends; Series VI -- Criticisms of Cabell's work; Series VII -- Periodicals (essays, reviews and fiction by Cabell); Series VIII -- Dramatic and musical interpretations of Cabell's work; Series IX -- Scrapbooks, notebooks and oversized items.","The collection includes materials removed from books in Cabell's personal library. When Jean Maurice Duke cataloged the book collection he assigned a number (written in pencil) to each item indicating what volume the materials was taken from. Please see James Branch Cabell's Library: A Catalogue by Duke, for reference."],"bioghist_html_tesm":["\u003cp\u003eRichmond author James Branch Cabell (1879-1958) is best known for his controversial book, \u003ctitle\u003eJurgen\u003c/title\u003e (1919), a fantasy set in Cabell's mythical medieval world of Poictesme (pronounced Pwa-tem). The New York Society for the Suppression of Vice contended the book was obscene. A trial over its content brought the reclusive writer national fame. Throughout the 1920s, Cabell's literary peers, including H.L. Mencken and Sinclair Lewis, praised his works.\u003c/p\u003e","\u003cp\u003eCabell was born April 14, 1879, at 101 E. Franklin St., the present site of the Richmond Public Library. His father was Robert Gamble Cabell, II (1847-1922), a physician; his mother Anne Harris (1859-1915), daughter of Col. and Mrs. James R. Branch. Cabell's great grandfather was William H. Cabell, governor of Virginia from 1805-1808. Cabell had two brothers, Robert Gamble Cabell, III (1881-1968) and John Lottier Cabell (1883-1946). His parents divorced in 1907.\u003c/p\u003e","\u003cp\u003eAfter attending the College of William and Mary (1893-1898), where he taught courses in French and Greek while an undergraduate, Cabell worked briefly at the \u003ctitle\u003eRichmond Times\u003c/title\u003e as a copyholder. In 1899 he moved to New York City and worked for the \u003ctitle\u003eNew York Herald\u003c/title\u003e as a social reporter. He returned to Richmond in 1901 and worked several months on the staff of the \u003ctitle\u003eRichmond News\u003c/title\u003e. During the next ten years, he performed genealogical research and wrote numerous short stories and articles, which he contributed to national magazines such as \u003ctitle\u003eHarper's Monthly Magazine\u003c/title\u003e and the \u003ctitle\u003eSaturday Evening Post\u003c/title\u003e.\u003c/p\u003e","\u003cp\u003eIn 1911, Cabell worked as a bookkeeper for his uncle James R. Branch's coal mine in West Virginia. Returning to Richmond in 1913, he married Rebecca Priscilla Bradley Shepherd (1874-1949), a widow with five children by her previous marriage. They had one son, Ballard Hartwell Cabell (1915-1980).\u003c/p\u003e","\u003cp\u003eAlthough he had written for newspapers, Cabell's first published nonfiction work was \"The Comedies of William Congreve,\" which appeared in the April 1901 edition of \u003ctitle\u003eInternational\u003c/title\u003e. He published his first book, \u003ctitle\u003eThe Eagle's Shadow\u003c/title\u003e, in the autumn of 1904 after it appeared serially in the \u003ctitle\u003eSaturday Evening Post\u003c/title\u003e during that summer. His work was slow to draw critical attention. However, by 1918 he had published ten major works and began attracting critical admirers. In an article for the \u003ctitle\u003eNew York Evening Mail\u003c/title\u003e, H.L. Mencken described Cabell as \"the only first-rate literary craftsman that the whole South can show.\" Cabell's stature and fame as an author increased with the 1919 publication of Jurgen.\u003c/p\u003e","\u003cp\u003eOn January 14, 1920, the New York State Society for the Prevention of Vice charged Cabell's publishing editor, Guy Holt, with violating the anti-obscenity provisions of the New York State Penal Code by publishing \u003ctitle\u003eJurgen\u003c/title\u003e. The controversy over the charges and the attempt at censorship brought Cabell much notoriety. Writers defended the artistry of Jurgen and Cabell's right to publish it.\u003c/p\u003e","\u003cp\u003eThe obscenity trial over Jurgen began October 16, 1922, and ended three days later with an acquittal of all charges. The presiding judge, Charles C. Nott, stated in his decision \"...the most that can be said against the book is that certain passages therein may be considered suggestive in a veiled and subtle way of immorality, but such suggestions are delicately conveyed\" and that because of Cabell's writing style \"...it is doubtful if the book could be read or understood at all by more than a very limited number of readers.\"\u003c/p\u003e","\u003cp\u003eThroughout the 1920s, he continued to publish in the style of \u003ctitle\u003eJurgen\u003c/title\u003e, a combination of satire, symbolism, and fantasy, set in a mythical medieval French province of Poictesme. The name was a compound of two provinces located in the South of France, Poitiers and Angouleme. Cabell blended an assortment of myths and legends laced with puns, anagrams, and allegories in these books. These works eventually became part of an eighteen-volume collection entitled \u003ctitle\u003eThe Biography of the Life of Manuel\u003c/title\u003e; the last volume was published in 1930.\u003c/p\u003e","\u003cp\u003eCabell had become well regarded by prominent writers of the period and maintained an extensive correspondence with a wide circle of literary artists and friends, including Mencken, Joseph Hergesheimer, Burton Rascoe, Theodore Dreiser, Sinclair Lewis, F. Scott Fitzgerald, Carl Van Vechten, and fellow Richmonder and close friend Ellen Glasgow (1873-1945). He had known Glasgow since his days at William and Mary. He served as editor of the Virginia War History Commission (1919-1926) and later joined Dreiser, Eugene O'Neil, and others on the editorial board of the \u003ctitle\u003eAmerican Spectator\u003c/title\u003e (1932-1935). In 1937, Cabell was elected to the American Academy of Arts and Sciences.\u003c/p\u003e","\u003cp\u003eWhile the controversy over \u003ctitle\u003eJurgen\u003c/title\u003e ensured Cabell an audience throughout most of the 1920s, interest in his books dropped sharply in the New Deal era of the 1930s and continued to decline. In 1932, in an attempt to break away from his past, he began publishing under the name Branch Cabell. During the next three decades, he wrote and published nearly twenty more books. They were grouped in a series of trilogies. He returned as James Branch Cabell in 1947 with the publication of \u003ctitle\u003eLet Me Lie\u003c/title\u003e. It was the first installment of his fifth and last trilogy, consisting mainly of semi-autobiographical essays filled with remembrances of Virginia.\u003c/p\u003e","\u003cp\u003eCabell continued to live and work in Richmond, residing at 3201 Monument Avenue. By 1935 he and his family began spending most of their winter months in St. Augustine, Florida, due to Cabell's reoccurring bouts of pneumonia. During their stay in Florida in 1949, his wife died of heart failure. In 1950, he married Margaret Waller Freeman (1893-1983), whom he had known for many years. Cabell suffered a cerebral hemorrhage in 1958, and on May 5, he died at his home in Richmond.\u003c/p\u003e","\u003cp\u003e\nCabell's writings, published in various magazines, newspapers, and anthologies, included numerous short stories, poetry, essays, book reviews, and one play. He authored more than 52 volumes of work, including three devoted to genealogy. Cabell is recognized as one of the first contemporary writers from the South. Like his friend, Ellen Glasgow, Cabell was not afraid to satirize what he saw as the South's contradictions. Others, noting Cabell's unique blending of classic myths and legends with his imagination, consider him a pioneer of fantasy writing. \u003c/p\u003e","\u003cp\u003eSoon after the establishment of Virginia Commonwealth University (VCU) in 1968, created by the merger of the Medical College of Virginia (MCV) and Richmond Professional Institute (RPI), the University began construction for a new library on the Monroe Park Campus. RPI had already planned for a new library and approached Margaret Cabell about naming it for her husband. VCU approved the name, and in 1970, the James Branch Cabell Library opened its doors.\u003c/p\u003e "],"bioghist_heading_ssm":["Biographical / Historical"],"bioghist_tesim":["Richmond author James Branch Cabell (1879-1958) is best known for his controversial book, Jurgen (1919), a fantasy set in Cabell's mythical medieval world of Poictesme (pronounced Pwa-tem). The New York Society for the Suppression of Vice contended the book was obscene. A trial over its content brought the reclusive writer national fame. Throughout the 1920s, Cabell's literary peers, including H.L. Mencken and Sinclair Lewis, praised his works.","Cabell was born April 14, 1879, at 101 E. Franklin St., the present site of the Richmond Public Library. His father was Robert Gamble Cabell, II (1847-1922), a physician; his mother Anne Harris (1859-1915), daughter of Col. and Mrs. James R. Branch. Cabell's great grandfather was William H. Cabell, governor of Virginia from 1805-1808. Cabell had two brothers, Robert Gamble Cabell, III (1881-1968) and John Lottier Cabell (1883-1946). His parents divorced in 1907.","After attending the College of William and Mary (1893-1898), where he taught courses in French and Greek while an undergraduate, Cabell worked briefly at the Richmond Times as a copyholder. In 1899 he moved to New York City and worked for the New York Herald as a social reporter. He returned to Richmond in 1901 and worked several months on the staff of the Richmond News. During the next ten years, he performed genealogical research and wrote numerous short stories and articles, which he contributed to national magazines such as Harper's Monthly Magazine and the Saturday Evening Post.","In 1911, Cabell worked as a bookkeeper for his uncle James R. Branch's coal mine in West Virginia. Returning to Richmond in 1913, he married Rebecca Priscilla Bradley Shepherd (1874-1949), a widow with five children by her previous marriage. They had one son, Ballard Hartwell Cabell (1915-1980).","Although he had written for newspapers, Cabell's first published nonfiction work was \"The Comedies of William Congreve,\" which appeared in the April 1901 edition of International. He published his first book, The Eagle's Shadow, in the autumn of 1904 after it appeared serially in the Saturday Evening Post during that summer. His work was slow to draw critical attention. However, by 1918 he had published ten major works and began attracting critical admirers. In an article for the New York Evening Mail, H.L. Mencken described Cabell as \"the only first-rate literary craftsman that the whole South can show.\" Cabell's stature and fame as an author increased with the 1919 publication of Jurgen.","On January 14, 1920, the New York State Society for the Prevention of Vice charged Cabell's publishing editor, Guy Holt, with violating the anti-obscenity provisions of the New York State Penal Code by publishing Jurgen. The controversy over the charges and the attempt at censorship brought Cabell much notoriety. Writers defended the artistry of Jurgen and Cabell's right to publish it.","The obscenity trial over Jurgen began October 16, 1922, and ended three days later with an acquittal of all charges. The presiding judge, Charles C. Nott, stated in his decision \"...the most that can be said against the book is that certain passages therein may be considered suggestive in a veiled and subtle way of immorality, but such suggestions are delicately conveyed\" and that because of Cabell's writing style \"...it is doubtful if the book could be read or understood at all by more than a very limited number of readers.\"","Throughout the 1920s, he continued to publish in the style of Jurgen, a combination of satire, symbolism, and fantasy, set in a mythical medieval French province of Poictesme. The name was a compound of two provinces located in the South of France, Poitiers and Angouleme. Cabell blended an assortment of myths and legends laced with puns, anagrams, and allegories in these books. These works eventually became part of an eighteen-volume collection entitled The Biography of the Life of Manuel; the last volume was published in 1930.","Cabell had become well regarded by prominent writers of the period and maintained an extensive correspondence with a wide circle of literary artists and friends, including Mencken, Joseph Hergesheimer, Burton Rascoe, Theodore Dreiser, Sinclair Lewis, F. Scott Fitzgerald, Carl Van Vechten, and fellow Richmonder and close friend Ellen Glasgow (1873-1945). He had known Glasgow since his days at William and Mary. He served as editor of the Virginia War History Commission (1919-1926) and later joined Dreiser, Eugene O'Neil, and others on the editorial board of the American Spectator (1932-1935). In 1937, Cabell was elected to the American Academy of Arts and Sciences.","While the controversy over Jurgen ensured Cabell an audience throughout most of the 1920s, interest in his books dropped sharply in the New Deal era of the 1930s and continued to decline. In 1932, in an attempt to break away from his past, he began publishing under the name Branch Cabell. During the next three decades, he wrote and published nearly twenty more books. They were grouped in a series of trilogies. He returned as James Branch Cabell in 1947 with the publication of Let Me Lie. It was the first installment of his fifth and last trilogy, consisting mainly of semi-autobiographical essays filled with remembrances of Virginia.","Cabell continued to live and work in Richmond, residing at 3201 Monument Avenue. By 1935 he and his family began spending most of their winter months in St. Augustine, Florida, due to Cabell's reoccurring bouts of pneumonia. During their stay in Florida in 1949, his wife died of heart failure. In 1950, he married Margaret Waller Freeman (1893-1983), whom he had known for many years. Cabell suffered a cerebral hemorrhage in 1958, and on May 5, he died at his home in Richmond.","Cabell's writings, published in various magazines, newspapers, and anthologies, included numerous short stories, poetry, essays, book reviews, and one play. He authored more than 52 volumes of work, including three devoted to genealogy. Cabell is recognized as one of the first contemporary writers from the South. Like his friend, Ellen Glasgow, Cabell was not afraid to satirize what he saw as the South's contradictions. Others, noting Cabell's unique blending of classic myths and legends with his imagination, consider him a pioneer of fantasy writing.","Soon after the establishment of Virginia Commonwealth University (VCU) in 1968, created by the merger of the Medical College of Virginia (MCV) and Richmond Professional Institute (RPI), the University began construction for a new library on the Monroe Park Campus. RPI had already planned for a new library and approached Margaret Cabell about naming it for her husband. VCU approved the name, and in 1970, the James Branch Cabell Library opened its doors."],"prefercite_html_tesm":["\u003cp\u003eJames Branch Cabell collection, Collection # M 214, Special Collections and Archives, James Branch Cabell Library, Virginia Commonwealth University, Richmond, VA.\u003c/p\u003e "],"prefercite_tesim":["James Branch Cabell collection, Collection # M 214, Special Collections and Archives, James Branch Cabell Library, Virginia Commonwealth University, Richmond, VA."],"scopecontent_html_tesm":["\u003cp\u003eThe collection contains James Branch Cabell's personal papers along with materials by other creators related to Cabell. Cabell corresponded with a number of American and British authors such as H.L. Mencken, Ellen Glasgow, Sinclair Lewis, and Theodore Dreiser, as well as with family, friends, editors and publishers. Other materials of note include his manuscripts with Cabells handwritten edits, his notebooks containing information about his published works along with poems and other writings, and the materials found inside the books of his personal library. The materials provide insight into Cabell's writings and personal interests based upon the content he placed within the books of his collection.\u003c/p\u003e","\u003cp\u003eSeries I contains correspondence between Cabell and his contemporaries in the literary world, family and friends. \u003c/p\u003e","\u003cp\u003eSeries II includes various Cabell manuscripts as story ideas, notes, early drafts, school work, essays and poems.\u003c/p\u003e","\u003cp\u003eSeries III is composed primarily of materials found placed inside Cabell's books and includes ephemera, pamphlets, newspaper clippings, etc.\u003c/p\u003e","\u003cp\u003eSeries IV are materials from the Cabell Society and contain correspondence between its founders and correspondence between Cabell and Nelson Bond and Cabell and Frederick Eddy.\u003c/p\u003e","\u003cp\u003eSeries V has materials related to the book Between Friends: Letters of James Branch Cabell and Others, edited by Padraic Colum and Margaret Freeman Cabell.\u003c/p\u003e","\u003cp\u003eSeries VI consists of various criticisms of Cabell's writings, most of which were collected by Jean Maurice Duke while writing James Branch Cabell: A Reference Guide.\u003c/p\u003e","\u003cp\u003eSeries VII includes works by Cabell printed in various periodicals. He often published essays, short stories, and other fiction in periodicals before later revising them into book form. The majority of this series is made up of bound volumes. Each volume is named for a published Cabell book and contains the full periodical where the content originally appeared before he developed it into a book.\u003c/p\u003e","\u003cp\u003eSeries VIII contains plays, poems, and other works inspired by Cabell's work.\u003c/p\u003e","\u003cp\u003eSeries IX includes scrapbooks and notebooks containing clippings, letters, notes, poems, and other writings by Cabell.\u003c/p\u003e "],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["The collection contains James Branch Cabell's personal papers along with materials by other creators related to Cabell. Cabell corresponded with a number of American and British authors such as H.L. Mencken, Ellen Glasgow, Sinclair Lewis, and Theodore Dreiser, as well as with family, friends, editors and publishers. Other materials of note include his manuscripts with Cabells handwritten edits, his notebooks containing information about his published works along with poems and other writings, and the materials found inside the books of his personal library. The materials provide insight into Cabell's writings and personal interests based upon the content he placed within the books of his collection.","Series I contains correspondence between Cabell and his contemporaries in the literary world, family and friends.","Series II includes various Cabell manuscripts as story ideas, notes, early drafts, school work, essays and poems.","Series III is composed primarily of materials found placed inside Cabell's books and includes ephemera, pamphlets, newspaper clippings, etc.","Series IV are materials from the Cabell Society and contain correspondence between its founders and correspondence between Cabell and Nelson Bond and Cabell and Frederick Eddy.","Series V has materials related to the book Between Friends: Letters of James Branch Cabell and Others, edited by Padraic Colum and Margaret Freeman Cabell.","Series VI consists of various criticisms of Cabell's writings, most of which were collected by Jean Maurice Duke while writing James Branch Cabell: A Reference Guide.","Series VII includes works by Cabell printed in various periodicals. He often published essays, short stories, and other fiction in periodicals before later revising them into book form. The majority of this series is made up of bound volumes. Each volume is named for a published Cabell book and contains the full periodical where the content originally appeared before he developed it into a book.","Series VIII contains plays, poems, and other works inspired by Cabell's work.","Series IX includes scrapbooks and notebooks containing clippings, letters, notes, poems, and other writings by Cabell."],"userestrict_html_tesm":["\u003cp\u003eThere are no restrictions.\u003c/p\u003e "],"userestrict_heading_ssm":["Use Restrictions"],"userestrict_tesim":["There are no restrictions."],"corpname_ssim":["VCU James Branch Cabell Library"],"persname_ssim":["Cabell, James Branch, 1879-1958","Flora, Joseph M."],"names_coll_ssim":["Cabell, James Branch, 1879-1958","Flora, Joseph M."],"names_ssim":["VCU James Branch Cabell Library","Cabell, James Branch, 1879-1958","Flora, Joseph M."],"language_ssim":["English"],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":493,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:40:16.668Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/vircu_repositories_5_resources_96_c07_c17_c10"}},{"id":"viu_repositories_7_resources_1710_c02_c263","type":"Item","attributes":{"title":"The Line of Investigation Which was Proposed for Mr. Dunn, 1900/1930","abstract_or_scope":{"id":"https://search.arvasarchive.org/catalog/viu_repositories_7_resources_1710_c02_c263#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003e[Hanson] suggests details for Dunn's investigation of mosquitoes.\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/viu_repositories_7_resources_1710_c02_c263#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_7_resources_1710_c02_c263","ref_ssm":["viu_repositories_7_resources_1710_c02_c263"],"id":"viu_repositories_7_resources_1710_c02_c263","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710_c02","parent_ssi":"viu_repositories_7_resources_1710_c02","parent_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932"],"parent_ids_ssim":["viu_repositories_7_resources_1710","viu_repositories_7_resources_1710_c02"],"title_filing_ssi":"The Line of Investigation Which was Proposed for Mr. Dunn","title_ssm":["The Line of Investigation Which was Proposed for Mr. Dunn"],"title_tesim":["The Line of Investigation Which was Proposed for Mr. Dunn"],"normalized_title_ssm":["The Line of Investigation Which was Proposed for Mr. Dunn, 1900/1930"],"text":["The Line of Investigation Which was Proposed for Mr. Dunn, 1900/1930","Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932","box 13","folder 30","Mosquitoes","Public health","reports","English","[Hanson] suggests details for Dunn's investigation of mosquitoes."],"parent_unittitles_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932"],"parent_unittitles_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","Series II. Henry Rose Carter, 1880/1932, bulk 1883/1932"],"normalized_date_ssm":["1900/1930"],"unitdate_inclusive_ssm":["circa 1900-1930"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[2],"sort_isi":1884,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"extent_ssm":["2 pages"],"extent_tesim":["2 pages"],"containers_ssim":["box 13","folder 30"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"parent_access_terms_tesm":["Copyright restrictions may apply for some materials in the collection."],"access_subjects_ssim":["Mosquitoes","Public health","reports"],"access_subjects_ssm":["Mosquitoes","Public health","reports"],"language_ssim":["English"],"date_range_isim":[1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930],"scopecontent_html_tesm":["\u003cp\u003e[Hanson] suggests details for Dunn's investigation of mosquitoes.\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["[Hanson] suggests details for Dunn's investigation of mosquitoes."],"_nest_path_":"/components#1/components#262","timestamp":"2026-08-14T22:54:59.526Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_7_resources_1710","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","ead_source_url_ssi":"data/oai/UVA/repositories_7_resources_1710.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/202324","title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection"],"title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection"],"unitdate_ssm":["circa 1800-circa 1998","bulk 1863-1974"],"unitdate_inclusive_ssm":["circa 1800-circa 1998"],"unitdate_bulk_ssim":["bulk 1863-1974"],"normalized_date_ssm":["1800/1998, bulk 1863/1974"],"normalized_title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"text":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","MS.1","Archival Resource Key","/repositories/7/resources/1710","Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever","There are no restrictions on user access to any of the materials in the collection except where noted in the container list.","The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n II. Henry Rose Carter\n III. Walter Reed\n IV. Philip Showalter Hench\n V. Maps\n VI. Alphabetical files\n VII. Truby-Kean-Hench\n VIII. Miscellany\n IX. Photographs\n X. Photographic negatives\n XI. Reprints\n XII. Houston Academy of Medicine/Texas Medical Center additions\n XIII. Reed family additions\n XIV. P. Kahler Hench additions\n XV. Laura Wood\n XVI. Edward Hook additions","The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n When does a mosquito develop the ability to transmit the disease?\n Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [16] Please see note [7].\n [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.","Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n Series II. Henry Rose Carter\n Series III. Walter Reed\n Series IV. Philip Showalter Hench\n Series V. Maps\n Series VI. Alphabetical files\n Series VII. Truby-Kean-Hench\n Series VIII. Miscellany\n Series IX. Photographs\n Series X. Negatives\n Series XI. Reprints\n Series XIII. Reed family additions\n Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.","Processed by:\n Historical Collections Staff","Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n correspondence of other Lazear family members (e.g. Jesse's parents);\n genealogical summaries and tables relating to the Lazear family;\n legal documents (e.g. wills, certificates, deeds);\n military records relating to Jesse;\n certificates, reports, and other materials documenting Jesse's educational background and achievements;\n obituaries;\n copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n newspaper articles;\n a microscope and sets of microscope slides owned by Jesse;\n and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n journal articles concerning the study and eradication of yellow fever and malaria;\n research notes written by Henry Rose Carter;\n and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n condolence letters for Henry Rose Carter's family after Henry's death;\n and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n articles announcing the death of Walter Reed;\n and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n scientific reports and publications related to the study and eradication of yellow fever and malaria;\n and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n autobiographical accounts of the experiment's participants and their families;\n notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n scripts for radio programs relating to the yellow fever experiments;\n notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n Cuba;\n sites associated with the yellow fever experiments;\n and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n other correspondence;\n newspaper and magazine clippings;\n unpublished manuscripts;\n biographical and autobiographical accounts;\n transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n articles and clippings related to the yellow fever experiments;\n a short biography of Lemuel S. Reed;\n and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n diplomas and certificates for Walter Reed and Jesse W. Lazear;\n copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n correspondence of Philip Showalter Hench from circa 1940 to 1966;\n articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n photographs relating to Cuba and the yellow fever experiments;\n notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n the U.S.S.Maineand the Spanish-American War;\n aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n scenes of daily life in Cuba generally from between 1898 and 1960;\n the 1952 dedication of the Camp Lazear National Monument in Cuba;\n the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n still scenes from the movies,Yellow JackandJezebel;\n other events and works of art commemorating the work of the participants in the yellow fever experiments;\n documents and maps that Philip Showalter Hench copied for his research;\n and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n biographical accounts of various people who had an association with the yellow fever experiments;\n the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n scientific and medical research related to yellow fever and malaria;\n and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n newspaper clippings and articles relating to the yellow fever experiments;\n a chemistry notebook that was owned by Walter Reed;\n correspondence of and works by Philip Showalter Hench;\n an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n correspondence between Philip Showalter Hench and the experiment participants;\n correspondence between Philip Showalter Hench and families of the experiment participants;\n press clippings relating to the experiments and the experiment participants;\n oral history interviews conducted by Philip Showalter Hench;\n scientific articles related to the study of yellow fever;\n photographs of Havana, Camp Columbia, and Camp Lazear;\n genealogical tables and summaries for the family of Jesse W. Lazear;\n autobiographical accounts written by experiment participants;\n unpublished manuscripts;\n artifacts (e.g. a wooden board) from Camp Lazear;\n Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n a journal article by George Sternberg;\n and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.","Copyright restrictions may apply for some materials in the collection.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.","Claude Moore Health Sciences Library","Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"collection_title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"unitid_tesim":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_corpname_ssim":["Claude Moore Health Sciences Library"],"creators_ssim":["Claude Moore Health Sciences Library"],"access_terms_ssm":["Copyright restrictions may apply for some materials in the collection."],"acqinfo_ssim":["Materials from the following series were donated to the University of Virginia's Alderman Library in the fall of 1966 and the summer of 1970 by Philip Showalter Hench's widow, Mary Kahler Hench, with the approval of his estate:","Series I. Jesse W. Lazear\n Series II. Henry Rose Carter\n Series III. Walter Reed\n Series IV. Philip Showalter Hench\n Series V. Maps\n Series VI. Alphabetical files\n Series VII. Truby-Kean-Hench\n Series VIII. Miscellany\n Series IX. Photographs\n Series X. Negatives\n Series XI. Reprints","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were donated to the HAM/TMC by Philip Showalter Hench as a small part of a larger collection of materials.","Materials from Series XIII. Reed family additions were donated by various individuals to Alderman Library between 1947 and 1972. Box 139, Folder 1 contains a list that describes each of these donations in detail.","Materials from Series XIV. P. Kahler Hench were donated to the Claude Moore Health Sciences Library by Philip Showalter Hench's son, P. Kahler Hench, in 1988 and 1989.","Materials from Series XV. Laura Wood were most likely donated to Alderman Library between 1972 and 1982.","Materials from Series XVI. Edward Hook additions were donated to the Claude Moore Health Sciences Library as a part of the Papers of Dr. Edward Watson Hook, Jr."],"access_subjects_ssim":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"access_subjects_ssm":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"has_online_content_ssim":["false"],"extent_ssm":["67 Linear Feet 154 boxes"],"extent_tesim":["67 Linear Feet 154 boxes"],"date_range_isim":[1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998],"accessrestrict_html_tesm":["\u003cp\u003eThere are no restrictions on user access to any of the materials in the collection except where noted in the container list.\u003c/p\u003e "],"accessrestrict_heading_ssm":["Access"],"accessrestrict_tesim":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"arrangement_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eI. Jesse W. Lazear\u003c/item\u003e\n \u003citem\u003eII. Henry Rose Carter\u003c/item\u003e\n \u003citem\u003eIII. Walter Reed\u003c/item\u003e\n \u003citem\u003eIV. Philip Showalter Hench\u003c/item\u003e\n \u003citem\u003eV. Maps\u003c/item\u003e\n \u003citem\u003eVI. Alphabetical files\u003c/item\u003e\n \u003citem\u003eVII. Truby-Kean-Hench\u003c/item\u003e\n \u003citem\u003eVIII. Miscellany\u003c/item\u003e\n \u003citem\u003eIX. Photographs\u003c/item\u003e\n \u003citem\u003eX. Photographic negatives\u003c/item\u003e\n \u003citem\u003eXI. Reprints\u003c/item\u003e\n \u003citem\u003eXII. Houston Academy of Medicine/Texas Medical Center additions\u003c/item\u003e\n \u003citem\u003eXIII. Reed family additions\u003c/item\u003e\n \u003citem\u003eXIV. P. Kahler Hench additions\u003c/item\u003e\n \u003citem\u003eXV. Laura Wood\u003c/item\u003e\n \u003citem\u003eXVI. Edward Hook additions\u003c/item\u003e\n \u003c/list\u003e\n "],"arrangement_heading_ssm":["Organization of the Collection"],"arrangement_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n II. Henry Rose Carter\n III. Walter Reed\n IV. Philip Showalter Hench\n V. Maps\n VI. Alphabetical files\n VII. Truby-Kean-Hench\n VIII. Miscellany\n IX. Photographs\n X. Photographic negatives\n XI. Reprints\n XII. Houston Academy of Medicine/Texas Medical Center additions\n XIII. Reed family additions\n XIV. P. Kahler Hench additions\n XV. Laura Wood\n XVI. Edward Hook additions"],"bioghist_heading_ssm":["Historical Information for the U.S. Army Yellow Fever Commission","Biographical Information for Walter Reed","Biographical Information for Jesse W. Lazear","Biographical Information for Henry Rose Carter","Biographical Information for Jefferson Randolph Kean","Biographical Information for Philip Showalter Hench"],"bioghist_tesim":["The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n When does a mosquito develop the ability to transmit the disease?\n Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n [16] Please see note [7].\n [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001."],"custodhist_html_tesm":["\u003cp\u003eMaterials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eSeries I. Jesse W. Lazear\u003c/item\u003e\n \u003citem\u003eSeries II. Henry Rose Carter\u003c/item\u003e\n \u003citem\u003eSeries III. Walter Reed\u003c/item\u003e\n \u003citem\u003eSeries IV. Philip Showalter Hench\u003c/item\u003e\n \u003citem\u003eSeries V. Maps\u003c/item\u003e\n \u003citem\u003eSeries VI. Alphabetical files\u003c/item\u003e\n \u003citem\u003eSeries VII. Truby-Kean-Hench\u003c/item\u003e\n \u003citem\u003eSeries VIII. Miscellany\u003c/item\u003e\n \u003citem\u003eSeries IX. Photographs\u003c/item\u003e\n \u003citem\u003eSeries X. Negatives\u003c/item\u003e\n \u003citem\u003eSeries XI. Reprints\u003c/item\u003e\n \u003citem\u003eSeries XIII. Reed family additions\u003c/item\u003e\n \u003citem\u003eSeries XV. Laura Wood\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eMaterials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.\u003c/p\u003e","\u003cp\u003e Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.\u003c/p\u003e "],"custodhist_heading_ssm":["Custodial History"],"custodhist_tesim":["Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n Series II. Henry Rose Carter\n Series III. Walter Reed\n Series IV. Philip Showalter Hench\n Series V. Maps\n Series VI. Alphabetical files\n Series VII. Truby-Kean-Hench\n Series VIII. Miscellany\n Series IX. Photographs\n Series X. Negatives\n Series XI. Reprints\n Series XIII. Reed family additions\n Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s."],"odd_html_tesm":["\u003clist type=\"deflist\"\u003e\n \u003cdefitem\u003e\n \u003clabel\u003eProcessed by:\u003c/label\u003e\n \u003citem\u003eHistorical Collections Staff\u003c/item\u003e\n \u003c/defitem\u003e\n \u003c/list\u003e\n "],"odd_heading_ssm":["General"],"odd_tesim":["Processed by:\n Historical Collections Staff"],"prefercite_html_tesm":["\u003cp\u003ePhilip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia\u003c/p\u003e "],"prefercite_tesim":["Philip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia"],"processinfo_html_tesm":["\u003cp\u003eMary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.\u003c/p\u003e","\u003cp\u003e Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.\u003c/p\u003e","\u003cp\u003e In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.\u003c/p\u003e","\u003cp\u003e Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.\u003c/p\u003e","\u003cp\u003e Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.\u003c/p\u003e","\u003cp\u003e In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.\u003c/p\u003e","\u003cp\u003e In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.\u003c/p\u003e","\u003cp\u003e In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.\u003c/p\u003e "],"processinfo_heading_ssm":["Processing History"],"processinfo_tesim":["Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog."],"scopecontent_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","\u003cp\u003e In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ethe diaries documenting the travels of Jesse and Mabel's mothers in Europe;\u003c/item\u003e\n \u003citem\u003ecorrespondence of other Lazear family members (e.g. Jesse's parents);\u003c/item\u003e\n \u003citem\u003egenealogical summaries and tables relating to the Lazear family;\u003c/item\u003e\n \u003citem\u003elegal documents (e.g. wills, certificates, deeds);\u003c/item\u003e\n \u003citem\u003emilitary records relating to Jesse;\u003c/item\u003e\n \u003citem\u003ecertificates, reports, and other materials documenting Jesse's educational background and achievements;\u003c/item\u003e\n \u003citem\u003eobituaries;\u003c/item\u003e\n \u003citem\u003ecopies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\u003c/item\u003e\n \u003citem\u003enewspaper articles;\u003c/item\u003e\n \u003citem\u003ea microscope and sets of microscope slides owned by Jesse;\u003c/item\u003e\n \u003citem\u003eand a medical chart that shows the progression of the yellow fever infection that killed Jesse.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\u003c/item\u003e\n \u003citem\u003escientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\u003c/item\u003e\n \u003citem\u003ejournal articles concerning the study and eradication of yellow fever and malaria;\u003c/item\u003e\n \u003citem\u003eresearch notes written by Henry Rose Carter;\u003c/item\u003e\n \u003citem\u003eand photographs of Henry Rose Carter at work and with professional colleagues.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.\u003c/p\u003e","\u003cp\u003e In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecopies of obituaries for Henry Rose Carter;\u003c/item\u003e\n \u003citem\u003econdolence letters for Henry Rose Carter's family after Henry's death;\u003c/item\u003e\n \u003citem\u003eand the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\u003c/item\u003e\n \u003citem\u003emilitary records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\u003c/item\u003e\n \u003citem\u003eWalter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\u003c/item\u003e\n \u003citem\u003emedical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\u003c/item\u003e\n \u003citem\u003earticles announcing the death of Walter Reed;\u003c/item\u003e\n \u003citem\u003eand the shoulder boards from Walter Reed's U.S. Army uniform.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003earticles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\u003c/item\u003e\n \u003citem\u003ebiographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n \u003citem\u003erecords relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\u003c/item\u003e\n \u003citem\u003ecopies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n \u003citem\u003eand letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003e.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eFinally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eitems (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\u003c/item\u003e\n \u003citem\u003ematerials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\u003c/item\u003e\n \u003citem\u003escientific reports and publications related to the study and eradication of yellow fever and malaria;\u003c/item\u003e\n \u003citem\u003eand newspaper articles describing various outbreaks of yellow fever epidemics.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eHench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\u003c/item\u003e\n \u003citem\u003eautobiographical accounts of the experiment's participants and their families;\u003c/item\u003e\n \u003citem\u003enotes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\u003c/item\u003e\n \u003citem\u003ecorrespondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\u003c/item\u003e\n \u003citem\u003ecorrespondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\u003c/item\u003e\n \u003citem\u003enewspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\u003c/item\u003e\n \u003citem\u003edrafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\u003c/item\u003e\n \u003citem\u003emeeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\u003c/item\u003e\n \u003citem\u003escripts for radio programs relating to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003enotes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\u003c/item\u003e\n \u003citem\u003eand the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eHavana and its environs;\u003c/item\u003e\n \u003citem\u003eCuba;\u003c/item\u003e\n \u003citem\u003esites associated with the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003eand military installations in the United States.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.\u003c/p\u003e","\u003cp\u003e Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and the individuals;\u003c/item\u003e\n \u003citem\u003eother correspondence;\u003c/item\u003e\n \u003citem\u003enewspaper and magazine clippings;\u003c/item\u003e\n \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n \u003citem\u003ebiographical and autobiographical accounts;\u003c/item\u003e\n \u003citem\u003etranscripts of oral history interviews that were conducted by Philip Showalter Hench;\u003c/item\u003e\n \u003citem\u003eand copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.\u003c/p\u003e","\u003cp\u003e Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\u003c/item\u003e\n \u003citem\u003ePhilip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\u003c/item\u003e\n \u003citem\u003ea scrapbook and other materials that relate to Truby's book,\u003ctitle render=\"italic\"\u003eMemoir of Walter Reed: the Yellow Fever Episode\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003eand Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials relating to Kean and Truby, Series VII. also includes the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003enotes from Philip Showalter Hench's research of the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ethe recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\u003c/item\u003e\n \u003citem\u003earticles and clippings related to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ea short biography of Lemuel S. Reed;\u003c/item\u003e\n \u003citem\u003eand a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003einformed consent agreements for volunteers in the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ediplomas and certificates for Walter Reed and Jesse W. Lazear;\u003c/item\u003e\n \u003citem\u003ecopies and sketches of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003eartifacts, including a wooden board from Camp Lazear and a U.S. flag;\u003c/item\u003e\n \u003citem\u003ecopies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003emanuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ecorrespondence of Philip Showalter Hench from circa 1940 to 1966;\u003c/item\u003e\n \u003citem\u003earticles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n \u003citem\u003ecorrespondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n \u003citem\u003eitems that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n \u003citem\u003ephotographs relating to Cuba and the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003enotes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ephysicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\u003c/item\u003e\n \u003citem\u003efamily members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\u003c/item\u003e\n \u003citem\u003eCamp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\u003c/item\u003e\n \u003citem\u003ethe U.S.S.\u003cemph render=\"italic\"\u003eMaine\u003c/emph\u003eand the Spanish-American War;\u003c/item\u003e\n \u003citem\u003eaerial views of Havana, Cuba and its environs from the 1940s and 1950s;\u003c/item\u003e\n \u003citem\u003escenes of daily life in Cuba generally from between 1898 and 1960;\u003c/item\u003e\n \u003citem\u003ethe 1952 dedication of the Camp Lazear National Monument in Cuba;\u003c/item\u003e\n \u003citem\u003ethe creation and unveiling of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003estill scenes from the movies,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003eand\u003ctitle render=\"italic\"\u003eJezebel\u003c/title\u003e;\u003c/item\u003e\n \u003citem\u003eother events and works of art commemorating the work of the participants in the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003edocuments and maps that Philip Showalter Hench copied for his research;\u003c/item\u003e\n \u003citem\u003eand Philip Showalter Hench and his family.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries IX. also includes a watercolor that was painted by Emilie Lawrence Reed.\u003c/p\u003e","\u003cp\u003e Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.\u003c/p\u003e","\u003cp\u003e The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.\u003c/p\u003e","\u003cp\u003e Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ethe results of the U.S. Army Yellow Fever Commission's work in Cuba;\u003c/item\u003e\n \u003citem\u003ebiographical accounts of various people who had an association with the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ethe research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\u003c/item\u003e\n \u003citem\u003escientific and medical research related to yellow fever and malaria;\u003c/item\u003e\n \u003citem\u003eand events honoring the work of those involved with the yellow fever experiments.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\u003c/item\u003e\n \u003citem\u003enewspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ephotographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\u003c/item\u003e\n \u003citem\u003eand journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.\u003c/p\u003e","\u003cp\u003e In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ea flag that was flown over Camp Lazear;\u003c/item\u003e\n \u003citem\u003enewspaper clippings and articles relating to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ea chemistry notebook that was owned by Walter Reed;\u003c/item\u003e\n \u003citem\u003ecorrespondence of and works by Philip Showalter Hench;\u003c/item\u003e\n \u003citem\u003ean inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\u003c/item\u003e\n \u003citem\u003eand materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ethe correspondence of experiment participants;\u003c/item\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and the experiment participants;\u003c/item\u003e\n \u003citem\u003ecorrespondence between Philip Showalter Hench and families of the experiment participants;\u003c/item\u003e\n \u003citem\u003epress clippings relating to the experiments and the experiment participants;\u003c/item\u003e\n \u003citem\u003eoral history interviews conducted by Philip Showalter Hench;\u003c/item\u003e\n \u003citem\u003escientific articles related to the study of yellow fever;\u003c/item\u003e\n \u003citem\u003ephotographs of Havana, Camp Columbia, and Camp Lazear;\u003c/item\u003e\n \u003citem\u003egenealogical tables and summaries for the family of Jesse W. Lazear;\u003c/item\u003e\n \u003citem\u003eautobiographical accounts written by experiment participants;\u003c/item\u003e\n \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n \u003citem\u003eartifacts (e.g. a wooden board) from Camp Lazear;\u003c/item\u003e\n \u003citem\u003ePhilip Showalter Hench's research notes.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eSeries XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.\u003c/p\u003e","\u003cp\u003e Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ephotocopies of two letters written by Walter Reed;\u003c/item\u003e\n \u003citem\u003ea journal article by George Sternberg;\u003c/item\u003e\n \u003citem\u003eand a short work that Laura Wood wrote about Walter Reed entitled,\u003ctitle render=\"italic\"\u003eWalter Reed and yellow Fever\u003c/title\u003e.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eItems in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.\u003c/p\u003e","\u003cp\u003e Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003ephotographs of Walter Reed and others related to the yellow fever experiments;\u003c/item\u003e\n \u003citem\u003ecopies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\u003c/item\u003e\n \u003citem\u003eand exhibition materials.\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eItems in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.\u003c/p\u003e "],"scopecontent_heading_ssm":["Scope and Content Information"],"scopecontent_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n correspondence of other Lazear family members (e.g. Jesse's parents);\n genealogical summaries and tables relating to the Lazear family;\n legal documents (e.g. wills, certificates, deeds);\n military records relating to Jesse;\n certificates, reports, and other materials documenting Jesse's educational background and achievements;\n obituaries;\n copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n newspaper articles;\n a microscope and sets of microscope slides owned by Jesse;\n and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n journal articles concerning the study and eradication of yellow fever and malaria;\n research notes written by Henry Rose Carter;\n and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n condolence letters for Henry Rose Carter's family after Henry's death;\n and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n articles announcing the death of Walter Reed;\n and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n scientific reports and publications related to the study and eradication of yellow fever and malaria;\n and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n autobiographical accounts of the experiment's participants and their families;\n notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n scripts for radio programs relating to the yellow fever experiments;\n notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n Cuba;\n sites associated with the yellow fever experiments;\n and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n other correspondence;\n newspaper and magazine clippings;\n unpublished manuscripts;\n biographical and autobiographical accounts;\n transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n articles and clippings related to the yellow fever experiments;\n a short biography of Lemuel S. Reed;\n and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n diplomas and certificates for Walter Reed and Jesse W. Lazear;\n copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n correspondence of Philip Showalter Hench from circa 1940 to 1966;\n articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n photographs relating to Cuba and the yellow fever experiments;\n notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n the U.S.S.Maineand the Spanish-American War;\n aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n scenes of daily life in Cuba generally from between 1898 and 1960;\n the 1952 dedication of the Camp Lazear National Monument in Cuba;\n the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n still scenes from the movies,Yellow JackandJezebel;\n other events and works of art commemorating the work of the participants in the yellow fever experiments;\n documents and maps that Philip Showalter Hench copied for his research;\n and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n biographical accounts of various people who had an association with the yellow fever experiments;\n the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n scientific and medical research related to yellow fever and malaria;\n and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n newspaper clippings and articles relating to the yellow fever experiments;\n a chemistry notebook that was owned by Walter Reed;\n correspondence of and works by Philip Showalter Hench;\n an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n correspondence between Philip Showalter Hench and the experiment participants;\n correspondence between Philip Showalter Hench and families of the experiment participants;\n press clippings relating to the experiments and the experiment participants;\n oral history interviews conducted by Philip Showalter Hench;\n scientific articles related to the study of yellow fever;\n photographs of Havana, Camp Columbia, and Camp Lazear;\n genealogical tables and summaries for the family of Jesse W. Lazear;\n autobiographical accounts written by experiment participants;\n unpublished manuscripts;\n artifacts (e.g. a wooden board) from Camp Lazear;\n Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n a journal article by George Sternberg;\n and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901."],"userestrict_html_tesm":["\u003cp\u003eCopyright restrictions may apply for some materials in the collection.\u003c/p\u003e "],"userestrict_heading_ssm":["Copyright Status"],"userestrict_tesim":["Copyright restrictions may apply for some materials in the collection."],"abstract_html_tesm":["\u003cabstract id=\"aspace_98fe81a152b4be0b7388b1814ffaf4bd\"\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.\u003c/abstract\u003e\n "],"abstract_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission."],"corpname_ssim":["Claude Moore Health Sciences Library"],"names_ssim":["Claude Moore Health Sciences Library"],"language_ssim":["Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":10452,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:54:59.526Z","bioghist_html_tesm":["\u003cp\u003eThe U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.\u003c/p\u003e","\u003cp\u003e When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.\u003c/p\u003e","\u003cp\u003e The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.\u003c/p\u003e","\u003cp\u003e In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.\u003c/p\u003e","\u003cp\u003e Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued that\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003ewas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.\u003c/p\u003e","\u003cp\u003e Despite Wasdin and Geddings' insistence, the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003etheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of the\u003cemph render=\"italic\"\u003eicteroides\u003c/emph\u003eproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003equestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.\u003c/p\u003e","\u003cp\u003e Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identified\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003ein tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.\u003c/p\u003e","\u003cp\u003e What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.\u003c/p\u003e","\u003cp\u003e \"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.\u003c/p\u003e","\u003cp\u003e Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.\u003c/p\u003e","\u003cp\u003e On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.\u003c/p\u003e","\u003cp\u003e These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.\u003c/p\u003e","\u003cp\u003e Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.\u003c/p\u003e","\u003cp\u003e Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.\u003c/p\u003e","\u003cp\u003e The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the variety\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003e(later called\u003cemph render=\"italic\"\u003eStegomyia fasciata\u003c/emph\u003e, and later still\u003cemph render=\"italic\"\u003eAedes aegypti\u003c/emph\u003e) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003eHow could a building become infected?\u003c/item\u003e\n \u003citem\u003eWhen does a mosquito develop the ability to transmit the disease?\u003c/item\u003e\n \u003citem\u003eOver what length of time can a mosquito retain this capacity to infect?\u003c/item\u003e\n \u003c/list\u003e\n","\u003cp\u003eThe second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.\u003c/p\u003e","\u003cp\u003e The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.\u003c/p\u003e","\u003cp\u003e The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.\u003c/p\u003e","\u003cp\u003e Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.\u003cemph render=\"italic\"\u003eCulex pungens\u003c/emph\u003efailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated that\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas the only species capable of transmitting yellow fever. [11]\u003c/p\u003e","\u003cp\u003e A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle the\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003equestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow any\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003e, conclusively invalidating Sanarelli's claim.\u003c/p\u003e","\u003cp\u003e Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.\u003c/p\u003e","\u003cp\u003e Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:\u003c/p\u003e","\u003cp\u003e \"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"\u003c/p\u003e","\u003cp\u003e \"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]\u003c/p\u003e","\u003cp\u003e The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.\u003c/p\u003e","\u003cp\u003e That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.\u003c/p\u003e","\u003cp\u003e The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.\u003c/p\u003e","\u003cp\u003e For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.\u003c/p\u003e","\u003cp\u003e Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper as\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e, published immediately in the\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e. [16]\u003c/p\u003e","\u003cp\u003e Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Walter Reed and James Carroll,\u003ctitle render=\"doublequote\"\u003eBacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical News\u003c/title\u003e(29 April 1899), reprinted in: United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever, A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 55.\u003c/item\u003e\n \u003citem\u003e[2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\u003c/item\u003e\n \u003citem\u003e[3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 94.\u003c/item\u003e\n \u003citem\u003e[4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\u003c/item\u003e\n \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association\u003c/title\u003eIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/item\u003e\n \u003citem\u003e[6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\u003c/item\u003e\n \u003citem\u003e[7] Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\u003c/item\u003e\n \u003citem\u003e[8] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n \u003citem\u003e[9] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n \u003citem\u003e[10] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 101.\u003c/item\u003e\n \u003citem\u003e[11]\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas reclassified shortly after the experiments as\u003cemph render=\"italic\"\u003eStegomyia\u003c/emph\u003eand later became\u003cemph render=\"italic\"\u003eAedes aegypti.\u003c/emph\u003e\u003c/item\u003e\n \u003citem\u003e[12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\u003c/item\u003e\n \u003citem\u003e[13] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 97.\u003c/item\u003e\n \u003citem\u003e[14] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 98.\u003c/item\u003e\n \u003citem\u003e[15] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n \u003citem\u003e[16] Please see note [7].\u003c/item\u003e\n \u003citem\u003e[17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eExperimental Yellow Fever\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eII (6 July 1901) 1: 15-23.\u003c/item\u003e\n \u003citem\u003e[18] Walter Reed, James Carroll,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever (A Supplemental Note)\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eIII (22 February 1902) 8: 301-305.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eWalter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.\u003c/p\u003e","\u003cp\u003e Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.\u003c/p\u003e","\u003cp\u003e At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.\u003c/p\u003e","\u003cp\u003e Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.\u003c/p\u003e","\u003cp\u003e Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.\u003c/p\u003e","\u003cp\u003e Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.\u003c/p\u003e","\u003cp\u003e Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in the\u003ctitle render=\"italic\"\u003eArmy Register\u003c/title\u003e, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\u003c/item\u003e\n \u003citem\u003e[2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,\u003ctitle render=\"italic\"\u003eWalter Reed and Yellow Fever\u003c/title\u003e(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eJesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.\u003c/p\u003e","\u003cp\u003e \"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.\u003c/p\u003e","\u003cp\u003e Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]\u003c/p\u003e","\u003cp\u003e These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on the\u003cemph render=\"italic\"\u003eAnopheles\u003c/emph\u003emosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.\u003c/p\u003e","\u003cp\u003e The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship of\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.\u003c/p\u003e","\u003cp\u003e The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.\u003c/p\u003e","\u003cp\u003e Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.\u003c/p\u003e","\u003cp\u003e [1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\u003c/item\u003e\n \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n \u003citem\u003e[4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\u003c/item\u003e\n \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note,\u003c/title\u003e \u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/title\u003e\u003c/item\u003e\n \u003citem\u003e[6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\u003c/item\u003e\n \u003citem\u003e[7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\u003c/item\u003e\n \u003citem\u003e[8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eHenry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.\u003c/p\u003e","\u003cp\u003e Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.\u003c/p\u003e","\u003cp\u003e Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]\u003c/p\u003e","\u003cp\u003e Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in the\u003ctitle render=\"italic\"\u003eNew Orleans Medical and Surgical Journal\u003c/title\u003e, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]\u003c/p\u003e","\u003cp\u003e Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003e[5]\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] T. H. D. Griffitts,\u003ctitle render=\"doublequote\"\u003eHenry Rose Carter: The Scientist and the Man\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eSouthern Medical Journal\u003c/title\u003e32 (August 1939) 8: 842.\u003c/item\u003e\n \u003citem\u003e[2] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n \u003citem\u003e[4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\u003c/item\u003e\n \u003citem\u003e[5] Carter, Henry Rose.\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003eBaltimore: The Williams and Wilkins Company, 1931.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003eJefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.\u003c/p\u003e","\u003cp\u003e \"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.\u003c/p\u003e","\u003cp\u003e Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.\u003c/p\u003e","\u003cp\u003e In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,\u003ctitle render=\"italic\"\u003eThe Military Surgeon\u003c/title\u003e, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\u003c/item\u003e\n \u003citem\u003e[2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\u003c/item\u003e\n \u003citem\u003e[3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.\u003c/item\u003e\n \u003c/list\u003e\n ","\u003cp\u003ePhilip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.\u003c/p\u003e","\u003cp\u003e Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.\u003c/p\u003e","\u003cp\u003e The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.\u003c/p\u003e","\u003cp\u003e For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.\u003c/p\u003e","\u003cp\u003e In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e ","\u003clist type=\"ordered\"\u003e\n \u003citem\u003e[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\u003c/item\u003e\n \u003citem\u003e[2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.\u003c/item\u003e\n \u003c/list\u003e\n "]}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/viu_repositories_7_resources_1710_c02_c263"}},{"id":"viw_repositories_2_resources_8562_c01_c03_c08","type":"Item","attributes":{"title":"Theodore Roosevelt, The White House, Washington, D.C., to Robert M. Hughes, Norfolk, Virginia, 1906","abstract_or_scope":{"id":"https://search.arvasarchive.org/catalog/viw_repositories_2_resources_8562_c01_c03_c08#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eTypewritten Letter Signed. Concerning Hughes' biography of General [Joseph E.] Johnston.\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/viw_repositories_2_resources_8562_c01_c03_c08#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viw_repositories_2_resources_8562_c01_c03_c08","ref_ssm":["viw_repositories_2_resources_8562_c01_c03_c08"],"id":"viw_repositories_2_resources_8562_c01_c03_c08","ead_ssi":"viw_repositories_2_resources_8562","_root_":"viw_repositories_2_resources_8562","_nest_parent_":"viw_repositories_2_resources_8562_c01_c03","parent_ssi":"viw_repositories_2_resources_8562_c01_c03","parent_ssim":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933","Series 1: Personal and business correspondence","Personal and business correspondence, 1901/1910"],"parent_ids_ssim":["viw_repositories_2_resources_8562","viw_repositories_2_resources_8562_c01","viw_repositories_2_resources_8562_c01_c03"],"title_filing_ssi":"Theodore Roosevelt, The White House, Washington, D.C., to Robert M. Hughes, Norfolk, Virginia","title_ssm":["Theodore Roosevelt, The White House, Washington, D.C., to Robert M. Hughes, Norfolk, Virginia"],"title_tesim":["Theodore Roosevelt, The White House, Washington, D.C., to Robert M. Hughes, Norfolk, Virginia"],"normalized_title_ssm":["Theodore Roosevelt, The White House, Washington, D.C., to Robert M. Hughes, Norfolk, Virginia, 1906"],"text":["Theodore Roosevelt, The White House, Washington, D.C., to Robert M. Hughes, Norfolk, Virginia, 1906","Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933","Series 1: Personal and business correspondence","Personal and business correspondence, 1901/1910","Box 1","Folder 3","Typewritten Letter Signed. Concerning Hughes' biography of General [Joseph E.] Johnston."],"parent_unittitles_ssm":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933","Series 1: Personal and business correspondence","Personal and business correspondence, 1901/1910"],"parent_unittitles_tesim":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933","Series 1: Personal and business correspondence","Personal and business correspondence, 1901/1910"],"normalized_date_ssm":["1906"],"unitdate_inclusive_ssm":["1906 May 19"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[3],"sort_isi":48,"repository_ssim":["College of William and Mary"],"collection_ssim":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933"],"containers_ssim":["Box 1","Folder 3"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["Collection is open to all researchers. Manuscript collections and archival records may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations, such as the Virginia Public Records Act (Code of Virginia. § 42.1-76-91); and the Virginia Freedom of Information Act (Code of Virginia § 2.2-3705.5). Confidential material may include, but is not limited to, educational, medical, and personnel records. If sensitive material is found in this collection, please contact a staff member immediately. The disclosure of personally identifiable information pertaining to a living individual may have legal consequences for which the College of William and Mary assumes no responsibility."],"parent_access_terms_tesm":["Before reproducing or quoting from any materials, in whole or in part, permission must be obtained from the Special Collections Research Center, and the holder of the copyright, if not Swem Library."],"date_range_isim":[1906],"scopecontent_html_tesm":["\u003cp\u003eTypewritten Letter Signed. Concerning Hughes' biography of General [Joseph E.] Johnston.\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Typewritten Letter Signed. Concerning Hughes' biography of General [Joseph E.] Johnston."],"_nest_path_":"/components#0/components#2/components#7","timestamp":"2026-08-14T23:04:15.155Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viw_repositories_2_resources_8562","ead_ssi":"viw_repositories_2_resources_8562","_root_":"viw_repositories_2_resources_8562","_nest_parent_":"viw_repositories_2_resources_8562","ead_source_url_ssi":"data/oai/WM/repositories_2_resources_8562.xml","title_filing_ssi":"Hughes, Robert Morton Papers","title_ssm":["Robert Morton Hughes Papers"],"title_tesim":["Robert Morton Hughes Papers"],"unitdate_ssm":["1715-1940","1871-1933"],"unitdate_inclusive_ssm":["1715-1940"],"unitdate_bulk_ssim":["1871-1933"],"normalized_date_ssm":["1715/1940, bulk 1871/1933"],"normalized_title_ssm":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933"],"text":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933","Mss. 65 H88","/repositories/2/resources/8562","Autographs","Legal documents","United States--Lawyers","Autograph albums","Correspondence","240 items","Collection is open to all researchers. Manuscript collections and archival records may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations, such as the Virginia Public Records Act (Code of Virginia. § 42.1-76-91); and the Virginia Freedom of Information Act (Code of Virginia § 2.2-3705.5). Confidential material may include, but is not limited to, educational, medical, and personnel records. If sensitive material is found in this collection, please contact a staff member immediately. The disclosure of personally identifiable information pertaining to a living individual may have legal consequences for which the College of William and Mary assumes no responsibility.","Organization: This collection has been organized into 2 series: Series 1 includes Personal and Business Correspondence, and Series 2 includes an Autograph Collection. Arrangement: This collection is arranged into 2 series which are then broken down into subseries. Series 1 is arranged by date and Series 2 is arranged alphabetically.","Gift: 237 items, 1940.","Other Information:","Additional information may be found at http://ead.lib.virginia.edu/vivaead/published/wm/viw00087.frame","There are five collections within the Special Collections Research Center, Swem Library, College of William and Mary that relate to this collection. They include the John B. Floyd Papers, the Robert W. Hughes Papers, the Joseph E. Johnston Papers, the Preston Family Papers, and the Virginia Bar Examination Papers. The Library of Robert William Hughes is also available in the rare book section.","John B. Floyd Papers, Special Collections Research Center, Swem Library, College of William and Mary. John Buchanan Floyd Papers, 1831-1863, 1850- 1863. 72 items. Collection number: Mss. 65 F59","Robert W. Hughes, Special Collections Research Center, Swem Library, College of William and Mary. Robert W. Hughes Papers, 1818-1900. 103 items. Collection Number: Mss. 39.2 H87","Joseph E. Johnston Papers, Special Collections Research Center, Swem Library, College of William and Mary. Joseph E. Johnston Papers, 1825-1891. 264 items. Collection number: Mss. 39.1 J63","Preston Family Papers, Special Collections Research Center, Swem Library, College of William and Mary. Preston Family Papers, 1755-1836. 90 items. Collection Number: Mss. 39.1 P91","Virginia Bar Examination Papers, Special Collections Research Center, Swem Library, College of William and Mary. Virginia Bar Examination Papers, 1900- 1923. 1,306 items. Collection Number: Mss. 39.1 V81ba","The library belonging to Robert William Hughes is located at the Rare Books Department, Swem Library, College of William and Mary.","Another related collection is the Robert Morton Hughes Papers, located in Special Collections, Perry Library, Old Dominion University. This collection in significant because of the correspondence and other papers originally belonging to several of Hughes' relatives including Judge Robert W. Hughes, Governor John B. Floyd, and General Joseph E. Johnston. The collection also contains personal and political correspondence regarding Robert Morton Hughes' legal practice, involvement in Virginia politics, activities in support of education, longtime association with the College of William and Mary, and service on the State Board of Education and the Board of Directors of the Norfolk Public Library. The William and Mary collection of Robert Morton Hughes Papers compliments and does not duplicate the Robert Morton Hughes Papers at Old Dominion University.","Papers of Robert Morton Hughes, Special Collections, Perry Library, Old Dominion University, Norfolk, Virginia. Papers of Robert Morton Hughes, 1767- 1959.39 Hollinger Flat Boxes; 5 Hollinger Oversized Boxes and Additional Bound Volumes. Collection number: MG-7","Papers, 1871-1933, of Robert Morton Hughes of Norfolk, Virginia, concerning his law practice; his interest in maritime law; his biography of Joseph Eggleston Johnston; his influence in Virginia politics; and the College of William and Mary. Correspondents include Joseph Eggleston Johnston, Fitzhugh Lee, Sir Arthur Sullivan, Thomas Nelson Page, Woodrow Wilson, Flora (Cooke) Stuart and Theodore Roosevelt. There is also an autograph collection, 1715-1924, which includes signatures of Frances Hodgson Burnett, Mark Hanna, Oliver Wendell Holmes, Sr., Samuel L. Clemens and presidents of the United States.","Addition to Box 1, Folder 4","\"Genesis of the F.F.V.,\" a typed draft of a letter to the editor by Robert M. Hughes (with footnotes), \"Horse-Power in Historyquot; by Robert M. Hughes, a typed draft, a February 4, 1935 letter from Mae White (Mrs. William) Freeman to Robert M. Hughes thanking him for their visit to his library and a tax receipt for Charles C. Johnston of Abington, Virginia.","Before reproducing or quoting from any materials, in whole or in part, permission must be obtained from the Special Collections Research Center, and the holder of the copyright, if not Swem Library.","Special Collections Research Center","College of William and Mary--Alumni and alumnae","University of Virginia","Hughes, Robert Morton","Lincoln, Abraham, 1809-1865","English"],"collection_title_tesim":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933"],"collection_ssim":["Robert Morton Hughes Papers, 1715/1940, bulk 1871/1933"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["Mss. 65 H88","/repositories/2/resources/8562"],"unitid_tesim":["Mss. 65 H88","/repositories/2/resources/8562"],"repository_ssm":["College of William and Mary"],"repository_ssim":["College of William and Mary"],"creator_ssm":["Hughes, Robert Morton"],"creator_ssim":["Hughes, Robert Morton"],"creator_persname_ssim":["Hughes, Robert Morton","Lincoln, Abraham, 1809-1865"],"creator_corpname_ssim":["Special Collections Research Center","College of William and Mary--Alumni and alumnae","University of Virginia"],"creators_ssim":["Hughes, Robert Morton","Lincoln, Abraham, 1809-1865","Special Collections Research Center","College of William and Mary--Alumni and alumnae","University of Virginia"],"access_terms_ssm":["Before reproducing or quoting from any materials, in whole or in part, permission must be obtained from the Special Collections Research Center, and the holder of the copyright, if not Swem Library."],"access_subjects_ssim":["Autographs","Legal documents","United States--Lawyers","Autograph albums","Correspondence"],"access_subjects_ssm":["Autographs","Legal documents","United States--Lawyers","Autograph albums","Correspondence"],"has_online_content_ssim":["false"],"physdesc_tesim":["240 items"],"extent_ssm":["1.50 Linear Feet"],"extent_tesim":["1.50 Linear Feet"],"genreform_ssim":["Autograph albums","Correspondence"],"date_range_isim":[1715,1716,1717,1718,1719,1720,1721,1722,1723,1724,1725,1726,1727,1728,1729,1730,1731,1732,1733,1734,1735,1736,1737,1738,1739,1740,1741,1742,1743,1744,1745,1746,1747,1748,1749,1750,1751,1752,1753,1754,1755,1756,1757,1758,1759,1760,1761,1762,1763,1764,1765,1766,1767,1768,1769,1770,1771,1772,1773,1774,1775,1776,1777,1778,1779,1780,1781,1782,1783,1784,1785,1786,1787,1788,1789,1790,1791,1792,1793,1794,1795,1796,1797,1798,1799,1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940],"accessrestrict_html_tesm":["\u003cp\u003eCollection is open to all researchers. Manuscript collections and archival records may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations, such as the Virginia Public Records Act (Code of Virginia. § 42.1-76-91); and the Virginia Freedom of Information Act (Code of Virginia § 2.2-3705.5). Confidential material may include, but is not limited to, educational, medical, and personnel records. If sensitive material is found in this collection, please contact a staff member immediately. The disclosure of personally identifiable information pertaining to a living individual may have legal consequences for which the College of William and Mary assumes no responsibility.\u003c/p\u003e "],"accessrestrict_heading_ssm":["Conditions Governing Access:"],"accessrestrict_tesim":["Collection is open to all researchers. Manuscript collections and archival records may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations, such as the Virginia Public Records Act (Code of Virginia. § 42.1-76-91); and the Virginia Freedom of Information Act (Code of Virginia § 2.2-3705.5). Confidential material may include, but is not limited to, educational, medical, and personnel records. If sensitive material is found in this collection, please contact a staff member immediately. The disclosure of personally identifiable information pertaining to a living individual may have legal consequences for which the College of William and Mary assumes no responsibility."],"arrangement_html_tesm":["\u003cp\u003eOrganization: This collection has been organized into 2 series: Series 1 includes Personal and Business Correspondence, and Series 2 includes an Autograph Collection. Arrangement: This collection is arranged into 2 series which are then broken down into subseries. Series 1 is arranged by date and Series 2 is arranged alphabetically.\u003c/p\u003e "],"arrangement_heading_ssm":["Arrangement of Materials:"],"arrangement_tesim":["Organization: This collection has been organized into 2 series: Series 1 includes Personal and Business Correspondence, and Series 2 includes an Autograph Collection. Arrangement: This collection is arranged into 2 series which are then broken down into subseries. Series 1 is arranged by date and Series 2 is arranged alphabetically."],"bioghist_html_tesm":["\u003ca href=\"http://scrc.swem.wm.edu/wiki/index.php/Robert%20Morton%20Hughes\u0026amp;quot;\u0026gt;http://scrc.swem.wm.edu/wiki/index.php/Robert%20Morton%20Hughes\u0026amp;lt;/a\u0026amp;gt;.%20%20\u0026lt;/bioghist\u0026gt;%20%20%20\u0026lt;acqinfo%20id=\"\u003e\u003c/a\u003easpace_6ed40bada20fbae9b9913bc625eccaa4\"\u0026gt;\n ","\u003cp\u003eGift: 237 items, 1940.\u003c/p\u003e "],"bioghist_heading_ssm":["Biographical Information:"],"bioghist_tesim":["Gift: 237 items, 1940."],"odd_html_tesm":["\u003cp\u003eOther Information:\u003c/p\u003e","\u003cp\u003e Additional information may be found at http://ead.lib.virginia.edu/vivaead/published/wm/viw00087.frame\u003c/p\u003e "],"odd_heading_ssm":["General"],"odd_tesim":["Other Information:","Additional information may be found at http://ead.lib.virginia.edu/vivaead/published/wm/viw00087.frame"],"prefercite_html_tesm":["\u003cp\u003eRobert Morton Hughes Papers, Special Collections Research Center, Swem Library, College of William and Mary.\u003c/p\u003e "],"prefercite_tesim":["Robert Morton Hughes Papers, Special Collections Research Center, Swem Library, College of William and Mary."],"relatedmaterial_html_tesm":["\u003cp\u003eThere are five collections within the Special Collections Research Center, Swem Library, College of William and Mary that relate to this collection. They include the John B. Floyd Papers, the Robert W. Hughes Papers, the Joseph E. Johnston Papers, the Preston Family Papers, and the Virginia Bar Examination Papers. The Library of Robert William Hughes is also available in the rare book section.\u003c/p\u003e","\u003cp\u003e John B. Floyd Papers, Special Collections Research Center, Swem Library, College of William and Mary. John Buchanan Floyd Papers, 1831-1863, 1850- 1863. 72 items. Collection number: Mss. 65 F59\u003c/p\u003e","\u003cp\u003e Robert W. Hughes, Special Collections Research Center, Swem Library, College of William and Mary. Robert W. Hughes Papers, 1818-1900. 103 items. Collection Number: Mss. 39.2 H87\u003c/p\u003e","\u003cp\u003e Joseph E. Johnston Papers, Special Collections Research Center, Swem Library, College of William and Mary. Joseph E. Johnston Papers, 1825-1891. 264 items. Collection number: Mss. 39.1 J63\u003c/p\u003e","\u003cp\u003e Preston Family Papers, Special Collections Research Center, Swem Library, College of William and Mary. Preston Family Papers, 1755-1836. 90 items. Collection Number: Mss. 39.1 P91\u003c/p\u003e","\u003cp\u003e Virginia Bar Examination Papers, Special Collections Research Center, Swem Library, College of William and Mary. Virginia Bar Examination Papers, 1900- 1923. 1,306 items. Collection Number: Mss. 39.1 V81ba\u003c/p\u003e","\u003cp\u003e The library belonging to Robert William Hughes is located at the Rare Books Department, Swem Library, College of William and Mary.\u003c/p\u003e","\u003cp\u003e Another related collection is the Robert Morton Hughes Papers, located in Special Collections, Perry Library, Old Dominion University. This collection in significant because of the correspondence and other papers originally belonging to several of Hughes' relatives including Judge Robert W. Hughes, Governor John B. Floyd, and General Joseph E. Johnston. The collection also contains personal and political correspondence regarding Robert Morton Hughes' legal practice, involvement in Virginia politics, activities in support of education, longtime association with the College of William and Mary, and service on the State Board of Education and the Board of Directors of the Norfolk Public Library. The William and Mary collection of Robert Morton Hughes Papers compliments and does not duplicate the Robert Morton Hughes Papers at Old Dominion University.\u003c/p\u003e","\u003cp\u003e Papers of Robert Morton Hughes, Special Collections, Perry Library, Old Dominion University, Norfolk, Virginia. Papers of Robert Morton Hughes, 1767- 1959.39 Hollinger Flat Boxes; 5 Hollinger Oversized Boxes and Additional Bound Volumes. Collection number: MG-7\u003c/p\u003e "],"relatedmaterial_heading_ssm":["Related Materials:"],"relatedmaterial_tesim":["There are five collections within the Special Collections Research Center, Swem Library, College of William and Mary that relate to this collection. They include the John B. Floyd Papers, the Robert W. Hughes Papers, the Joseph E. Johnston Papers, the Preston Family Papers, and the Virginia Bar Examination Papers. The Library of Robert William Hughes is also available in the rare book section.","John B. Floyd Papers, Special Collections Research Center, Swem Library, College of William and Mary. John Buchanan Floyd Papers, 1831-1863, 1850- 1863. 72 items. Collection number: Mss. 65 F59","Robert W. Hughes, Special Collections Research Center, Swem Library, College of William and Mary. Robert W. Hughes Papers, 1818-1900. 103 items. Collection Number: Mss. 39.2 H87","Joseph E. Johnston Papers, Special Collections Research Center, Swem Library, College of William and Mary. Joseph E. Johnston Papers, 1825-1891. 264 items. Collection number: Mss. 39.1 J63","Preston Family Papers, Special Collections Research Center, Swem Library, College of William and Mary. Preston Family Papers, 1755-1836. 90 items. Collection Number: Mss. 39.1 P91","Virginia Bar Examination Papers, Special Collections Research Center, Swem Library, College of William and Mary. Virginia Bar Examination Papers, 1900- 1923. 1,306 items. Collection Number: Mss. 39.1 V81ba","The library belonging to Robert William Hughes is located at the Rare Books Department, Swem Library, College of William and Mary.","Another related collection is the Robert Morton Hughes Papers, located in Special Collections, Perry Library, Old Dominion University. This collection in significant because of the correspondence and other papers originally belonging to several of Hughes' relatives including Judge Robert W. Hughes, Governor John B. Floyd, and General Joseph E. Johnston. The collection also contains personal and political correspondence regarding Robert Morton Hughes' legal practice, involvement in Virginia politics, activities in support of education, longtime association with the College of William and Mary, and service on the State Board of Education and the Board of Directors of the Norfolk Public Library. The William and Mary collection of Robert Morton Hughes Papers compliments and does not duplicate the Robert Morton Hughes Papers at Old Dominion University.","Papers of Robert Morton Hughes, Special Collections, Perry Library, Old Dominion University, Norfolk, Virginia. Papers of Robert Morton Hughes, 1767- 1959.39 Hollinger Flat Boxes; 5 Hollinger Oversized Boxes and Additional Bound Volumes. Collection number: MG-7"],"scopecontent_html_tesm":["\u003cp\u003ePapers, 1871-1933, of Robert Morton Hughes of Norfolk, Virginia, concerning his law practice; his interest in maritime law; his biography of Joseph Eggleston Johnston; his influence in Virginia politics; and the College of William and Mary. Correspondents include Joseph Eggleston Johnston, Fitzhugh Lee, Sir Arthur Sullivan, Thomas Nelson Page, Woodrow Wilson, Flora (Cooke) Stuart and Theodore Roosevelt. There is also an autograph collection, 1715-1924, which includes signatures of Frances Hodgson Burnett, Mark Hanna, Oliver Wendell Holmes, Sr., Samuel L. Clemens and presidents of the United States.\u003c/p\u003e","\u003cp\u003e  \u003c/p\u003e","\u003cp\u003e Addition to Box 1, Folder 4\u003c/p\u003e","\u003cp\u003e \"Genesis of the F.F.V.,\" a typed draft of a letter to the editor by Robert M. Hughes (with footnotes), \"Horse-Power in Historyquot; by Robert M. Hughes, a typed draft, a February 4, 1935 letter from Mae White (Mrs. William) Freeman to Robert M. Hughes thanking him for their visit to his library and a tax receipt for Charles C. Johnston of Abington, Virginia.\u003c/p\u003e "],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Papers, 1871-1933, of Robert Morton Hughes of Norfolk, Virginia, concerning his law practice; his interest in maritime law; his biography of Joseph Eggleston Johnston; his influence in Virginia politics; and the College of William and Mary. Correspondents include Joseph Eggleston Johnston, Fitzhugh Lee, Sir Arthur Sullivan, Thomas Nelson Page, Woodrow Wilson, Flora (Cooke) Stuart and Theodore Roosevelt. There is also an autograph collection, 1715-1924, which includes signatures of Frances Hodgson Burnett, Mark Hanna, Oliver Wendell Holmes, Sr., Samuel L. Clemens and presidents of the United States.","Addition to Box 1, Folder 4","\"Genesis of the F.F.V.,\" a typed draft of a letter to the editor by Robert M. Hughes (with footnotes), \"Horse-Power in Historyquot; by Robert M. Hughes, a typed draft, a February 4, 1935 letter from Mae White (Mrs. William) Freeman to Robert M. Hughes thanking him for their visit to his library and a tax receipt for Charles C. Johnston of Abington, Virginia."],"userestrict_html_tesm":["\u003cp\u003eBefore reproducing or quoting from any materials, in whole or in part, permission must be obtained from the Special Collections Research Center, and the holder of the copyright, if not Swem Library.\u003c/p\u003e "],"userestrict_heading_ssm":["Conditions Governing Use:"],"userestrict_tesim":["Before reproducing or quoting from any materials, in whole or in part, permission must be obtained from the Special Collections Research Center, and the holder of the copyright, if not Swem Library."],"corpname_ssim":["Special Collections Research Center","College of William and Mary--Alumni and alumnae","University of Virginia"],"names_coll_ssim":["College of William and Mary--Alumni and alumnae","University of Virginia","Lincoln, Abraham, 1809-1865"],"persname_ssim":["Hughes, Robert Morton","Lincoln, Abraham, 1809-1865"],"names_ssim":["Special Collections Research Center","College of William and Mary--Alumni and alumnae","University of Virginia","Hughes, Robert Morton","Lincoln, Abraham, 1809-1865"],"language_ssim":["English"],"total_component_count_is":203,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T23:04:15.155Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://search.arvasarchive.org/catalog/viw_repositories_2_resources_8562_c01_c03_c08"}},{"id":"viu_viu00086_c07_c07","type":"Item","attributes":{"title":"\"The \n Potters' Log, \" kept by \n Vine Colby, Scribe for the\n group, from October 13, 1905 to October 14, 1906. The\n Log contains the records entered by Vine and pencil\n sketches by \n Caroline Risque. Also included\n is an \"Index to the Tricks, Manners and Opinions of\n the \n Potters. \", 1905/1906","breadcrumbs":{"id":"https://search.arvasarchive.org/catalog/viu_viu00086_c07_c07#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_viu00086_c07_c07","ref_ssm":["viu_viu00086_c07_c07"],"id":"viu_viu00086_c07_c07","ead_ssi":"viu_viu00086","_root_":"viu_viu00086","_nest_parent_":"viu_viu00086_c07","parent_ssi":"viu_viu00086_c07","parent_ssim":["Sara Teasdale Collection \n 1888-1934","OVERSIZE"],"parent_ids_ssim":["viu_viu00086","viu_viu00086_c07"],"title_filing_ssi":"\"The \n Potters' Log,\" kept by \n Vine Colby, Scribe for the\n group, from October 13, 1905 to October 14, 1906. The\n Log contains the records entered by Vine and pencil\n sketches by \n Caroline Risque. Also included\n is an \"Index to the Tricks, Manners and Opinions of\n the \n Potters. \"","title_ssm":["\"The \n Potters' Log, \" kept by \n Vine Colby, Scribe for the\n group, from October 13, 1905 to October 14, 1906. The\n Log contains the records entered by Vine and pencil\n sketches by \n Caroline Risque. Also included\n is an \"Index to the Tricks, Manners and Opinions of\n the \n Potters. \""],"title_tesim":["\"The \n Potters' Log, \" kept by \n Vine Colby, Scribe for the\n group, from October 13, 1905 to October 14, 1906. The\n Log contains the records entered by Vine and pencil\n sketches by \n Caroline Risque. Also included\n is an \"Index to the Tricks, Manners and Opinions of\n the \n Potters. \""],"normalized_title_ssm":["\"The \n Potters' Log, \" kept by \n Vine Colby, Scribe for the\n group, from October 13, 1905 to October 14, 1906. The\n Log contains the records entered by Vine and pencil\n sketches by \n Caroline Risque. Also included\n is an \"Index to the Tricks, Manners and Opinions of\n the \n Potters. \", 1905/1906"],"text":["\"The \n Potters' Log, \" kept by \n Vine Colby, Scribe for the\n group, from October 13, 1905 to October 14, 1906. The\n Log contains the records entered by Vine and pencil\n sketches by \n Caroline Risque. Also included\n is an \"Index to the Tricks, Manners and Opinions of\n the \n Potters. \", 1905/1906","Sara Teasdale Collection \n 1888-1934","OVERSIZE","Box Slipcase II","Potters","Vine Colby","Caroline Risque"],"parent_unittitles_ssm":["Sara Teasdale Collection \n 1888-1934","OVERSIZE"],"parent_unittitles_tesim":["Sara Teasdale Collection \n 1888-1934","OVERSIZE"],"normalized_date_ssm":["1905/1906"],"unitdate_other_ssim":["1905-1906"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[2],"sort_isi":733,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Sara Teasdale Collection \n 1888-1934"],"containers_ssim":["Box Slipcase II"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["Collection is open to research"],"parent_access_terms_tesm":["See the \n \n University of Virginia Library’s use policy."],"corpname_ssim":["Potters"],"persname_ssim":["Vine Colby","Caroline Risque"],"names_ssim":["Potters","Vine Colby","Caroline Risque"],"date_range_isim":[1905,1906],"_nest_path_":"/components#6/components#6","timestamp":"2026-08-14T22:55:22.701Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_viu00086","ead_ssi":"viu_viu00086","_root_":"viu_viu00086","_nest_parent_":"viu_viu00086","ead_source_url_ssi":"data/uva-sc/viu00086.xml","title_ssm":["Sara Teasdale Collection \n 1888-1934"],"title_tesim":["Sara Teasdale Collection \n 1888-1934"],"normalized_title_ssm":["Sara Teasdale Collection \n 1888-1934"],"text":["Sara Teasdale Collection \n 1888-1934","8170-d","ca. 700 items","Collection is open to research","Funded in part by a grant from the National Endowment\n for the Humanities","See the \n \n University of Virginia Library’s use policy.","University of Virginia. Library. Special\n Collections Dept.","Potters","Charles Scribner's Sons","Harper \u0026 Brothers","Small, Maynard \u0026 Company","Hosmer Hall","The Century Company","G. P. Putnam's Sons","G.P. Putnam's Sons","Poetry Society of America","Chappell \u0026 Co., Ltd.","Putnam Publishing\n Company","Monday Club","The Denver Music Company","The MacMillan Company","G. Schirmer (Inc.)","Stix, Baer, \u0026 Fuller","MacMillan","Underwood's News Photo Service","The Centennial Club","Poets Corner","Browning Society","MacMillan Company","Belgian Scholarship\n Committee","Houghton Mifflin Company","Charles Scribner \u0026\n Sons","Dodd, Mead, \u0026 Company","Writers Guild","University of Missouri","National League","American Ambulance Fund","Kilmarnock, Scotland","Greek Ethics Club","State Historical Society of\n Missouri","St. Louis Museum of Fine\n Arts","National Arts Club","Poetry Society of\n America","J. B. Lippincott Company","Frank A. Munsey","Philip Roeder Book and Stationery\n Company","Vine Colby","Lawrence Hanley","Celia Ellen\n Harris","Margaret Scott\n Lawler","Nadaud","Paul Janis","Vine Colby\n McCasland","Williamina\n Parrish","Sara Teasdale","Frances S.\n Porcher","Christina Rossetti","Barbara George","Patience Worth","William Marion Reedy","Marion Cummings Stanley","Caroline Risque","Jennie M.A. Jones","Susan Creighton Williams","(Williamina Parrish","[Sara Teasdale]","[Vine Colby]","George W. Teasdale","E[leanora] D[use]","Williamina Parrish","Lillie Rose Ernst","Thomas B. Mosher","Elizabeth M. Brown","Caroline White McKinney","Will J. Thornton","Fred R. Macauley","Olga Nethersole","Frances S. Porcher","Celia Ellen Harris","Mary D. Harris","Arthur Symons","Lee B. Hildebrand","Julia Marlowe","Louise McNair","J.P. Greene","Marie Isabel Miller","Mary C. Burke","Guiseppe Masi","Jerome A. Quay","Eleanora Duse","Paul Y. Tupper","Joseph B. Gilder","Laura A. Proetz","Sidney Rogers Cook","M. Augusta Bailey","Dorothy Colby","Arthur Hornblow","Inez (Dutro) George","Frank George","Frances Joseph","Mary F. Raphael","Sara Teasdale,","Pinkie D. McGrew","Agnes M. Schulenberg","John Myers O'Hara","Sappho","Oliver H. Campbell","Adelia C. Arens","H. Nelson Gay","John Keats","Elizabeth Waddell","R.E. Lee Gibson","William H. Hills","Elizabeth McCracken","Mary Elizabeth Willard Teasdale","Bruce M. Stanley","Thekla Bernays","Sidney Fane","Algernon Charles Swinburne","Alice Evelyn Watson","Orrick S. Johns","Ethel M. Kelly","Thomas C. Clark","Witter Bynner","John Stapleton Cowley","Zoe Aikin","Mamie Teasdale Wheless","[John Myers O'Hara]","Alexander N. DeMenil","Madison Cawein","Clayton Hamilton","Chen E. Cory","Alfred Edward Housman","Frances M. Weir","Leopold Godowsky","Olive Ruby Hammon","Jessie Johnston Linton","Joan A. Rae","George Sterling","B. Russell Herts","Louis Untermeyer","Mitchell Kennerley","Michael Monahan","Richard Le Galliene","Robert Underwood Johnson","Albert Victor Young","Petronelle Sombart","Charles Hanson Towne","George Sylvester Viereck","Joseph Benson Gilder","Jessie Belle Rittenhouse","Henry Mills Alden","Ernest R. Kroeger","John Shea","Natalie Bigelow","H. Alexander Matthews","Lily S. Anthony","Orrick Johns","Willa Sibert Cather","Homer Croy","A.D. Kerry","William H. Gardner","S.T. Newton","Henry Van Dyke","Curtis Hidden Page","Frederick Oakes Sylvester","Elizabeth Barrett Browning","John L. Hervey","F. Dewey Richards","Julia Marlowe Sothern","Julia G. Scott","Frank K. Hallack","Edward L. Preetorius","Louis H. Behrens","Theodosia Garrison","Richard LeGallienne","Paul E. More","Charles E. Savage","John Sanburn Phillips","Edith M. Thomas","Elizabeth K. Mew","Rufus Rockwell Wilson","Cale Young Rice","Josephine Peabody","Percy Mackaye","Rudyard Kipling","Fannie L. Richey","George S. Johns","Ella M. 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